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Optical Coherence Tomography Angiography Metrics Monitor Severity Progression of Diabetic Retinopathy—3-Year Longitudinal Study

To examine retinal vessel closure metrics and neurodegenerative changes occurring in the initial stages of nonproliferative diabetic retinopathy (NPDR) and severity progression in a three-year period. Methods: Three-year prospective longitudinal observational cohort of individuals with type 2 diabet...

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Autores principales: Marques, Inês P., Kubach, Sophie, Santos, Torcato, Mendes, Luís, Madeira, Maria H., de Sisternes, Luis, Tavares, Diana, Santos, Ana Rita, Lewis, Warren, Lobo, Conceição, Durbin, Mary K., Cunha-Vaz, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197493/
https://www.ncbi.nlm.nih.gov/pubmed/34070479
http://dx.doi.org/10.3390/jcm10112296
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author Marques, Inês P.
Kubach, Sophie
Santos, Torcato
Mendes, Luís
Madeira, Maria H.
de Sisternes, Luis
Tavares, Diana
Santos, Ana Rita
Lewis, Warren
Lobo, Conceição
Durbin, Mary K.
Cunha-Vaz, José
author_facet Marques, Inês P.
Kubach, Sophie
Santos, Torcato
Mendes, Luís
Madeira, Maria H.
de Sisternes, Luis
Tavares, Diana
Santos, Ana Rita
Lewis, Warren
Lobo, Conceição
Durbin, Mary K.
Cunha-Vaz, José
author_sort Marques, Inês P.
collection PubMed
description To examine retinal vessel closure metrics and neurodegenerative changes occurring in the initial stages of nonproliferative diabetic retinopathy (NPDR) and severity progression in a three-year period. Methods: Three-year prospective longitudinal observational cohort of individuals with type 2 diabetes (T2D), one eye per person, using spectral domain-optical coherence tomography (SD-OCT) and OCT-Angiography (OCTA). Eyes were examined four times with one-year intervals. OCTA vessel density maps of the retina were used to quantify vessel closure. Thickness of the ganglion cell + inner plexiform layer (GCL + IPL) was examined to identify retinal neurodegenerative changes. Diabetic retinopathy ETDRS classification was performed using the seven-field ETDRS protocol. Results: A total of 78 eyes/patients, aged 52 to 80 years, with T2D and ETDRS grades from 10 to 47 were followed for 3 years with annual examinations. A progressive increase in retinal vessel closure was observed. Vessel density (VD) showed higher decreases with retinopathy worsening demonstrated by step-changes in ETDRS severity scale (p < 0.001). No clear correlation was observed between neurodegenerative changes and retinopathy progression. Conclusions: Retinal vessel closure in NPDR correlates with DR severity progression. Our findings provide supporting evidence that OCTA metrics of vessel closure may be used as a surrogate for DR severity progression.
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spelling pubmed-81974932021-06-13 Optical Coherence Tomography Angiography Metrics Monitor Severity Progression of Diabetic Retinopathy—3-Year Longitudinal Study Marques, Inês P. Kubach, Sophie Santos, Torcato Mendes, Luís Madeira, Maria H. de Sisternes, Luis Tavares, Diana Santos, Ana Rita Lewis, Warren Lobo, Conceição Durbin, Mary K. Cunha-Vaz, José J Clin Med Article To examine retinal vessel closure metrics and neurodegenerative changes occurring in the initial stages of nonproliferative diabetic retinopathy (NPDR) and severity progression in a three-year period. Methods: Three-year prospective longitudinal observational cohort of individuals with type 2 diabetes (T2D), one eye per person, using spectral domain-optical coherence tomography (SD-OCT) and OCT-Angiography (OCTA). Eyes were examined four times with one-year intervals. OCTA vessel density maps of the retina were used to quantify vessel closure. Thickness of the ganglion cell + inner plexiform layer (GCL + IPL) was examined to identify retinal neurodegenerative changes. Diabetic retinopathy ETDRS classification was performed using the seven-field ETDRS protocol. Results: A total of 78 eyes/patients, aged 52 to 80 years, with T2D and ETDRS grades from 10 to 47 were followed for 3 years with annual examinations. A progressive increase in retinal vessel closure was observed. Vessel density (VD) showed higher decreases with retinopathy worsening demonstrated by step-changes in ETDRS severity scale (p < 0.001). No clear correlation was observed between neurodegenerative changes and retinopathy progression. Conclusions: Retinal vessel closure in NPDR correlates with DR severity progression. Our findings provide supporting evidence that OCTA metrics of vessel closure may be used as a surrogate for DR severity progression. MDPI 2021-05-25 /pmc/articles/PMC8197493/ /pubmed/34070479 http://dx.doi.org/10.3390/jcm10112296 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Marques, Inês P.
Kubach, Sophie
Santos, Torcato
Mendes, Luís
Madeira, Maria H.
de Sisternes, Luis
Tavares, Diana
Santos, Ana Rita
Lewis, Warren
Lobo, Conceição
Durbin, Mary K.
Cunha-Vaz, José
Optical Coherence Tomography Angiography Metrics Monitor Severity Progression of Diabetic Retinopathy—3-Year Longitudinal Study
title Optical Coherence Tomography Angiography Metrics Monitor Severity Progression of Diabetic Retinopathy—3-Year Longitudinal Study
title_full Optical Coherence Tomography Angiography Metrics Monitor Severity Progression of Diabetic Retinopathy—3-Year Longitudinal Study
title_fullStr Optical Coherence Tomography Angiography Metrics Monitor Severity Progression of Diabetic Retinopathy—3-Year Longitudinal Study
title_full_unstemmed Optical Coherence Tomography Angiography Metrics Monitor Severity Progression of Diabetic Retinopathy—3-Year Longitudinal Study
title_short Optical Coherence Tomography Angiography Metrics Monitor Severity Progression of Diabetic Retinopathy—3-Year Longitudinal Study
title_sort optical coherence tomography angiography metrics monitor severity progression of diabetic retinopathy—3-year longitudinal study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197493/
https://www.ncbi.nlm.nih.gov/pubmed/34070479
http://dx.doi.org/10.3390/jcm10112296
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