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Ubiquitination and Deubiquitination in Oral Disease
Oral health is an integral part of the general health and well-being of individuals. The presence of oral disease is potentially indicative of a number of systemic diseases and may contribute to their early diagnosis and treatment. The ubiquitin (Ub) system has been shown to play a role in cellular...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197098/ https://www.ncbi.nlm.nih.gov/pubmed/34070986 http://dx.doi.org/10.3390/ijms22115488 |
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author | Tsuchida, Sachio Nakayama, Tomohiro |
author_facet | Tsuchida, Sachio Nakayama, Tomohiro |
author_sort | Tsuchida, Sachio |
collection | PubMed |
description | Oral health is an integral part of the general health and well-being of individuals. The presence of oral disease is potentially indicative of a number of systemic diseases and may contribute to their early diagnosis and treatment. The ubiquitin (Ub) system has been shown to play a role in cellular immune response, cellular development, and programmed cell death. Ubiquitination is a post-translational modification that occurs in eukaryotes. Its mechanism involves a number of factors, including Ub-activating enzymes, Ub-conjugating enzymes, and Ub protein ligases. Deubiquitinating enzymes, which are proteases that reversely modify proteins by removing Ub or Ub-like molecules or remodeling Ub chains on target proteins, have recently been regarded as crucial regulators of ubiquitination-mediated degradation and are known to significantly affect cellular pathways, a number of biological processes, DNA damage response, and DNA repair pathways. Research has increasingly shown evidence of the relationship between ubiquitination, deubiquitination, and oral disease. This review investigates recent progress in discoveries in diseased oral sites and discusses the roles of ubiquitination and deubiquitination in oral disease. |
format | Online Article Text |
id | pubmed-8197098 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81970982021-06-13 Ubiquitination and Deubiquitination in Oral Disease Tsuchida, Sachio Nakayama, Tomohiro Int J Mol Sci Review Oral health is an integral part of the general health and well-being of individuals. The presence of oral disease is potentially indicative of a number of systemic diseases and may contribute to their early diagnosis and treatment. The ubiquitin (Ub) system has been shown to play a role in cellular immune response, cellular development, and programmed cell death. Ubiquitination is a post-translational modification that occurs in eukaryotes. Its mechanism involves a number of factors, including Ub-activating enzymes, Ub-conjugating enzymes, and Ub protein ligases. Deubiquitinating enzymes, which are proteases that reversely modify proteins by removing Ub or Ub-like molecules or remodeling Ub chains on target proteins, have recently been regarded as crucial regulators of ubiquitination-mediated degradation and are known to significantly affect cellular pathways, a number of biological processes, DNA damage response, and DNA repair pathways. Research has increasingly shown evidence of the relationship between ubiquitination, deubiquitination, and oral disease. This review investigates recent progress in discoveries in diseased oral sites and discusses the roles of ubiquitination and deubiquitination in oral disease. MDPI 2021-05-23 /pmc/articles/PMC8197098/ /pubmed/34070986 http://dx.doi.org/10.3390/ijms22115488 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Tsuchida, Sachio Nakayama, Tomohiro Ubiquitination and Deubiquitination in Oral Disease |
title | Ubiquitination and Deubiquitination in Oral Disease |
title_full | Ubiquitination and Deubiquitination in Oral Disease |
title_fullStr | Ubiquitination and Deubiquitination in Oral Disease |
title_full_unstemmed | Ubiquitination and Deubiquitination in Oral Disease |
title_short | Ubiquitination and Deubiquitination in Oral Disease |
title_sort | ubiquitination and deubiquitination in oral disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197098/ https://www.ncbi.nlm.nih.gov/pubmed/34070986 http://dx.doi.org/10.3390/ijms22115488 |
work_keys_str_mv | AT tsuchidasachio ubiquitinationanddeubiquitinationinoraldisease AT nakayamatomohiro ubiquitinationanddeubiquitinationinoraldisease |