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Experimental phantom evaluation to identify robust positron emission tomography (PET) radiomic features
BACKGROUND: Radiomics analysis usually involves, especially in multicenter and large hospital studies, different imaging protocols for acquisition, reconstruction, and processing of data. Differences in protocols can lead to differences in the quantification of the biomarker distribution, leading to...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197692/ https://www.ncbi.nlm.nih.gov/pubmed/34117929 http://dx.doi.org/10.1186/s40658-021-00390-7 |
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author | Carles, Montserrat Fechter, Tobias Martí-Bonmatí, Luis Baltas, Dimos Mix, Michael |
author_facet | Carles, Montserrat Fechter, Tobias Martí-Bonmatí, Luis Baltas, Dimos Mix, Michael |
author_sort | Carles, Montserrat |
collection | PubMed |
description | BACKGROUND: Radiomics analysis usually involves, especially in multicenter and large hospital studies, different imaging protocols for acquisition, reconstruction, and processing of data. Differences in protocols can lead to differences in the quantification of the biomarker distribution, leading to radiomic feature variability. The aim of our study was to identify those radiomic features robust to the different degrading factors in positron emission tomography (PET) studies. We proposed the use of the standardized measurements of the European Association Research Ltd. (EARL) accreditation to retrospectively identify the radiomic features having low variability to the different systems and reconstruction protocols. In addition, we presented a reproducible procedure to identify PET radiomic features robust to PET/CT imaging metal artifacts. In 27 heterogeneous homemade phantoms for which ground truth was accurately defined by CT segmentation, we evaluated the segmentation accuracy and radiomic feature reliability given by the contrast-oriented algorithm (COA) and the 40% threshold PET segmentation. In the comparison of two data sets, robustness was defined by Wilcoxon rank tests, bias was quantified by Bland–Altman (BA) plot analysis, and strong correlations were identified by Spearman correlation test (r > 0.8 and p satisfied multiple test Bonferroni correction). RESULTS: Forty-eight radiomic features were robust to system, 22 to resolution, 102 to metal artifacts, and 42 to different PET segmentation tools. Overall, only 4 radiomic features were simultaneously robust to all degrading factors. Although both segmentation approaches significantly underestimated the volume with respect to the ground truth, with relative deviations of −62 ± 36% for COA and −50 ± 44% for 40%, radiomic features derived from the ground truth were strongly correlated and/or robust to 98 radiomic features derived from COA and to 102 from 40%. CONCLUSION: In multicenter studies, we recommend the analysis of EARL accreditation measurements in order to retrospectively identify the robust PET radiomic features. Furthermore, 4 radiomic features (area under the curve of the cumulative SUV volume histogram, skewness, kurtosis, and gray-level variance derived from GLRLM after application of an equal probability quantization algorithm on the voxels within lesion) were robust to all degrading factors. In addition, the feasibility of 40% and COA segmentations for their use in radiomics analysis has been demonstrated. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40658-021-00390-7. |
format | Online Article Text |
id | pubmed-8197692 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-81976922021-06-28 Experimental phantom evaluation to identify robust positron emission tomography (PET) radiomic features Carles, Montserrat Fechter, Tobias Martí-Bonmatí, Luis Baltas, Dimos Mix, Michael EJNMMI Phys Original Research BACKGROUND: Radiomics analysis usually involves, especially in multicenter and large hospital studies, different imaging protocols for acquisition, reconstruction, and processing of data. Differences in protocols can lead to differences in the quantification of the biomarker distribution, leading to radiomic feature variability. The aim of our study was to identify those radiomic features robust to the different degrading factors in positron emission tomography (PET) studies. We proposed the use of the standardized measurements of the European Association Research Ltd. (EARL) accreditation to retrospectively identify the radiomic features having low variability to the different systems and reconstruction protocols. In addition, we presented a reproducible procedure to identify PET radiomic features robust to PET/CT imaging metal artifacts. In 27 heterogeneous homemade phantoms for which ground truth was accurately defined by CT segmentation, we evaluated the segmentation accuracy and radiomic feature reliability given by the contrast-oriented algorithm (COA) and the 40% threshold PET segmentation. In the comparison of two data sets, robustness was defined by Wilcoxon rank tests, bias was quantified by Bland–Altman (BA) plot analysis, and strong correlations were identified by Spearman correlation test (r > 0.8 and p satisfied multiple test Bonferroni correction). RESULTS: Forty-eight radiomic features were robust to system, 22 to resolution, 102 to metal artifacts, and 42 to different PET segmentation tools. Overall, only 4 radiomic features were simultaneously robust to all degrading factors. Although both segmentation approaches significantly underestimated the volume with respect to the ground truth, with relative deviations of −62 ± 36% for COA and −50 ± 44% for 40%, radiomic features derived from the ground truth were strongly correlated and/or robust to 98 radiomic features derived from COA and to 102 from 40%. CONCLUSION: In multicenter studies, we recommend the analysis of EARL accreditation measurements in order to retrospectively identify the robust PET radiomic features. Furthermore, 4 radiomic features (area under the curve of the cumulative SUV volume histogram, skewness, kurtosis, and gray-level variance derived from GLRLM after application of an equal probability quantization algorithm on the voxels within lesion) were robust to all degrading factors. In addition, the feasibility of 40% and COA segmentations for their use in radiomics analysis has been demonstrated. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40658-021-00390-7. Springer International Publishing 2021-06-12 /pmc/articles/PMC8197692/ /pubmed/34117929 http://dx.doi.org/10.1186/s40658-021-00390-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Original Research Carles, Montserrat Fechter, Tobias Martí-Bonmatí, Luis Baltas, Dimos Mix, Michael Experimental phantom evaluation to identify robust positron emission tomography (PET) radiomic features |
title | Experimental phantom evaluation to identify robust positron emission tomography (PET) radiomic features |
title_full | Experimental phantom evaluation to identify robust positron emission tomography (PET) radiomic features |
title_fullStr | Experimental phantom evaluation to identify robust positron emission tomography (PET) radiomic features |
title_full_unstemmed | Experimental phantom evaluation to identify robust positron emission tomography (PET) radiomic features |
title_short | Experimental phantom evaluation to identify robust positron emission tomography (PET) radiomic features |
title_sort | experimental phantom evaluation to identify robust positron emission tomography (pet) radiomic features |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197692/ https://www.ncbi.nlm.nih.gov/pubmed/34117929 http://dx.doi.org/10.1186/s40658-021-00390-7 |
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