G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production

Glioma is the most common primary tumor in the central nervous system. However, the development of glioma and effective therapeutic strategies remain elusive. Here, we identify GPR17 as a potential target to treat glioma. Data mining with human LGG and GBM samples reveals that GPR17 is negatively co...

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Detalles Bibliográficos
Autores principales: Liu, Huiqing, Xing, Rui, Ou, Zhimin, Zhao, Junying, Hong, Guolin, Zhao, Tong-Jin, Han, Ying, Chen, Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197764/
https://www.ncbi.nlm.nih.gov/pubmed/34120140
http://dx.doi.org/10.1038/s41419-021-03897-0

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