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Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study
Colorectal adenoma is linked to metabolic dysfunction. Metabolic dysfunction-associated fatty liver disease (MAFLD) has a precise definition and three subtypes, including non-obese MAFLD. We aimed to investigate the impact of MAFLD on the prevalence of colorectal adenoma by comparing it to non-alcoh...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196881/ https://www.ncbi.nlm.nih.gov/pubmed/34067258 http://dx.doi.org/10.3390/ijms22115462 |
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author | Fukunaga, Shuhei Nakano, Dan Kawaguchi, Takumi Eslam, Mohammed Ouchi, Akihiro Nagata, Tsutomu Kuroki, Hidefumi Kawata, Hidemichi Abe, Hirohiko Nouno, Ryuichi Kawaguchi, Koutaro George, Jacob Mitsuyama, Keiichi Torimura, Takuji |
author_facet | Fukunaga, Shuhei Nakano, Dan Kawaguchi, Takumi Eslam, Mohammed Ouchi, Akihiro Nagata, Tsutomu Kuroki, Hidefumi Kawata, Hidemichi Abe, Hirohiko Nouno, Ryuichi Kawaguchi, Koutaro George, Jacob Mitsuyama, Keiichi Torimura, Takuji |
author_sort | Fukunaga, Shuhei |
collection | PubMed |
description | Colorectal adenoma is linked to metabolic dysfunction. Metabolic dysfunction-associated fatty liver disease (MAFLD) has a precise definition and three subtypes, including non-obese MAFLD. We aimed to investigate the impact of MAFLD on the prevalence of colorectal adenoma by comparing it to non-alcoholic fatty liver disease (NAFLD) in health check-up examinees. This is a multicenter retrospective study. We enrolled 124 consecutive health check-up examinees who underwent colonoscopy. NAFLD and MAFLD were present in 58 and 63 examinees, respectively. Colorectal adenoma was diagnosed by biopsy. The impact of the MAFLD definition on the prevalence of colorectal adenoma was investigated by logistic regression, decision-tree, and random forest analyses. In logistic regression analysis, MAFLD was identified as the only independent factor associated with the presence of colorectal adenoma (OR 3.191; 95% CI 1.494–7.070; p = 0.003). MAFLD was also identified as the most important classifier for the presence of colorectal adenoma in decision-tree and random forest analyses (29 variable importance value). Among the three subtypes of MAFLD, non-obese MAFLD was the sole independent factor associated with the presence of colorectal adenoma (OR 3.351; 95% CI 1.589–7.262; p ≤ 0.001). Non-obese MAFLD was also the most important classifier for the presence of colorectal adenoma in decision-tree and random forest analyses (31 variable importance value). MAFLD, particularly non-obese MAFLD, is the most important factor associated with the presence of colorectal adenoma rather than NAFLD. Colonoscopy examination should be considered in patients with MAFLD, especially those who are non-obese. |
format | Online Article Text |
id | pubmed-8196881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81968812021-06-13 Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study Fukunaga, Shuhei Nakano, Dan Kawaguchi, Takumi Eslam, Mohammed Ouchi, Akihiro Nagata, Tsutomu Kuroki, Hidefumi Kawata, Hidemichi Abe, Hirohiko Nouno, Ryuichi Kawaguchi, Koutaro George, Jacob Mitsuyama, Keiichi Torimura, Takuji Int J Mol Sci Article Colorectal adenoma is linked to metabolic dysfunction. Metabolic dysfunction-associated fatty liver disease (MAFLD) has a precise definition and three subtypes, including non-obese MAFLD. We aimed to investigate the impact of MAFLD on the prevalence of colorectal adenoma by comparing it to non-alcoholic fatty liver disease (NAFLD) in health check-up examinees. This is a multicenter retrospective study. We enrolled 124 consecutive health check-up examinees who underwent colonoscopy. NAFLD and MAFLD were present in 58 and 63 examinees, respectively. Colorectal adenoma was diagnosed by biopsy. The impact of the MAFLD definition on the prevalence of colorectal adenoma was investigated by logistic regression, decision-tree, and random forest analyses. In logistic regression analysis, MAFLD was identified as the only independent factor associated with the presence of colorectal adenoma (OR 3.191; 95% CI 1.494–7.070; p = 0.003). MAFLD was also identified as the most important classifier for the presence of colorectal adenoma in decision-tree and random forest analyses (29 variable importance value). Among the three subtypes of MAFLD, non-obese MAFLD was the sole independent factor associated with the presence of colorectal adenoma (OR 3.351; 95% CI 1.589–7.262; p ≤ 0.001). Non-obese MAFLD was also the most important classifier for the presence of colorectal adenoma in decision-tree and random forest analyses (31 variable importance value). MAFLD, particularly non-obese MAFLD, is the most important factor associated with the presence of colorectal adenoma rather than NAFLD. Colonoscopy examination should be considered in patients with MAFLD, especially those who are non-obese. MDPI 2021-05-22 /pmc/articles/PMC8196881/ /pubmed/34067258 http://dx.doi.org/10.3390/ijms22115462 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Fukunaga, Shuhei Nakano, Dan Kawaguchi, Takumi Eslam, Mohammed Ouchi, Akihiro Nagata, Tsutomu Kuroki, Hidefumi Kawata, Hidemichi Abe, Hirohiko Nouno, Ryuichi Kawaguchi, Koutaro George, Jacob Mitsuyama, Keiichi Torimura, Takuji Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study |
title | Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study |
title_full | Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study |
title_fullStr | Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study |
title_full_unstemmed | Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study |
title_short | Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study |
title_sort | non-obese mafld is associated with colorectal adenoma in health check examinees: a multicenter retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196881/ https://www.ncbi.nlm.nih.gov/pubmed/34067258 http://dx.doi.org/10.3390/ijms22115462 |
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