Cargando…

CSF1/CSF1R Axis Blockade Limits Mesothelioma and Enhances Efficiency of Anti-PDL1 Immunotherapy

SIMPLE SUMMARY: CSF1/CSF1R signaling mediates tumor-associated macrophages recruitment and M2 polarization. M2 TAMs are dominant immune populations infiltrating mesothelioma tumors. We evaluated the role of CSF1/CSF1R axis blockade in tumor-infiltrating immune subsets. We also examined the effect of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Magkouta, Sophia Fotiou, Vaitsi, Photene Christou, Pappas, Apostolos Georgiou, Iliopoulou, Marianthi, Kosti, Chrysavgi Nikolaou, Psarra, Katherina, Kalomenidis, Ioannis Theodorou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196870/ https://www.ncbi.nlm.nih.gov/pubmed/34067348 http://dx.doi.org/10.3390/cancers13112546

Ejemplares similares

CSF1/CSF1R signaling mediates malignant pleural effusion formation
por: Kosti, Chrysavgi N., et al.
Publicado: (2022)

MTH1 Inhibition Alleviates Immune Suppression and Enhances the Efficacy of Anti-PD-L1 Immunotherapy in Experimental Mesothelioma
por: Magkouta, Sophia F., et al.
Publicado: (2023)

Icmt inhibition exerts anti-angiogenic and anti-hyperpermeability activities impeding malignant pleural effusion
por: Magkouta, Sophia, et al.
Publicado: (2016)

Involvement of the M-CSF/IL-34/CSF-1R pathway in malignant pleural mesothelioma
por: Blondy, Thibaut, et al.
Publicado: (2020)

Targeting Tie-2/angiopoietin axis in experimental mesothelioma confers differential responses and raises predictive implications
por: Magkouta, Sophia, et al.
Publicado: (2018)

Autocrine CSF-1R signaling drives mesothelioma chemoresistance via AKT activation
por: Cioce, M, et al.
Publicado: (2014)

Association between CSF1 and CSF1R Polymorphisms and Parkinson’s Disease in Taiwan
por: Chang, Kuo-Hsuan, et al.
Publicado: (2019)

S-nitrosylation of CSF1 receptor increases the efficacy of CSF1R blockage against prostate cancer
por: Firdaus, Fakiha, et al.
Publicado: (2022)

Cloning and expression of porcine Colony Stimulating Factor-1 (CSF-1) and Colony Stimulating Factor-1 Receptor (CSF-1R) and analysis of the species specificity of stimulation by CSF-1 and Interleukin 34
por: Gow, Deborah J., et al.
Publicado: (2012)

Value of CSF-Cl, CSF-GS, CSF-MALB, and CSF-ADA in Differential Diagnosis of Secondary Hydrocephalus
por: Huang, Junzhang, et al.
Publicado: (2022)

Retracted: Value of CSF-Cl, CSF-GS, CSF-MALB, and CSF-ADA in Differential Diagnosis of Secondary Hydrocephalus
por: Imaging, Contrast Media & Molecular
Publicado: (2023)

Herpes zoster in HIV-1 infection: The role of CSF pleocytosis in secondary CSF escape and discordance
por: Hagberg, Lars, et al.
Publicado: (2020)

Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival
por: Cheng, Baoying, et al.
Publicado: (2021)

Implication of microglia activation and CSF1/CSF1R pathway in lumbar disc degeneration-related back pain
por: Yang, Ge, et al.
Publicado: (2018)

Two Novel Intronic Mutations in the CSF1R Gene in Two Families With CSF1R-Microglial Encephalopathy
por: Jiang, Jiwei, et al.
Publicado: (2022)

CSF/plasma HIV-1 RNA discordance even at low levels is associated with up-regulation of host inflammatory mediators in CSF()
por: Nightingale, Sam, et al.
Publicado: (2016)

G-CSF and GM-CSF in clinical trials.
por: Antman, K. H.
Publicado: (1990)

