Periventricular White Matter Hyperintensity in Males is Associated with Post-Stroke Depression Onset at 3 Months

OBJECTIVE: This study aimed to explore the correlation between white matter hyperintensity (WMH) and post-stroke depression (PSD) at 3 months, and to further investigate sex differences in the pathogenesis of PSD. METHODS: A total of 238 consecutive patients with acute cerebral infarction were recru...

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Autores principales: Tu, Xuan-qiang, Lai, Ze-hua, Zhang, Yu, Ding, Kai-qi, Ma, Fei-yue, Yang, Guo-Yuan, He, Ji-rong, Zeng, Li-li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197583/
https://www.ncbi.nlm.nih.gov/pubmed/34135586
http://dx.doi.org/10.2147/NDT.S311207
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author Tu, Xuan-qiang
Lai, Ze-hua
Zhang, Yu
Ding, Kai-qi
Ma, Fei-yue
Yang, Guo-Yuan
He, Ji-rong
Zeng, Li-li
author_facet Tu, Xuan-qiang
Lai, Ze-hua
Zhang, Yu
Ding, Kai-qi
Ma, Fei-yue
Yang, Guo-Yuan
He, Ji-rong
Zeng, Li-li
author_sort Tu, Xuan-qiang
collection PubMed
description OBJECTIVE: This study aimed to explore the correlation between white matter hyperintensity (WMH) and post-stroke depression (PSD) at 3 months, and to further investigate sex differences in the pathogenesis of PSD. METHODS: A total of 238 consecutive patients with acute cerebral infarction were recruited. PSD was assessed at 2 weeks and at 3 months after stroke onset. All stroke cases were divided into four subgroups according to the diagnosis of depression at two time nodes: continuous depression; depression remission; late-onset PSD; and continuous non-depression. The Fazekas and Scheltens visual rating scales were adopted to assess WMH. RESULTS: Logistic regression revealed that the presence of periventricular white matter hyperintensity (PVWMH) at baseline in male patients was an independent risk factor for PSD at 3 months. Further subgroup analysis revealed that PVWMH was associated with late-onset PSD in males, but not with continuous depression 3 months after stroke. Male acute stroke patients with PVWMH at baseline were more likely to develop PSD at 3 months, especially late-onset PSD. CONCLUSION: Our data suggest that sex differences may influence the pathogenesis of PSD.
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spelling pubmed-81975832021-06-15 Periventricular White Matter Hyperintensity in Males is Associated with Post-Stroke Depression Onset at 3 Months Tu, Xuan-qiang Lai, Ze-hua Zhang, Yu Ding, Kai-qi Ma, Fei-yue Yang, Guo-Yuan He, Ji-rong Zeng, Li-li Neuropsychiatr Dis Treat Original Research OBJECTIVE: This study aimed to explore the correlation between white matter hyperintensity (WMH) and post-stroke depression (PSD) at 3 months, and to further investigate sex differences in the pathogenesis of PSD. METHODS: A total of 238 consecutive patients with acute cerebral infarction were recruited. PSD was assessed at 2 weeks and at 3 months after stroke onset. All stroke cases were divided into four subgroups according to the diagnosis of depression at two time nodes: continuous depression; depression remission; late-onset PSD; and continuous non-depression. The Fazekas and Scheltens visual rating scales were adopted to assess WMH. RESULTS: Logistic regression revealed that the presence of periventricular white matter hyperintensity (PVWMH) at baseline in male patients was an independent risk factor for PSD at 3 months. Further subgroup analysis revealed that PVWMH was associated with late-onset PSD in males, but not with continuous depression 3 months after stroke. Male acute stroke patients with PVWMH at baseline were more likely to develop PSD at 3 months, especially late-onset PSD. CONCLUSION: Our data suggest that sex differences may influence the pathogenesis of PSD. Dove 2021-06-08 /pmc/articles/PMC8197583/ /pubmed/34135586 http://dx.doi.org/10.2147/NDT.S311207 Text en © 2021 Tu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Tu, Xuan-qiang
Lai, Ze-hua
Zhang, Yu
Ding, Kai-qi
Ma, Fei-yue
Yang, Guo-Yuan
He, Ji-rong
Zeng, Li-li
Periventricular White Matter Hyperintensity in Males is Associated with Post-Stroke Depression Onset at 3 Months
title Periventricular White Matter Hyperintensity in Males is Associated with Post-Stroke Depression Onset at 3 Months
title_full Periventricular White Matter Hyperintensity in Males is Associated with Post-Stroke Depression Onset at 3 Months
title_fullStr Periventricular White Matter Hyperintensity in Males is Associated with Post-Stroke Depression Onset at 3 Months
title_full_unstemmed Periventricular White Matter Hyperintensity in Males is Associated with Post-Stroke Depression Onset at 3 Months
title_short Periventricular White Matter Hyperintensity in Males is Associated with Post-Stroke Depression Onset at 3 Months
title_sort periventricular white matter hyperintensity in males is associated with post-stroke depression onset at 3 months
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197583/
https://www.ncbi.nlm.nih.gov/pubmed/34135586
http://dx.doi.org/10.2147/NDT.S311207
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