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Preterm Delivery; Who Is at Risk?

Preterm birth (PTB) is the leading cause of perinatal morbidity and mortality. Adverse effects of preterm birth have a direct correlation with the degree of prematurity, in which infants who are born extremely preterm (24–28 weeks gestation) have the worst outcomes. We sought to determine prominent...

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Autores principales: Kluwgant, Dvora, Wainstock, Tamar, Sheiner, Eyal, Pariente, Gali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197410/
https://www.ncbi.nlm.nih.gov/pubmed/34074000
http://dx.doi.org/10.3390/jcm10112279
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author Kluwgant, Dvora
Wainstock, Tamar
Sheiner, Eyal
Pariente, Gali
author_facet Kluwgant, Dvora
Wainstock, Tamar
Sheiner, Eyal
Pariente, Gali
author_sort Kluwgant, Dvora
collection PubMed
description Preterm birth (PTB) is the leading cause of perinatal morbidity and mortality. Adverse effects of preterm birth have a direct correlation with the degree of prematurity, in which infants who are born extremely preterm (24–28 weeks gestation) have the worst outcomes. We sought to determine prominent risk factors for extreme PTB and whether these factors varied between various sub-populations with known risk factors such as previous PTB and multiple gestations. A population-based retrospective cohort study was conducted. Risk factors were examined in cases of extreme PTB in the general population, as well as various sub-groups: singleton and multiple gestations, women with a previous PTB, and women with indicated or induced PTB. A total of 334,415 deliveries were included, of which 1155 (0.35%) were in the extreme PTB group. Placenta previa (OR = 5.8, 95%CI 4.14–8.34, p < 0.001), multiple gestations (OR = 7.7, 95% CI 6.58–9.04, p < 0.001), and placental abruption (OR = 20.6, 95%CI 17.00–24.96, p < 0.001) were the strongest risk factors for extreme PTB. In sub-populations (multiple gestations, women with previous PTB and indicated PTBs), risk factors included placental abruption and previa, lack of prenatal care, and recurrent pregnancy loss. Singleton extreme PTB risk factors included nulliparity, lack of prenatal care, and placental abruption. Placental abruption was the strongest risk factor for extreme preterm birth in all groups, and risk factors did not differ significantly between sub-populations.
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spelling pubmed-81974102021-06-13 Preterm Delivery; Who Is at Risk? Kluwgant, Dvora Wainstock, Tamar Sheiner, Eyal Pariente, Gali J Clin Med Article Preterm birth (PTB) is the leading cause of perinatal morbidity and mortality. Adverse effects of preterm birth have a direct correlation with the degree of prematurity, in which infants who are born extremely preterm (24–28 weeks gestation) have the worst outcomes. We sought to determine prominent risk factors for extreme PTB and whether these factors varied between various sub-populations with known risk factors such as previous PTB and multiple gestations. A population-based retrospective cohort study was conducted. Risk factors were examined in cases of extreme PTB in the general population, as well as various sub-groups: singleton and multiple gestations, women with a previous PTB, and women with indicated or induced PTB. A total of 334,415 deliveries were included, of which 1155 (0.35%) were in the extreme PTB group. Placenta previa (OR = 5.8, 95%CI 4.14–8.34, p < 0.001), multiple gestations (OR = 7.7, 95% CI 6.58–9.04, p < 0.001), and placental abruption (OR = 20.6, 95%CI 17.00–24.96, p < 0.001) were the strongest risk factors for extreme PTB. In sub-populations (multiple gestations, women with previous PTB and indicated PTBs), risk factors included placental abruption and previa, lack of prenatal care, and recurrent pregnancy loss. Singleton extreme PTB risk factors included nulliparity, lack of prenatal care, and placental abruption. Placental abruption was the strongest risk factor for extreme preterm birth in all groups, and risk factors did not differ significantly between sub-populations. MDPI 2021-05-24 /pmc/articles/PMC8197410/ /pubmed/34074000 http://dx.doi.org/10.3390/jcm10112279 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kluwgant, Dvora
Wainstock, Tamar
Sheiner, Eyal
Pariente, Gali
Preterm Delivery; Who Is at Risk?
title Preterm Delivery; Who Is at Risk?
title_full Preterm Delivery; Who Is at Risk?
title_fullStr Preterm Delivery; Who Is at Risk?
title_full_unstemmed Preterm Delivery; Who Is at Risk?
title_short Preterm Delivery; Who Is at Risk?
title_sort preterm delivery; who is at risk?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197410/
https://www.ncbi.nlm.nih.gov/pubmed/34074000
http://dx.doi.org/10.3390/jcm10112279
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