Regulation of MHC class II gene expression in macrophages by hematopoietic colony-stimulating factors (CSF). Induction by granulocyte/macrophage CSF and inhibition by CSF-1
Publicado: (1989)

Evidence that blood–CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogen
por: Cowan, Robert P., et al.
Publicado: (2021)

Regulation of the MAD1 promoter by G-CSF
por: Jiang, Kan, et al.
Publicado: (2008)

Macrophage Migration and Its Regulation by CSF-1
por: Pixley, Fiona J.
Publicado: (2012)

CSF-1/CSF-1R axis is associated with epithelial/mesenchymal hybrid phenotype in epithelial-like inflammatory breast cancer
por: Kai, Kazuharu, et al.
Publicado: (2018)

Deletion of a Csf1r enhancer selectively impacts CSF1R expression and development of tissue macrophage populations
por: Rojo, Rocío, et al.
Publicado: (2019)

CSF1/CSF1R-mediated Crosstalk Between Choroidal Vascular Endothelial Cells and Macrophages Promotes Choroidal Neovascularization
por: Zhou, Yamei, et al.
Publicado: (2021)

Kinetics of Immune Subsets in COVID-19 Patients Treated with Corticosteroids
por: Pappas, Apostolos Georgios, et al.
Publicado: (2022)

P53-regulated miR-320a targets PDL1 and is downregulated in malignant mesothelioma
por: Costa, Caterina, et al.
Publicado: (2020)

IL-1 production as a regulator of G-CSF and IL-6 production in CSF-producing cell lines.
por: Suzuki, A., et al.
Publicado: (1992)

Rabbit M1 and M2 macrophages can be induced by human recombinant GM‐CSF and M‐CSF
por: Yamane, Kazuyoshi, et al.
Publicado: (2016)

Withholding of M-CSF Supplement Reprograms Macrophages to M2-Like via Endogenous CSF-1 Activation
por: Chen, Yu-Chih, et al.
Publicado: (2021)

CSF1R Inhibition Combined with GM-CSF Reprograms Macrophages and Disrupts Protumoral Interplays with AML Cells
por: Smirnova, Tatiana, et al.
Publicado: (2021)

In-depth Characterization of the Cerebrospinal Fluid (CSF) Proteome Displayed Through the CSF Proteome Resource (CSF-PR)
por: Guldbrandsen, Astrid, et al.
Publicado: (2014)

CSF Presenilin-1 complexes are increased in Alzheimer’s disease
por: García-Ayllón, María-Salud, et al.
Publicado: (2013)

Neuropsychological profile of CSF1R-related leukoencephalopathy
por: Rush, Beth K., et al.
Publicado: (2023)

Increased expression of CSF1 in patients with eosinophilic asthma
por: Du, Lijuan, et al.
Publicado: (2023)

Correction: P53-regulated miR-320a targets PDL1 and is downregulated in malignant mesothelioma
por: Costa, Caterina, et al.
Publicado: (2020)

A role for G-CSF and GM-CSF in nonmyeloid cancers
por: Aliper, Alexander M, et al.
Publicado: (2014)

CSF protein variations correlates with CSF oscillations in hydrocephalus patients
por: Balédent, Olivier, et al.
Publicado: (2015)

Identification of PDL1-Related Biomarkers to Select Lung Adenocarcinoma Patients for PD1/PDL1 Inhibitors
por: Wu, Yanping, et al.
Publicado: (2020)

Genetic and Pharmacological Targeting of CSF-1/CSF-1R Inhibits Tumor-Associated Macrophages and Impairs BRAF-Induced Thyroid Cancer Progression
por: Ryder, Mabel, et al.
Publicado: (2013)

Novel CSF1-S100A10 fusion gene and CSF1 transcript identified by RNA sequencing in tenosynovial giant cell tumors
por: PANAGOPOULOS, IOANNIS, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ac2jkdf0hpigliqk5cnf94pksf