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Clinical Implications of Neurological Comorbidities and Complications in ICU Patients with COVID-19

Clinical implications of neurological problems during intensive care unit (ICU) care for coronavirus disease 2019 (COVID-19) patients are unknown. This study aimed to describe the clinical implications of preexisting neurological comorbidities and new-onset neurological complications in ICU patients...

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Autores principales: Park, Jaeseok, Kwon, Yong-Shik, Kim, Hyun-Ah, Kwon, Doo-Hyuk, Hwang, Jihye, Jang, Seong-Hwa, Park, Hyungjong, Sohn, Sung-Il, Choi, Huimahn Alex, Hong, Jeong-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197394/
https://www.ncbi.nlm.nih.gov/pubmed/34070236
http://dx.doi.org/10.3390/jcm10112281
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author Park, Jaeseok
Kwon, Yong-Shik
Kim, Hyun-Ah
Kwon, Doo-Hyuk
Hwang, Jihye
Jang, Seong-Hwa
Park, Hyungjong
Sohn, Sung-Il
Choi, Huimahn Alex
Hong, Jeong-Ho
author_facet Park, Jaeseok
Kwon, Yong-Shik
Kim, Hyun-Ah
Kwon, Doo-Hyuk
Hwang, Jihye
Jang, Seong-Hwa
Park, Hyungjong
Sohn, Sung-Il
Choi, Huimahn Alex
Hong, Jeong-Ho
author_sort Park, Jaeseok
collection PubMed
description Clinical implications of neurological problems during intensive care unit (ICU) care for coronavirus disease 2019 (COVID-19) patients are unknown. This study aimed to describe the clinical implications of preexisting neurological comorbidities and new-onset neurological complications in ICU patients with COVID-19. ICU patients who were isolated and treated for COVID-19 between 19 February 2020 and 3 May 2020, from one tertiary hospital and one government-designated branch hospital were included. Clinical data including previous neurological disorders were extracted from electronic medical records. All neurological complications were evaluated by neurointensivists. Multiple logistic regression analysis was performed to investigate independent factors in ICU mortality. The median age of 52 ICU patients with COVID-19 was 73 years. Nineteen (36.5%) patients had preexisting neurological comorbidities, and new-onset neurological complications occurred in 23 (44.2%) during ICU admission. Patients with preexisting neurological comorbidities required tracheostomy more frequently and more ventilator and ICU days than those without. Patients with new-onset neurological complications experienced more medical complications and had higher ICU severity score and ICU mortality rates. New-onset neurological complications remained an independent factor for ICU mortality. Many COVID-19 patients in the ICU have preexisting neurological comorbidities, making them at a high risk of new-onset neurological complications.
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spelling pubmed-81973942021-06-13 Clinical Implications of Neurological Comorbidities and Complications in ICU Patients with COVID-19 Park, Jaeseok Kwon, Yong-Shik Kim, Hyun-Ah Kwon, Doo-Hyuk Hwang, Jihye Jang, Seong-Hwa Park, Hyungjong Sohn, Sung-Il Choi, Huimahn Alex Hong, Jeong-Ho J Clin Med Article Clinical implications of neurological problems during intensive care unit (ICU) care for coronavirus disease 2019 (COVID-19) patients are unknown. This study aimed to describe the clinical implications of preexisting neurological comorbidities and new-onset neurological complications in ICU patients with COVID-19. ICU patients who were isolated and treated for COVID-19 between 19 February 2020 and 3 May 2020, from one tertiary hospital and one government-designated branch hospital were included. Clinical data including previous neurological disorders were extracted from electronic medical records. All neurological complications were evaluated by neurointensivists. Multiple logistic regression analysis was performed to investigate independent factors in ICU mortality. The median age of 52 ICU patients with COVID-19 was 73 years. Nineteen (36.5%) patients had preexisting neurological comorbidities, and new-onset neurological complications occurred in 23 (44.2%) during ICU admission. Patients with preexisting neurological comorbidities required tracheostomy more frequently and more ventilator and ICU days than those without. Patients with new-onset neurological complications experienced more medical complications and had higher ICU severity score and ICU mortality rates. New-onset neurological complications remained an independent factor for ICU mortality. Many COVID-19 patients in the ICU have preexisting neurological comorbidities, making them at a high risk of new-onset neurological complications. MDPI 2021-05-25 /pmc/articles/PMC8197394/ /pubmed/34070236 http://dx.doi.org/10.3390/jcm10112281 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Park, Jaeseok
Kwon, Yong-Shik
Kim, Hyun-Ah
Kwon, Doo-Hyuk
Hwang, Jihye
Jang, Seong-Hwa
Park, Hyungjong
Sohn, Sung-Il
Choi, Huimahn Alex
Hong, Jeong-Ho
Clinical Implications of Neurological Comorbidities and Complications in ICU Patients with COVID-19
title Clinical Implications of Neurological Comorbidities and Complications in ICU Patients with COVID-19
title_full Clinical Implications of Neurological Comorbidities and Complications in ICU Patients with COVID-19
title_fullStr Clinical Implications of Neurological Comorbidities and Complications in ICU Patients with COVID-19
title_full_unstemmed Clinical Implications of Neurological Comorbidities and Complications in ICU Patients with COVID-19
title_short Clinical Implications of Neurological Comorbidities and Complications in ICU Patients with COVID-19
title_sort clinical implications of neurological comorbidities and complications in icu patients with covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197394/
https://www.ncbi.nlm.nih.gov/pubmed/34070236
http://dx.doi.org/10.3390/jcm10112281
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