Cargando…

Enantioselectivity in Drug Pharmacokinetics and Toxicity: Pharmacological Relevance and Analytical Methods

Enzymes, receptors, and other binding molecules in biological processes can recognize enantiomers as different molecular entities, due to their different dissociation constants, leading to diverse responses in biological processes. Enantioselectivity can be observed in drugs pharmacodynamics and in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Coelho, Maria Miguel, Fernandes, Carla, Remião, Fernando, Tiritan, Maria Elizabeth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197169/ https://www.ncbi.nlm.nih.gov/pubmed/34070985 http://dx.doi.org/10.3390/molecules26113113

Ejemplares similares

Enantioselective Synthesis, Enantiomeric Separations and Chiral Recognition
por: Tiritan, Maria Elizabeth, et al.
Publicado: (2020)

Chiral enantioresolution of cathinone derivatives present in “legal highs”, and enantioselectivity evaluation on cytotoxicity of 3,4-methylenedioxypyrovalerone (MDPV)
por: Silva, Bárbara, et al.
Publicado: (2016)

Synthetic Cathinones: Recent Developments, Enantioselectivity Studies and Enantioseparation Methods
por: Almeida, Ana Sofia, et al.
Publicado: (2022)

Synthetic Chiral Derivatives of Xanthones: Biological Activities and Enantioselectivity Studies
por: Fernandes, Carla, et al.
Publicado: (2019)

Sinapis Semen: A review on phytochemistry, pharmacology, toxicity, analytical methods and pharmacokinetics
por: Dang, Rui, et al.
Publicado: (2023)

Assessment of the Permeability of 3,4-Methylenedioxypyrovalerone (MDPV) across the Caco-2 Monolayer for Estimation of Intestinal Absorption and Enantioselectivity
por: Almeida, Ana Sofia, et al.
Publicado: (2023)

Enantioselectivity of Chiral Derivatives of Xanthones in Virulence Effects of Resistant Bacteria
por: Durães, Fernando, et al.
Publicado: (2021)

Chiral Thioxanthones as Modulators of P-glycoprotein: Synthesis and Enantioselectivity Studies
por: Lopes, Ana, et al.
Publicado: (2018)

Strategies for Preparation of Chiral Stationary Phases: Progress on Coating and Immobilization Methods
por: Fernandes, Carla, et al.
Publicado: (2021)

Enantioselectivity of Pentedrone and Methylone on Metabolic Profiling in 2D and 3D Human Hepatocyte-like Cells
por: Silva, Bárbara, et al.
Publicado: (2022)

Chiral Derivatives of Xanthones: Investigation of the Effect of Enantioselectivity on Inhibition of Cyclooxygenases (COX-1 and COX-2) and Binding Interaction with Human Serum Albumin
por: Fernandes, Carla, et al.
Publicado: (2017)

Pharmacology, toxicity and pharmacokinetics of acetylshikonin: a review
por: Zhang, Zhiqin, et al.
Publicado: (2020)

Chiral Derivatives of Xanthones with Antimicrobial Activity
por: Araújo, Joana, et al.
Publicado: (2019)

Natural Sympathomimetic Drugs: From Pharmacology to Toxicology
por: Costa, Vera Marisa, et al.
Publicado: (2022)

Enantioselective transformation of fluoxetine in water and its ecotoxicological relevance
por: Andrés-Costa, María Jesús, et al.
Publicado: (2017)

Enantioselective Pharmacokinetics of α-Lipoic Acid in Rats
por: Uchida, Ryota, et al.
Publicado: (2015)

Ayahuasca as a Decoction Applied to Human: Analytical Methods, Pharmacology and Potential Toxic Effects
por: Nižnanský, Ľuboš, et al.
Publicado: (2022)

Limonin: A Review of Its Pharmacology, Toxicity, and Pharmacokinetics
por: Fan, Shunming, et al.
Publicado: (2019)

Jatrorrhizine: A Review of Sources, Pharmacology, Pharmacokinetics and Toxicity
por: Zhong, Furong, et al.
Publicado: (2022)

Oridonin: A Review of Its Pharmacology, Pharmacokinetics and Toxicity
por: Li, Xiang, et al.
Publicado: (2021)

The pharmacology, pharmacokinetics, and toxicity of spinosin: A mini review
por: Kuang, Xiaolan, et al.
Publicado: (2022)

Chiral Stationary Phases for Liquid Chromatography: Recent Developments
por: Teixeira, Joana, et al.
Publicado: (2019)

Preface for special issue on new analytical techniques and methods in drug metabolism and pharmacokinetics
por: Ge, Guangbo, et al.
Publicado: (2020)

Tectorigenin: A Review of Its Sources, Pharmacology, Toxicity, and Pharmacokinetics
por: Rong, Juan, et al.
Publicado: (2023)

Chiral Separations in Preparative Scale: A Medicinal Chemistry Point of View
por: Pinto, Madalena M.M., et al.
Publicado: (2020)

Kale Extract Increases Glutathione Levels in V79 Cells, but Does not Protect Them Against Acute Toxicity Induced by Hydrogen Peroxide
por: Fernandes, Fátima, et al.
Publicado: (2012)

Pharmacokinetic relevance of glomerular hyperfiltration for drug dosing
por: Zoccali, Carmine, et al.
Publicado: (2023)

Carboxyxanthones: Bioactive Agents and Molecular Scaffold for Synthesis of Analogues and Derivatives
por: Ribeiro, João, et al.
Publicado: (2019)

Enantioselective Drug Recognition by Drug Transporters
por: Uwai, Yuichi
Publicado: (2018)

A Mechanistic, Enantioselective, Physiologically Based Pharmacokinetic Model of Verapamil and Norverapamil, Built and Evaluated for Drug–Drug Interaction Studies
por: Hanke, Nina, et al.
Publicado: (2020)

Research Progress in the Pharmacological Activities, Toxicities, and Pharmacokinetics of Sophoridine and Its Derivatives
por: Tang, Qiong, et al.
Publicado: (2022)

Hyperoside: A Review of Its Structure, Synthesis, Pharmacology, Pharmacokinetics and Toxicity
por: Xu, Sijin, et al.
Publicado: (2022)

Effects of drug pharmacokinetic/pharmacodynamic properties, characteristics of medication use, and relevant pharmacological interventions on fall risk in elderly patients
por: Chen, Ying, et al.
Publicado: (2014)

Enantioselective Toxic Effects of Prothioconazole toward Scenedesmus obliquus
por: Xiang, Qingqing, et al.
Publicado: (2023)

Pharmacokinetic Interactions between Herbal Medicines and Drugs: Their Mechanisms and Clinical Relevance
por: Rombolà, Laura, et al.
Publicado: (2020)

A Review of the Botany, Traditional Use, Phytochemistry, Analytical Methods, Pharmacological Effects, and Toxicity of Angelicae Pubescentis Radix
por: Yang, Liu, et al.
Publicado: (2020)

Comprehensive review of cardiovascular toxicity of drugs and related agents
por: Mladěnka, Přemysl, et al.
Publicado: (2018)

Sesquiterpene lactones of Aucklandia lappa: Pharmacology, pharmacokinetics, toxicity, and structure–activity relationship
por: Liu, Xin-nan, et al.
Publicado: (2021)

Chiral Drug Analysis in Forensic Chemistry: An Overview
por: Ribeiro, Cláudia, et al.
Publicado: (2018)

A review of the botany, ethnopharmacology, phytochemistry, analysis method and quality control, processing methods, pharmacological effects, pharmacokinetics and toxicity of codonopsis radix
por: Dong, Jiaojiao, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_r26apskg7eipj0l025jt0pv32e