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Hydrophilicity Affecting the Enzyme-Driven Degradation of Piezoelectric Poly-l-Lactide Films

Biocompatible and biodegradable poly-l-lactic acid (PLLA) processed into piezoelectric structures has good potential for use in medical applications, particularly for promoting cellular growth during electrostimulation. Significant advantages like closer contacts between cells and films are predicte...

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Autores principales: Gazvoda, Lea, Višić, Bojana, Spreitzer, Matjaž, Vukomanović, Marija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197356/
https://www.ncbi.nlm.nih.gov/pubmed/34074064
http://dx.doi.org/10.3390/polym13111719
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author Gazvoda, Lea
Višić, Bojana
Spreitzer, Matjaž
Vukomanović, Marija
author_facet Gazvoda, Lea
Višić, Bojana
Spreitzer, Matjaž
Vukomanović, Marija
author_sort Gazvoda, Lea
collection PubMed
description Biocompatible and biodegradable poly-l-lactic acid (PLLA) processed into piezoelectric structures has good potential for use in medical applications, particularly for promoting cellular growth during electrostimulation. Significant advantages like closer contacts between cells and films are predicted when their surfaces are modified to make them more hydrophilic. However, there is an open question about whether the surface modification will affect the degradation process and how the films will be changed as a result. For the first time, we demonstrate that improving the polymer surface’s wettability affects the position of enzyme-driven degradation. Although it is generally considered that proteinase K degrades only the polymer surface, we observed the enzyme’s ability to induce both surface and bulk degradation. In hydrophilic films, degradation occurs at the surface, inducing surface erosion, while for hydrophobic films, it is located inside the films, inducing bulk erosion. Accordingly, changes in the structural, morphological, mechanical, thermal and wetting properties of the film resulting from degradation vary, depending on the film’s wettability. Most importantly, the degradation is gradual, so the mechanical and piezoelectric properties are retained during the degradation.
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spelling pubmed-81973562021-06-13 Hydrophilicity Affecting the Enzyme-Driven Degradation of Piezoelectric Poly-l-Lactide Films Gazvoda, Lea Višić, Bojana Spreitzer, Matjaž Vukomanović, Marija Polymers (Basel) Article Biocompatible and biodegradable poly-l-lactic acid (PLLA) processed into piezoelectric structures has good potential for use in medical applications, particularly for promoting cellular growth during electrostimulation. Significant advantages like closer contacts between cells and films are predicted when their surfaces are modified to make them more hydrophilic. However, there is an open question about whether the surface modification will affect the degradation process and how the films will be changed as a result. For the first time, we demonstrate that improving the polymer surface’s wettability affects the position of enzyme-driven degradation. Although it is generally considered that proteinase K degrades only the polymer surface, we observed the enzyme’s ability to induce both surface and bulk degradation. In hydrophilic films, degradation occurs at the surface, inducing surface erosion, while for hydrophobic films, it is located inside the films, inducing bulk erosion. Accordingly, changes in the structural, morphological, mechanical, thermal and wetting properties of the film resulting from degradation vary, depending on the film’s wettability. Most importantly, the degradation is gradual, so the mechanical and piezoelectric properties are retained during the degradation. MDPI 2021-05-24 /pmc/articles/PMC8197356/ /pubmed/34074064 http://dx.doi.org/10.3390/polym13111719 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gazvoda, Lea
Višić, Bojana
Spreitzer, Matjaž
Vukomanović, Marija
Hydrophilicity Affecting the Enzyme-Driven Degradation of Piezoelectric Poly-l-Lactide Films
title Hydrophilicity Affecting the Enzyme-Driven Degradation of Piezoelectric Poly-l-Lactide Films
title_full Hydrophilicity Affecting the Enzyme-Driven Degradation of Piezoelectric Poly-l-Lactide Films
title_fullStr Hydrophilicity Affecting the Enzyme-Driven Degradation of Piezoelectric Poly-l-Lactide Films
title_full_unstemmed Hydrophilicity Affecting the Enzyme-Driven Degradation of Piezoelectric Poly-l-Lactide Films
title_short Hydrophilicity Affecting the Enzyme-Driven Degradation of Piezoelectric Poly-l-Lactide Films
title_sort hydrophilicity affecting the enzyme-driven degradation of piezoelectric poly-l-lactide films
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197356/
https://www.ncbi.nlm.nih.gov/pubmed/34074064
http://dx.doi.org/10.3390/polym13111719
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