Cargando…

Sophisticated Conversations between Chromatin and Chromatin Remodelers, and Dissonances in Cancer

The establishment and maintenance of genome packaging into chromatin contribute to define specific cellular identity and function. Dynamic regulation of chromatin organization and nucleosome positioning are critical to all DNA transactions—in particular, the regulation of gene expression—and involve...

Descripción completa

Detalles Bibliográficos
Autor principal: Clapier, Cedric R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197500/
https://www.ncbi.nlm.nih.gov/pubmed/34070411
http://dx.doi.org/10.3390/ijms22115578
_version_ 1783706931636994048
author Clapier, Cedric R.
author_facet Clapier, Cedric R.
author_sort Clapier, Cedric R.
collection PubMed
description The establishment and maintenance of genome packaging into chromatin contribute to define specific cellular identity and function. Dynamic regulation of chromatin organization and nucleosome positioning are critical to all DNA transactions—in particular, the regulation of gene expression—and involve the cooperative action of sequence-specific DNA-binding factors, histone modifying enzymes, and remodelers. Remodelers are molecular machines that generate various chromatin landscapes, adjust nucleosome positioning, and alter DNA accessibility by using ATP binding and hydrolysis to perform DNA translocation, which is highly regulated through sophisticated structural and functional conversations with nucleosomes. In this review, I first present the functional and structural diversity of remodelers, while emphasizing the basic mechanism of DNA translocation, the common regulatory aspects, and the hand-in-hand progressive increase in complexity of the regulatory conversations between remodelers and nucleosomes that accompanies the increase in challenges of remodeling processes. Next, I examine how, through nucleosome positioning, remodelers guide the regulation of gene expression. Finally, I explore various aspects of how alterations/mutations in remodelers introduce dissonance into the conversations between remodelers and nucleosomes, modify chromatin organization, and contribute to oncogenesis.
format Online
Article
Text
id pubmed-8197500
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81975002021-06-13 Sophisticated Conversations between Chromatin and Chromatin Remodelers, and Dissonances in Cancer Clapier, Cedric R. Int J Mol Sci Review The establishment and maintenance of genome packaging into chromatin contribute to define specific cellular identity and function. Dynamic regulation of chromatin organization and nucleosome positioning are critical to all DNA transactions—in particular, the regulation of gene expression—and involve the cooperative action of sequence-specific DNA-binding factors, histone modifying enzymes, and remodelers. Remodelers are molecular machines that generate various chromatin landscapes, adjust nucleosome positioning, and alter DNA accessibility by using ATP binding and hydrolysis to perform DNA translocation, which is highly regulated through sophisticated structural and functional conversations with nucleosomes. In this review, I first present the functional and structural diversity of remodelers, while emphasizing the basic mechanism of DNA translocation, the common regulatory aspects, and the hand-in-hand progressive increase in complexity of the regulatory conversations between remodelers and nucleosomes that accompanies the increase in challenges of remodeling processes. Next, I examine how, through nucleosome positioning, remodelers guide the regulation of gene expression. Finally, I explore various aspects of how alterations/mutations in remodelers introduce dissonance into the conversations between remodelers and nucleosomes, modify chromatin organization, and contribute to oncogenesis. MDPI 2021-05-25 /pmc/articles/PMC8197500/ /pubmed/34070411 http://dx.doi.org/10.3390/ijms22115578 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Clapier, Cedric R.
Sophisticated Conversations between Chromatin and Chromatin Remodelers, and Dissonances in Cancer
title Sophisticated Conversations between Chromatin and Chromatin Remodelers, and Dissonances in Cancer
title_full Sophisticated Conversations between Chromatin and Chromatin Remodelers, and Dissonances in Cancer
title_fullStr Sophisticated Conversations between Chromatin and Chromatin Remodelers, and Dissonances in Cancer
title_full_unstemmed Sophisticated Conversations between Chromatin and Chromatin Remodelers, and Dissonances in Cancer
title_short Sophisticated Conversations between Chromatin and Chromatin Remodelers, and Dissonances in Cancer
title_sort sophisticated conversations between chromatin and chromatin remodelers, and dissonances in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197500/
https://www.ncbi.nlm.nih.gov/pubmed/34070411
http://dx.doi.org/10.3390/ijms22115578
work_keys_str_mv AT clapiercedricr sophisticatedconversationsbetweenchromatinandchromatinremodelersanddissonancesincancer