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Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells

Leukemia is persistently a significant cause of illness and mortality worldwide. Urolithins, metabolites of ellagic acid and ellagitannins produced by gut microbiota, showed better bioactive compounds liable for the health benefits exerted by ellagic acid and ellagitannins containing pomegranate and...

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Autores principales: Alzahrani, Abdulaziz Musa, Shait Mohammed, Mohammed Razeeth, Alghamdi, Raed Ahmed, Ahmad, Abrar, Zamzami, Mazin A., Choudhry, Hani, Khan, Mohammad Imran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196872/
https://www.ncbi.nlm.nih.gov/pubmed/34067305
http://dx.doi.org/10.3390/ijms22115465
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author Alzahrani, Abdulaziz Musa
Shait Mohammed, Mohammed Razeeth
Alghamdi, Raed Ahmed
Ahmad, Abrar
Zamzami, Mazin A.
Choudhry, Hani
Khan, Mohammad Imran
author_facet Alzahrani, Abdulaziz Musa
Shait Mohammed, Mohammed Razeeth
Alghamdi, Raed Ahmed
Ahmad, Abrar
Zamzami, Mazin A.
Choudhry, Hani
Khan, Mohammad Imran
author_sort Alzahrani, Abdulaziz Musa
collection PubMed
description Leukemia is persistently a significant cause of illness and mortality worldwide. Urolithins, metabolites of ellagic acid and ellagitannins produced by gut microbiota, showed better bioactive compounds liable for the health benefits exerted by ellagic acid and ellagitannins containing pomegranate and walnuts. Here, we assessed the potential antileukemic activities of both urolithin A and urolithin B. Results showed that both urolithin A and B significantly inhibited the proliferation of leukemic cell lines Jurkat and K562, among which urolithin A showed the more prominent antiproliferative capability. Further, urolithin treatment alters leukemic cell metabolism, as evidenced by increased metabolic rate and notable changes in glutamine metabolism, one-carbon metabolism, and lipid metabolism. Next, we evidenced that both urolithins equally promoted apoptosis in leukemic cell lines. Based on these observations, we concluded that both urolithin A and B alter leukemic cell metabolome, resulting in a halt of proliferation, followed by apoptosis. The data can be used for designing new combinational therapies to eradicate leukemic cells.
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spelling pubmed-81968722021-06-13 Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells Alzahrani, Abdulaziz Musa Shait Mohammed, Mohammed Razeeth Alghamdi, Raed Ahmed Ahmad, Abrar Zamzami, Mazin A. Choudhry, Hani Khan, Mohammad Imran Int J Mol Sci Article Leukemia is persistently a significant cause of illness and mortality worldwide. Urolithins, metabolites of ellagic acid and ellagitannins produced by gut microbiota, showed better bioactive compounds liable for the health benefits exerted by ellagic acid and ellagitannins containing pomegranate and walnuts. Here, we assessed the potential antileukemic activities of both urolithin A and urolithin B. Results showed that both urolithin A and B significantly inhibited the proliferation of leukemic cell lines Jurkat and K562, among which urolithin A showed the more prominent antiproliferative capability. Further, urolithin treatment alters leukemic cell metabolism, as evidenced by increased metabolic rate and notable changes in glutamine metabolism, one-carbon metabolism, and lipid metabolism. Next, we evidenced that both urolithins equally promoted apoptosis in leukemic cell lines. Based on these observations, we concluded that both urolithin A and B alter leukemic cell metabolome, resulting in a halt of proliferation, followed by apoptosis. The data can be used for designing new combinational therapies to eradicate leukemic cells. MDPI 2021-05-22 /pmc/articles/PMC8196872/ /pubmed/34067305 http://dx.doi.org/10.3390/ijms22115465 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alzahrani, Abdulaziz Musa
Shait Mohammed, Mohammed Razeeth
Alghamdi, Raed Ahmed
Ahmad, Abrar
Zamzami, Mazin A.
Choudhry, Hani
Khan, Mohammad Imran
Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells
title Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells
title_full Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells
title_fullStr Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells
title_full_unstemmed Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells
title_short Urolithin A and B Alter Cellular Metabolism and Induce Metabolites Associated with Apoptosis in Leukemic Cells
title_sort urolithin a and b alter cellular metabolism and induce metabolites associated with apoptosis in leukemic cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196872/
https://www.ncbi.nlm.nih.gov/pubmed/34067305
http://dx.doi.org/10.3390/ijms22115465
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