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A Systematic Review about Imaging and Histopathological Findings for Detecting and Evaluating Electroporation Based Treatments Response

Background: Imaging methods and the most appropriate criteria to be used for detecting and evaluating response to oncological treatments depend on the pathology and anatomical site to be treated and on the treatment to be performed. This document provides a general overview of the main imaging and h...

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Autores principales: Granata, Vincenza, Fusco, Roberta, Salati, Simona, Petrillo, Antonella, Di Bernardo, Elio, Grassi, Roberta, Palaia, Raffaele, Danti, Ginevra, La Porta, Michelearcangelo, Cadossi, Matteo, Gašljević, Gorana, Sersa, Gregor, Izzo, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197272/
https://www.ncbi.nlm.nih.gov/pubmed/34073865
http://dx.doi.org/10.3390/ijerph18115592
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author Granata, Vincenza
Fusco, Roberta
Salati, Simona
Petrillo, Antonella
Di Bernardo, Elio
Grassi, Roberta
Palaia, Raffaele
Danti, Ginevra
La Porta, Michelearcangelo
Cadossi, Matteo
Gašljević, Gorana
Sersa, Gregor
Izzo, Francesco
author_facet Granata, Vincenza
Fusco, Roberta
Salati, Simona
Petrillo, Antonella
Di Bernardo, Elio
Grassi, Roberta
Palaia, Raffaele
Danti, Ginevra
La Porta, Michelearcangelo
Cadossi, Matteo
Gašljević, Gorana
Sersa, Gregor
Izzo, Francesco
author_sort Granata, Vincenza
collection PubMed
description Background: Imaging methods and the most appropriate criteria to be used for detecting and evaluating response to oncological treatments depend on the pathology and anatomical site to be treated and on the treatment to be performed. This document provides a general overview of the main imaging and histopathological findings of electroporation-based treatments (Electrochemotherapy—ECT and Irreversible electroporation—IRE) compared to thermal approach, such as radiofrequency ablation (RFA), in deep-seated cancers with a particular attention to pancreatic and liver cancer. Methods: Numerous electronic datasets were examined: PubMed, Scopus, Web of Science and Google Scholar. The research covered the years from January 1990 to April 2021. All titles and abstracts were analyzed. The inclusion criteria were the following: studies that report imaging or histopathological findings after ablative thermal and not thermal loco-regional treatments (ECT, IRE, RFA) in deep-seated cancers including pancreatic and liver cancer and articles published in the English language. Exclusion criteria were unavailability of full text and congress abstracts or posters and different topic respect to inclusion criteria. Results: 558 potentially relevant references through electronic searches were identified. A total of 38 articles met the inclusion criteria: 20 studies report imaging findings after RFA or ECT or IRE in pancreatic and liver cancer; 17 studies report histopathological findings after RFA or ECT or IRE; 1 study reports both imaging and histopathological findings after RFA or ECT or IRE. Conclusions: Imaging features are related to the type of therapy administrated, to the timing of re-assessment post therapy and to the imaging technique being used to observe the effects. Histological findings after both ECT and IRE show that the treated area becomes necrotic and encapsulated in fibrous tissue, suggesting that the size of the treated lesion cannot be measured as an endpoint to detect response. Moreover, histology frequently reported signs of apoptosis and reduced vital tissue, implying that imaging criteria, which take into account the viability and not the size of the lesion, are more appropriate to evaluate response to treatment.
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spelling pubmed-81972722021-06-13 A Systematic Review about Imaging and Histopathological Findings for Detecting and Evaluating Electroporation Based Treatments Response Granata, Vincenza Fusco, Roberta Salati, Simona Petrillo, Antonella Di Bernardo, Elio Grassi, Roberta Palaia, Raffaele Danti, Ginevra La Porta, Michelearcangelo Cadossi, Matteo Gašljević, Gorana Sersa, Gregor Izzo, Francesco Int J Environ Res Public Health Systematic Review Background: Imaging methods and the most appropriate criteria to be used for detecting and evaluating response to oncological treatments depend on the pathology and anatomical site to be treated and on the treatment to be performed. This document provides a general overview of the main imaging and histopathological findings of electroporation-based treatments (Electrochemotherapy—ECT and Irreversible electroporation—IRE) compared to thermal approach, such as radiofrequency ablation (RFA), in deep-seated cancers with a particular attention to pancreatic and liver cancer. Methods: Numerous electronic datasets were examined: PubMed, Scopus, Web of Science and Google Scholar. The research covered the years from January 1990 to April 2021. All titles and abstracts were analyzed. The inclusion criteria were the following: studies that report imaging or histopathological findings after ablative thermal and not thermal loco-regional treatments (ECT, IRE, RFA) in deep-seated cancers including pancreatic and liver cancer and articles published in the English language. Exclusion criteria were unavailability of full text and congress abstracts or posters and different topic respect to inclusion criteria. Results: 558 potentially relevant references through electronic searches were identified. A total of 38 articles met the inclusion criteria: 20 studies report imaging findings after RFA or ECT or IRE in pancreatic and liver cancer; 17 studies report histopathological findings after RFA or ECT or IRE; 1 study reports both imaging and histopathological findings after RFA or ECT or IRE. Conclusions: Imaging features are related to the type of therapy administrated, to the timing of re-assessment post therapy and to the imaging technique being used to observe the effects. Histological findings after both ECT and IRE show that the treated area becomes necrotic and encapsulated in fibrous tissue, suggesting that the size of the treated lesion cannot be measured as an endpoint to detect response. Moreover, histology frequently reported signs of apoptosis and reduced vital tissue, implying that imaging criteria, which take into account the viability and not the size of the lesion, are more appropriate to evaluate response to treatment. MDPI 2021-05-24 /pmc/articles/PMC8197272/ /pubmed/34073865 http://dx.doi.org/10.3390/ijerph18115592 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Granata, Vincenza
Fusco, Roberta
Salati, Simona
Petrillo, Antonella
Di Bernardo, Elio
Grassi, Roberta
Palaia, Raffaele
Danti, Ginevra
La Porta, Michelearcangelo
Cadossi, Matteo
Gašljević, Gorana
Sersa, Gregor
Izzo, Francesco
A Systematic Review about Imaging and Histopathological Findings for Detecting and Evaluating Electroporation Based Treatments Response
title A Systematic Review about Imaging and Histopathological Findings for Detecting and Evaluating Electroporation Based Treatments Response
title_full A Systematic Review about Imaging and Histopathological Findings for Detecting and Evaluating Electroporation Based Treatments Response
title_fullStr A Systematic Review about Imaging and Histopathological Findings for Detecting and Evaluating Electroporation Based Treatments Response
title_full_unstemmed A Systematic Review about Imaging and Histopathological Findings for Detecting and Evaluating Electroporation Based Treatments Response
title_short A Systematic Review about Imaging and Histopathological Findings for Detecting and Evaluating Electroporation Based Treatments Response
title_sort systematic review about imaging and histopathological findings for detecting and evaluating electroporation based treatments response
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197272/
https://www.ncbi.nlm.nih.gov/pubmed/34073865
http://dx.doi.org/10.3390/ijerph18115592
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