Cargando…

Ubiquitination and Deubiquitination in Oral Disease

Oral health is an integral part of the general health and well-being of individuals. The presence of oral disease is potentially indicative of a number of systemic diseases and may contribute to their early diagnosis and treatment. The ubiquitin (Ub) system has been shown to play a role in cellular...

Descripción completa

Detalles Bibliográficos
Autores principales: Tsuchida, Sachio, Nakayama, Tomohiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197098/
https://www.ncbi.nlm.nih.gov/pubmed/34070986
http://dx.doi.org/10.3390/ijms22115488
_version_ 1783706841102942208
author Tsuchida, Sachio
Nakayama, Tomohiro
author_facet Tsuchida, Sachio
Nakayama, Tomohiro
author_sort Tsuchida, Sachio
collection PubMed
description Oral health is an integral part of the general health and well-being of individuals. The presence of oral disease is potentially indicative of a number of systemic diseases and may contribute to their early diagnosis and treatment. The ubiquitin (Ub) system has been shown to play a role in cellular immune response, cellular development, and programmed cell death. Ubiquitination is a post-translational modification that occurs in eukaryotes. Its mechanism involves a number of factors, including Ub-activating enzymes, Ub-conjugating enzymes, and Ub protein ligases. Deubiquitinating enzymes, which are proteases that reversely modify proteins by removing Ub or Ub-like molecules or remodeling Ub chains on target proteins, have recently been regarded as crucial regulators of ubiquitination-mediated degradation and are known to significantly affect cellular pathways, a number of biological processes, DNA damage response, and DNA repair pathways. Research has increasingly shown evidence of the relationship between ubiquitination, deubiquitination, and oral disease. This review investigates recent progress in discoveries in diseased oral sites and discusses the roles of ubiquitination and deubiquitination in oral disease.
format Online
Article
Text
id pubmed-8197098
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81970982021-06-13 Ubiquitination and Deubiquitination in Oral Disease Tsuchida, Sachio Nakayama, Tomohiro Int J Mol Sci Review Oral health is an integral part of the general health and well-being of individuals. The presence of oral disease is potentially indicative of a number of systemic diseases and may contribute to their early diagnosis and treatment. The ubiquitin (Ub) system has been shown to play a role in cellular immune response, cellular development, and programmed cell death. Ubiquitination is a post-translational modification that occurs in eukaryotes. Its mechanism involves a number of factors, including Ub-activating enzymes, Ub-conjugating enzymes, and Ub protein ligases. Deubiquitinating enzymes, which are proteases that reversely modify proteins by removing Ub or Ub-like molecules or remodeling Ub chains on target proteins, have recently been regarded as crucial regulators of ubiquitination-mediated degradation and are known to significantly affect cellular pathways, a number of biological processes, DNA damage response, and DNA repair pathways. Research has increasingly shown evidence of the relationship between ubiquitination, deubiquitination, and oral disease. This review investigates recent progress in discoveries in diseased oral sites and discusses the roles of ubiquitination and deubiquitination in oral disease. MDPI 2021-05-23 /pmc/articles/PMC8197098/ /pubmed/34070986 http://dx.doi.org/10.3390/ijms22115488 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Tsuchida, Sachio
Nakayama, Tomohiro
Ubiquitination and Deubiquitination in Oral Disease
title Ubiquitination and Deubiquitination in Oral Disease
title_full Ubiquitination and Deubiquitination in Oral Disease
title_fullStr Ubiquitination and Deubiquitination in Oral Disease
title_full_unstemmed Ubiquitination and Deubiquitination in Oral Disease
title_short Ubiquitination and Deubiquitination in Oral Disease
title_sort ubiquitination and deubiquitination in oral disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197098/
https://www.ncbi.nlm.nih.gov/pubmed/34070986
http://dx.doi.org/10.3390/ijms22115488
work_keys_str_mv AT tsuchidasachio ubiquitinationanddeubiquitinationinoraldisease
AT nakayamatomohiro ubiquitinationanddeubiquitinationinoraldisease