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Major Left Bundle Branch Block and Coronary Heart Disease—Are There Any Differences between the Sexes?

Left bundle branch block is not a benign pathology, and its presence requires the identification of a pathological substrate, such as ischemic heart disease. Left bundle branch block appears to be more commonly associated with normal coronary arteries, especially in women. The objectives of our stud...

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Autores principales: Gurzău, Diana, Dădârlat-Pop, Alexandra, Caloian, Bogdan, Cismaru, Gabriel, Comşa, Horaţiu, Tomoaia, Raluca, Zdrenghea, Dumitru, Pop, Dana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197312/
https://www.ncbi.nlm.nih.gov/pubmed/34070288
http://dx.doi.org/10.3390/jcm10112284
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author Gurzău, Diana
Dădârlat-Pop, Alexandra
Caloian, Bogdan
Cismaru, Gabriel
Comşa, Horaţiu
Tomoaia, Raluca
Zdrenghea, Dumitru
Pop, Dana
author_facet Gurzău, Diana
Dădârlat-Pop, Alexandra
Caloian, Bogdan
Cismaru, Gabriel
Comşa, Horaţiu
Tomoaia, Raluca
Zdrenghea, Dumitru
Pop, Dana
author_sort Gurzău, Diana
collection PubMed
description Left bundle branch block is not a benign pathology, and its presence requires the identification of a pathological substrate, such as ischemic heart disease. Left bundle branch block appears to be more commonly associated with normal coronary arteries, especially in women. The objectives of our study were to describe the particularities of left bundle branch block in women compared to men with ischemic heart disease. Result: We included seventy patients with left bundle branch block and ischemic heart disease, with a mean age of 67.01 ± 8.89 years. There were no differences in the profile of risk factors, except for smoking and uric acid. The ventricular depolarization (QRS) duration was longer in men than women (136.86 ± 8.32 vs. 132.57 ± 9.19 msec; p = 0.018) and also men were observed to have larger left ventricular diameters. Left bundle branch block duration was directly associated with ventricular diameters and indirectly associated with left ventricular ejection fraction value, especially in women (R = −0.52, p = 0.0012 vs. R = −0.50, p = 0.002). In angiography, 80% of women had normal epicardial arteries compared with 65.7% of men; all these patients presented with microvascular dysfunction. Conclusion: The differences between the sexes were not so obvious in terms of the presence of risk factors; instead, there were differences in electrocardiographic, echocardiographic, and angiographic aspects. Left bundle branch block appears to be a marker of microvascular angina and systolic dysfunction, especially in women.
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spelling pubmed-81973122021-06-13 Major Left Bundle Branch Block and Coronary Heart Disease—Are There Any Differences between the Sexes? Gurzău, Diana Dădârlat-Pop, Alexandra Caloian, Bogdan Cismaru, Gabriel Comşa, Horaţiu Tomoaia, Raluca Zdrenghea, Dumitru Pop, Dana J Clin Med Article Left bundle branch block is not a benign pathology, and its presence requires the identification of a pathological substrate, such as ischemic heart disease. Left bundle branch block appears to be more commonly associated with normal coronary arteries, especially in women. The objectives of our study were to describe the particularities of left bundle branch block in women compared to men with ischemic heart disease. Result: We included seventy patients with left bundle branch block and ischemic heart disease, with a mean age of 67.01 ± 8.89 years. There were no differences in the profile of risk factors, except for smoking and uric acid. The ventricular depolarization (QRS) duration was longer in men than women (136.86 ± 8.32 vs. 132.57 ± 9.19 msec; p = 0.018) and also men were observed to have larger left ventricular diameters. Left bundle branch block duration was directly associated with ventricular diameters and indirectly associated with left ventricular ejection fraction value, especially in women (R = −0.52, p = 0.0012 vs. R = −0.50, p = 0.002). In angiography, 80% of women had normal epicardial arteries compared with 65.7% of men; all these patients presented with microvascular dysfunction. Conclusion: The differences between the sexes were not so obvious in terms of the presence of risk factors; instead, there were differences in electrocardiographic, echocardiographic, and angiographic aspects. Left bundle branch block appears to be a marker of microvascular angina and systolic dysfunction, especially in women. MDPI 2021-05-25 /pmc/articles/PMC8197312/ /pubmed/34070288 http://dx.doi.org/10.3390/jcm10112284 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gurzău, Diana
Dădârlat-Pop, Alexandra
Caloian, Bogdan
Cismaru, Gabriel
Comşa, Horaţiu
Tomoaia, Raluca
Zdrenghea, Dumitru
Pop, Dana
Major Left Bundle Branch Block and Coronary Heart Disease—Are There Any Differences between the Sexes?
title Major Left Bundle Branch Block and Coronary Heart Disease—Are There Any Differences between the Sexes?
title_full Major Left Bundle Branch Block and Coronary Heart Disease—Are There Any Differences between the Sexes?
title_fullStr Major Left Bundle Branch Block and Coronary Heart Disease—Are There Any Differences between the Sexes?
title_full_unstemmed Major Left Bundle Branch Block and Coronary Heart Disease—Are There Any Differences between the Sexes?
title_short Major Left Bundle Branch Block and Coronary Heart Disease—Are There Any Differences between the Sexes?
title_sort major left bundle branch block and coronary heart disease—are there any differences between the sexes?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197312/
https://www.ncbi.nlm.nih.gov/pubmed/34070288
http://dx.doi.org/10.3390/jcm10112284
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