Oncological Frontiers in the Treatment of Malignant Pleural Mesothelioma

Malignant pleural mesothelioma (MPM) is a rare malignancy characterized by very poor prognosis and lack of treatment options. Immunotherapy has rapidly emerged as an effective tool for MPM, particularly for tumors of non-epithelioid histology. At the same time, comprehensive genomic sequencing may o...

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Autores principales: Vita, Emanuele, Stefani, Alessio, Di Salvatore, Mariantonietta, Chiappetta, Marco, Lococo, Filippo, Margaritora, Stefano, Tortora, Giampaolo, Bria, Emilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197557/
https://www.ncbi.nlm.nih.gov/pubmed/34070352
http://dx.doi.org/10.3390/jcm10112290
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author Vita, Emanuele
Stefani, Alessio
Di Salvatore, Mariantonietta
Chiappetta, Marco
Lococo, Filippo
Margaritora, Stefano
Tortora, Giampaolo
Bria, Emilio
author_facet Vita, Emanuele
Stefani, Alessio
Di Salvatore, Mariantonietta
Chiappetta, Marco
Lococo, Filippo
Margaritora, Stefano
Tortora, Giampaolo
Bria, Emilio
author_sort Vita, Emanuele
collection PubMed
description Malignant pleural mesothelioma (MPM) is a rare malignancy characterized by very poor prognosis and lack of treatment options. Immunotherapy has rapidly emerged as an effective tool for MPM, particularly for tumors of non-epithelioid histology. At the same time, comprehensive genomic sequencing may open the way to new-generation targeted-drugs able to hit specific MPM molecular vulnerabilities. These innovations will possibly enrich, but also dramatically complicate, the elucidation of treatment algorithms. Multidisciplinary integration is urgently needed.
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spelling pubmed-81975572021-06-13 Oncological Frontiers in the Treatment of Malignant Pleural Mesothelioma Vita, Emanuele Stefani, Alessio Di Salvatore, Mariantonietta Chiappetta, Marco Lococo, Filippo Margaritora, Stefano Tortora, Giampaolo Bria, Emilio J Clin Med Review Malignant pleural mesothelioma (MPM) is a rare malignancy characterized by very poor prognosis and lack of treatment options. Immunotherapy has rapidly emerged as an effective tool for MPM, particularly for tumors of non-epithelioid histology. At the same time, comprehensive genomic sequencing may open the way to new-generation targeted-drugs able to hit specific MPM molecular vulnerabilities. These innovations will possibly enrich, but also dramatically complicate, the elucidation of treatment algorithms. Multidisciplinary integration is urgently needed. MDPI 2021-05-25 /pmc/articles/PMC8197557/ /pubmed/34070352 http://dx.doi.org/10.3390/jcm10112290 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vita, Emanuele
Stefani, Alessio
Di Salvatore, Mariantonietta
Chiappetta, Marco
Lococo, Filippo
Margaritora, Stefano
Tortora, Giampaolo
Bria, Emilio
Oncological Frontiers in the Treatment of Malignant Pleural Mesothelioma
title Oncological Frontiers in the Treatment of Malignant Pleural Mesothelioma
title_full Oncological Frontiers in the Treatment of Malignant Pleural Mesothelioma
title_fullStr Oncological Frontiers in the Treatment of Malignant Pleural Mesothelioma
title_full_unstemmed Oncological Frontiers in the Treatment of Malignant Pleural Mesothelioma
title_short Oncological Frontiers in the Treatment of Malignant Pleural Mesothelioma
title_sort oncological frontiers in the treatment of malignant pleural mesothelioma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197557/
https://www.ncbi.nlm.nih.gov/pubmed/34070352
http://dx.doi.org/10.3390/jcm10112290
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