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The Crossroads between Host Copper Metabolism and Influenza Infection

Three main approaches are used to combat severe viral respiratory infections. The first is preemptive vaccination that blocks infection. Weakened or dead viral particles, as well as genetic constructs carrying viral proteins or information about them, are used as an antigen. However, the viral genom...

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Autores principales: Puchkova, Ludmila V., Kiseleva, Irina V., Polishchuk, Elena V., Broggini, Massimo, Ilyechova, Ekaterina Yu.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197124/
https://www.ncbi.nlm.nih.gov/pubmed/34071094
http://dx.doi.org/10.3390/ijms22115498
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author Puchkova, Ludmila V.
Kiseleva, Irina V.
Polishchuk, Elena V.
Broggini, Massimo
Ilyechova, Ekaterina Yu.
author_facet Puchkova, Ludmila V.
Kiseleva, Irina V.
Polishchuk, Elena V.
Broggini, Massimo
Ilyechova, Ekaterina Yu.
author_sort Puchkova, Ludmila V.
collection PubMed
description Three main approaches are used to combat severe viral respiratory infections. The first is preemptive vaccination that blocks infection. Weakened or dead viral particles, as well as genetic constructs carrying viral proteins or information about them, are used as an antigen. However, the viral genome is very evolutionary labile and changes continuously. Second, chemical agents are used during infection and inhibit the function of a number of viral proteins. However, these drugs lose their effectiveness because the virus can rapidly acquire resistance to them. The third is the search for points in the host metabolism the effect on which would suppress the replication of the virus but would not have a significant effect on the metabolism of the host. Here, we consider the possibility of using the copper metabolic system as a target to reduce the severity of influenza infection. This is facilitated by the fact that, in mammals, copper status can be rapidly reduced by silver nanoparticles and restored after their cancellation.
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spelling pubmed-81971242021-06-13 The Crossroads between Host Copper Metabolism and Influenza Infection Puchkova, Ludmila V. Kiseleva, Irina V. Polishchuk, Elena V. Broggini, Massimo Ilyechova, Ekaterina Yu. Int J Mol Sci Review Three main approaches are used to combat severe viral respiratory infections. The first is preemptive vaccination that blocks infection. Weakened or dead viral particles, as well as genetic constructs carrying viral proteins or information about them, are used as an antigen. However, the viral genome is very evolutionary labile and changes continuously. Second, chemical agents are used during infection and inhibit the function of a number of viral proteins. However, these drugs lose their effectiveness because the virus can rapidly acquire resistance to them. The third is the search for points in the host metabolism the effect on which would suppress the replication of the virus but would not have a significant effect on the metabolism of the host. Here, we consider the possibility of using the copper metabolic system as a target to reduce the severity of influenza infection. This is facilitated by the fact that, in mammals, copper status can be rapidly reduced by silver nanoparticles and restored after their cancellation. MDPI 2021-05-23 /pmc/articles/PMC8197124/ /pubmed/34071094 http://dx.doi.org/10.3390/ijms22115498 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Puchkova, Ludmila V.
Kiseleva, Irina V.
Polishchuk, Elena V.
Broggini, Massimo
Ilyechova, Ekaterina Yu.
The Crossroads between Host Copper Metabolism and Influenza Infection
title The Crossroads between Host Copper Metabolism and Influenza Infection
title_full The Crossroads between Host Copper Metabolism and Influenza Infection
title_fullStr The Crossroads between Host Copper Metabolism and Influenza Infection
title_full_unstemmed The Crossroads between Host Copper Metabolism and Influenza Infection
title_short The Crossroads between Host Copper Metabolism and Influenza Infection
title_sort crossroads between host copper metabolism and influenza infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197124/
https://www.ncbi.nlm.nih.gov/pubmed/34071094
http://dx.doi.org/10.3390/ijms22115498
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