Cargando…
Subchronic Oral Toxicity Study of Genetically Modified Rice Rich in β-Carotene in Wistar Rats
(1) Background: a hybrid black rice rich in β-carotene carrying the psy and crtI genes (HJM) was evaluated in Wistar rats by a 90-day feeding study, aiming to assess its dietary safety. (2) Methods: the HJM rice and its parental line HS were included in rats’ diets at levels of 73.5% and 75.5%, resp...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196761/ https://www.ncbi.nlm.nih.gov/pubmed/34064012 http://dx.doi.org/10.3390/ijerph18115526 |
_version_ | 1783706761171042304 |
---|---|
author | Xia, Ying Zuo, Shanshan Zheng, Yanhua Liu, Jin Yang, Wenxiang Tang, Xiaoqiao Ke, Xianghong Zhuo, Qin Yang, Xiaoguang Li, Yang Fan, Bolin |
author_facet | Xia, Ying Zuo, Shanshan Zheng, Yanhua Liu, Jin Yang, Wenxiang Tang, Xiaoqiao Ke, Xianghong Zhuo, Qin Yang, Xiaoguang Li, Yang Fan, Bolin |
author_sort | Xia, Ying |
collection | PubMed |
description | (1) Background: a hybrid black rice rich in β-carotene carrying the psy and crtI genes (HJM) was evaluated in Wistar rats by a 90-day feeding study, aiming to assess its dietary safety. (2) Methods: the HJM rice and its parental line HS were included in rats’ diets at levels of 73.5% and 75.5%, respectively. The AIN-93 diet was administered as a nutritional control. No adverse effects on animal behavior or weight gain were observed during the study. Blood samples were collected and analyzed, and standard hematological and biochemical parameters were compared. (3) Results: Some parameters were found to be significantly different, though they remained within the normal range for rats of this breed and age. In addition, upon sacrifice, various organs were weighed, and macroscopic and histopathological examinations were performed, with only minor changes to report. (4) Conclusions: HJM rice exhibited no adverse or toxic effects in Wistar rats in this 90-day study. |
format | Online Article Text |
id | pubmed-8196761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81967612021-06-13 Subchronic Oral Toxicity Study of Genetically Modified Rice Rich in β-Carotene in Wistar Rats Xia, Ying Zuo, Shanshan Zheng, Yanhua Liu, Jin Yang, Wenxiang Tang, Xiaoqiao Ke, Xianghong Zhuo, Qin Yang, Xiaoguang Li, Yang Fan, Bolin Int J Environ Res Public Health Article (1) Background: a hybrid black rice rich in β-carotene carrying the psy and crtI genes (HJM) was evaluated in Wistar rats by a 90-day feeding study, aiming to assess its dietary safety. (2) Methods: the HJM rice and its parental line HS were included in rats’ diets at levels of 73.5% and 75.5%, respectively. The AIN-93 diet was administered as a nutritional control. No adverse effects on animal behavior or weight gain were observed during the study. Blood samples were collected and analyzed, and standard hematological and biochemical parameters were compared. (3) Results: Some parameters were found to be significantly different, though they remained within the normal range for rats of this breed and age. In addition, upon sacrifice, various organs were weighed, and macroscopic and histopathological examinations were performed, with only minor changes to report. (4) Conclusions: HJM rice exhibited no adverse or toxic effects in Wistar rats in this 90-day study. MDPI 2021-05-21 /pmc/articles/PMC8196761/ /pubmed/34064012 http://dx.doi.org/10.3390/ijerph18115526 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Xia, Ying Zuo, Shanshan Zheng, Yanhua Liu, Jin Yang, Wenxiang Tang, Xiaoqiao Ke, Xianghong Zhuo, Qin Yang, Xiaoguang Li, Yang Fan, Bolin Subchronic Oral Toxicity Study of Genetically Modified Rice Rich in β-Carotene in Wistar Rats |
title | Subchronic Oral Toxicity Study of Genetically Modified Rice Rich in β-Carotene in Wistar Rats |
title_full | Subchronic Oral Toxicity Study of Genetically Modified Rice Rich in β-Carotene in Wistar Rats |
title_fullStr | Subchronic Oral Toxicity Study of Genetically Modified Rice Rich in β-Carotene in Wistar Rats |
title_full_unstemmed | Subchronic Oral Toxicity Study of Genetically Modified Rice Rich in β-Carotene in Wistar Rats |
title_short | Subchronic Oral Toxicity Study of Genetically Modified Rice Rich in β-Carotene in Wistar Rats |
title_sort | subchronic oral toxicity study of genetically modified rice rich in β-carotene in wistar rats |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196761/ https://www.ncbi.nlm.nih.gov/pubmed/34064012 http://dx.doi.org/10.3390/ijerph18115526 |
work_keys_str_mv | AT xiaying subchronicoraltoxicitystudyofgeneticallymodifiedricerichinbcaroteneinwistarrats AT zuoshanshan subchronicoraltoxicitystudyofgeneticallymodifiedricerichinbcaroteneinwistarrats AT zhengyanhua subchronicoraltoxicitystudyofgeneticallymodifiedricerichinbcaroteneinwistarrats AT liujin subchronicoraltoxicitystudyofgeneticallymodifiedricerichinbcaroteneinwistarrats AT yangwenxiang subchronicoraltoxicitystudyofgeneticallymodifiedricerichinbcaroteneinwistarrats AT tangxiaoqiao subchronicoraltoxicitystudyofgeneticallymodifiedricerichinbcaroteneinwistarrats AT kexianghong subchronicoraltoxicitystudyofgeneticallymodifiedricerichinbcaroteneinwistarrats AT zhuoqin subchronicoraltoxicitystudyofgeneticallymodifiedricerichinbcaroteneinwistarrats AT yangxiaoguang subchronicoraltoxicitystudyofgeneticallymodifiedricerichinbcaroteneinwistarrats AT liyang subchronicoraltoxicitystudyofgeneticallymodifiedricerichinbcaroteneinwistarrats AT fanbolin subchronicoraltoxicitystudyofgeneticallymodifiedricerichinbcaroteneinwistarrats |