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Additive Benefits of Radium-223 Dichloride and Bortezomib Combination in a Systemic Multiple Myeloma Mouse Model
Osteolytic bone disease is a hallmark of multiple myeloma (MM) mediated by MM cell proliferation, increased osteoclast activity, and suppressed osteoblast function. The proteasome inhibitor bortezomib targets MM cells and improves bone health in MM patients. Radium-223 dichloride (radium-223), the f...
Autores principales: | Suominen, Mari I., Mäki-Jouppila, Jenni, Huhtinen, Anna, Sjöholm, Birgitta, Rissanen, Jukka P., Luostarinen, Anniina, Fagerlund, Katja M., Alhoniemi, Esa, Siemeister, Gerhard, Mumberg, Dominik, Käkönen, Sanna-Maria, Scholz, Arne |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197539/ https://www.ncbi.nlm.nih.gov/pubmed/34070363 http://dx.doi.org/10.3390/ijms22115570 |
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