Cyclodextrin Monomers and Polymers for Drug Activity Enhancement

Cyclodextrins (CDs) and cyclodextrin (CD)-based polymers are well-known complexing agents. One of their distinctive features is to increase the quantity of a drug in a solution or improve its delivery. However, in certain instances, the activity of the solutions is increased not only due to the incr...

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Autores principales: Matencio, Adrián, Hoti, Gjylije, Monfared, Yousef Khazaei, Rezayat, Azam, Pedrazzo, Alberto Rubin, Caldera, Fabrizio, Trotta, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196804/
https://www.ncbi.nlm.nih.gov/pubmed/34064190
http://dx.doi.org/10.3390/polym13111684
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author Matencio, Adrián
Hoti, Gjylije
Monfared, Yousef Khazaei
Rezayat, Azam
Pedrazzo, Alberto Rubin
Caldera, Fabrizio
Trotta, Francesco
author_facet Matencio, Adrián
Hoti, Gjylije
Monfared, Yousef Khazaei
Rezayat, Azam
Pedrazzo, Alberto Rubin
Caldera, Fabrizio
Trotta, Francesco
author_sort Matencio, Adrián
collection PubMed
description Cyclodextrins (CDs) and cyclodextrin (CD)-based polymers are well-known complexing agents. One of their distinctive features is to increase the quantity of a drug in a solution or improve its delivery. However, in certain instances, the activity of the solutions is increased not only due to the increase of the drug dose but also due to the drug complexation. Based on numerous studies reviewed, the drug appeared more active in a complex form. This review aims to summarize the performance of CDs and CD-based polymers as activity enhancers. Accordingly, the review is divided into two parts, i.e., the effect of CDs as active drugs and as enhancers in antimicrobials, antivirals, cardiovascular diseases, cancer, neuroprotective agents, and antioxidants.
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spelling pubmed-81968042021-06-13 Cyclodextrin Monomers and Polymers for Drug Activity Enhancement Matencio, Adrián Hoti, Gjylije Monfared, Yousef Khazaei Rezayat, Azam Pedrazzo, Alberto Rubin Caldera, Fabrizio Trotta, Francesco Polymers (Basel) Review Cyclodextrins (CDs) and cyclodextrin (CD)-based polymers are well-known complexing agents. One of their distinctive features is to increase the quantity of a drug in a solution or improve its delivery. However, in certain instances, the activity of the solutions is increased not only due to the increase of the drug dose but also due to the drug complexation. Based on numerous studies reviewed, the drug appeared more active in a complex form. This review aims to summarize the performance of CDs and CD-based polymers as activity enhancers. Accordingly, the review is divided into two parts, i.e., the effect of CDs as active drugs and as enhancers in antimicrobials, antivirals, cardiovascular diseases, cancer, neuroprotective agents, and antioxidants. MDPI 2021-05-21 /pmc/articles/PMC8196804/ /pubmed/34064190 http://dx.doi.org/10.3390/polym13111684 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Matencio, Adrián
Hoti, Gjylije
Monfared, Yousef Khazaei
Rezayat, Azam
Pedrazzo, Alberto Rubin
Caldera, Fabrizio
Trotta, Francesco
Cyclodextrin Monomers and Polymers for Drug Activity Enhancement
title Cyclodextrin Monomers and Polymers for Drug Activity Enhancement
title_full Cyclodextrin Monomers and Polymers for Drug Activity Enhancement
title_fullStr Cyclodextrin Monomers and Polymers for Drug Activity Enhancement
title_full_unstemmed Cyclodextrin Monomers and Polymers for Drug Activity Enhancement
title_short Cyclodextrin Monomers and Polymers for Drug Activity Enhancement
title_sort cyclodextrin monomers and polymers for drug activity enhancement
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196804/
https://www.ncbi.nlm.nih.gov/pubmed/34064190
http://dx.doi.org/10.3390/polym13111684
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