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Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells
Leukemia is persistently a significant cause of illness and mortality worldwide. Urolithins, metabolites of ellagic acid and ellagitannins produced by gut microbiota, showed better bioactive compounds liable for the health benefits exerted by ellagic acid and ellagitannins containing pomegranate and...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196872/ https://www.ncbi.nlm.nih.gov/pubmed/34067305 http://dx.doi.org/10.3390/ijms22115465 |
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author | Alzahrani, Abdulaziz Musa Shait Mohammed, Mohammed Razeeth Alghamdi, Raed Ahmed Ahmad, Abrar Zamzami, Mazin A. Choudhry, Hani Khan, Mohammad Imran |
author_facet | Alzahrani, Abdulaziz Musa Shait Mohammed, Mohammed Razeeth Alghamdi, Raed Ahmed Ahmad, Abrar Zamzami, Mazin A. Choudhry, Hani Khan, Mohammad Imran |
author_sort | Alzahrani, Abdulaziz Musa |
collection | PubMed |
description | Leukemia is persistently a significant cause of illness and mortality worldwide. Urolithins, metabolites of ellagic acid and ellagitannins produced by gut microbiota, showed better bioactive compounds liable for the health benefits exerted by ellagic acid and ellagitannins containing pomegranate and walnuts. Here, we assessed the potential antileukemic activities of both urolithin A and urolithin B. Results showed that both urolithin A and B significantly inhibited the proliferation of leukemic cell lines Jurkat and K562, among which urolithin A showed the more prominent antiproliferative capability. Further, urolithin treatment alters leukemic cell metabolism, as evidenced by increased metabolic rate and notable changes in glutamine metabolism, one-carbon metabolism, and lipid metabolism. Next, we evidenced that both urolithins equally promoted apoptosis in leukemic cell lines. Based on these observations, we concluded that both urolithin A and B alter leukemic cell metabolome, resulting in a halt of proliferation, followed by apoptosis. The data can be used for designing new combinational therapies to eradicate leukemic cells. |
format | Online Article Text |
id | pubmed-8196872 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81968722021-06-13 Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells Alzahrani, Abdulaziz Musa Shait Mohammed, Mohammed Razeeth Alghamdi, Raed Ahmed Ahmad, Abrar Zamzami, Mazin A. Choudhry, Hani Khan, Mohammad Imran Int J Mol Sci Article Leukemia is persistently a significant cause of illness and mortality worldwide. Urolithins, metabolites of ellagic acid and ellagitannins produced by gut microbiota, showed better bioactive compounds liable for the health benefits exerted by ellagic acid and ellagitannins containing pomegranate and walnuts. Here, we assessed the potential antileukemic activities of both urolithin A and urolithin B. Results showed that both urolithin A and B significantly inhibited the proliferation of leukemic cell lines Jurkat and K562, among which urolithin A showed the more prominent antiproliferative capability. Further, urolithin treatment alters leukemic cell metabolism, as evidenced by increased metabolic rate and notable changes in glutamine metabolism, one-carbon metabolism, and lipid metabolism. Next, we evidenced that both urolithins equally promoted apoptosis in leukemic cell lines. Based on these observations, we concluded that both urolithin A and B alter leukemic cell metabolome, resulting in a halt of proliferation, followed by apoptosis. The data can be used for designing new combinational therapies to eradicate leukemic cells. MDPI 2021-05-22 /pmc/articles/PMC8196872/ /pubmed/34067305 http://dx.doi.org/10.3390/ijms22115465 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Alzahrani, Abdulaziz Musa Shait Mohammed, Mohammed Razeeth Alghamdi, Raed Ahmed Ahmad, Abrar Zamzami, Mazin A. Choudhry, Hani Khan, Mohammad Imran Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells |
title | Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells |
title_full | Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells |
title_fullStr | Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells |
title_full_unstemmed | Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells |
title_short | Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells |
title_sort | urolithin a and b alter cellular metabolism and induce metabolites associated with apoptosis in leukemic cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196872/ https://www.ncbi.nlm.nih.gov/pubmed/34067305 http://dx.doi.org/10.3390/ijms22115465 |
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