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Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study

Colorectal adenoma is linked to metabolic dysfunction. Metabolic dysfunction-associated fatty liver disease (MAFLD) has a precise definition and three subtypes, including non-obese MAFLD. We aimed to investigate the impact of MAFLD on the prevalence of colorectal adenoma by comparing it to non-alcoh...

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Autores principales: Fukunaga, Shuhei, Nakano, Dan, Kawaguchi, Takumi, Eslam, Mohammed, Ouchi, Akihiro, Nagata, Tsutomu, Kuroki, Hidefumi, Kawata, Hidemichi, Abe, Hirohiko, Nouno, Ryuichi, Kawaguchi, Koutaro, George, Jacob, Mitsuyama, Keiichi, Torimura, Takuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196881/
https://www.ncbi.nlm.nih.gov/pubmed/34067258
http://dx.doi.org/10.3390/ijms22115462
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author Fukunaga, Shuhei
Nakano, Dan
Kawaguchi, Takumi
Eslam, Mohammed
Ouchi, Akihiro
Nagata, Tsutomu
Kuroki, Hidefumi
Kawata, Hidemichi
Abe, Hirohiko
Nouno, Ryuichi
Kawaguchi, Koutaro
George, Jacob
Mitsuyama, Keiichi
Torimura, Takuji
author_facet Fukunaga, Shuhei
Nakano, Dan
Kawaguchi, Takumi
Eslam, Mohammed
Ouchi, Akihiro
Nagata, Tsutomu
Kuroki, Hidefumi
Kawata, Hidemichi
Abe, Hirohiko
Nouno, Ryuichi
Kawaguchi, Koutaro
George, Jacob
Mitsuyama, Keiichi
Torimura, Takuji
author_sort Fukunaga, Shuhei
collection PubMed
description Colorectal adenoma is linked to metabolic dysfunction. Metabolic dysfunction-associated fatty liver disease (MAFLD) has a precise definition and three subtypes, including non-obese MAFLD. We aimed to investigate the impact of MAFLD on the prevalence of colorectal adenoma by comparing it to non-alcoholic fatty liver disease (NAFLD) in health check-up examinees. This is a multicenter retrospective study. We enrolled 124 consecutive health check-up examinees who underwent colonoscopy. NAFLD and MAFLD were present in 58 and 63 examinees, respectively. Colorectal adenoma was diagnosed by biopsy. The impact of the MAFLD definition on the prevalence of colorectal adenoma was investigated by logistic regression, decision-tree, and random forest analyses. In logistic regression analysis, MAFLD was identified as the only independent factor associated with the presence of colorectal adenoma (OR 3.191; 95% CI 1.494–7.070; p = 0.003). MAFLD was also identified as the most important classifier for the presence of colorectal adenoma in decision-tree and random forest analyses (29 variable importance value). Among the three subtypes of MAFLD, non-obese MAFLD was the sole independent factor associated with the presence of colorectal adenoma (OR 3.351; 95% CI 1.589–7.262; p ≤ 0.001). Non-obese MAFLD was also the most important classifier for the presence of colorectal adenoma in decision-tree and random forest analyses (31 variable importance value). MAFLD, particularly non-obese MAFLD, is the most important factor associated with the presence of colorectal adenoma rather than NAFLD. Colonoscopy examination should be considered in patients with MAFLD, especially those who are non-obese.
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spelling pubmed-81968812021-06-13 Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study Fukunaga, Shuhei Nakano, Dan Kawaguchi, Takumi Eslam, Mohammed Ouchi, Akihiro Nagata, Tsutomu Kuroki, Hidefumi Kawata, Hidemichi Abe, Hirohiko Nouno, Ryuichi Kawaguchi, Koutaro George, Jacob Mitsuyama, Keiichi Torimura, Takuji Int J Mol Sci Article Colorectal adenoma is linked to metabolic dysfunction. Metabolic dysfunction-associated fatty liver disease (MAFLD) has a precise definition and three subtypes, including non-obese MAFLD. We aimed to investigate the impact of MAFLD on the prevalence of colorectal adenoma by comparing it to non-alcoholic fatty liver disease (NAFLD) in health check-up examinees. This is a multicenter retrospective study. We enrolled 124 consecutive health check-up examinees who underwent colonoscopy. NAFLD and MAFLD were present in 58 and 63 examinees, respectively. Colorectal adenoma was diagnosed by biopsy. The impact of the MAFLD definition on the prevalence of colorectal adenoma was investigated by logistic regression, decision-tree, and random forest analyses. In logistic regression analysis, MAFLD was identified as the only independent factor associated with the presence of colorectal adenoma (OR 3.191; 95% CI 1.494–7.070; p = 0.003). MAFLD was also identified as the most important classifier for the presence of colorectal adenoma in decision-tree and random forest analyses (29 variable importance value). Among the three subtypes of MAFLD, non-obese MAFLD was the sole independent factor associated with the presence of colorectal adenoma (OR 3.351; 95% CI 1.589–7.262; p ≤ 0.001). Non-obese MAFLD was also the most important classifier for the presence of colorectal adenoma in decision-tree and random forest analyses (31 variable importance value). MAFLD, particularly non-obese MAFLD, is the most important factor associated with the presence of colorectal adenoma rather than NAFLD. Colonoscopy examination should be considered in patients with MAFLD, especially those who are non-obese. MDPI 2021-05-22 /pmc/articles/PMC8196881/ /pubmed/34067258 http://dx.doi.org/10.3390/ijms22115462 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fukunaga, Shuhei
Nakano, Dan
Kawaguchi, Takumi
Eslam, Mohammed
Ouchi, Akihiro
Nagata, Tsutomu
Kuroki, Hidefumi
Kawata, Hidemichi
Abe, Hirohiko
Nouno, Ryuichi
Kawaguchi, Koutaro
George, Jacob
Mitsuyama, Keiichi
Torimura, Takuji
Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study
title Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study
title_full Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study
title_fullStr Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study
title_full_unstemmed Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study
title_short Non-Obese MAFLD Is Associated with Colorectal Adenoma in Health Check Examinees: A Multicenter Retrospective Study
title_sort non-obese mafld is associated with colorectal adenoma in health check examinees: a multicenter retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8196881/
https://www.ncbi.nlm.nih.gov/pubmed/34067258
http://dx.doi.org/10.3390/ijms22115462
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