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Regulation of ClC-2 Chloride Channel Proteostasis by Molecular Chaperones: Correction of Leukodystrophy-Associated Defect

The ClC-2 channel plays a critical role in maintaining ion homeostasis in the brain and the testis. Loss-of-function mutations in the ClC-2-encoding human CLCN2 gene are linked to the white matter disease leukodystrophy. Clcn2-deficient mice display neuronal myelin vacuolation and testicular degener...

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Detalles Bibliográficos
Autores principales:	Fu, Ssu-Ju, Hu, Meng-Chun, Hsiao, Cheng-Tsung, Cheng, An-Ting, Chen, Tsung-Yu, Jeng, Chung-Jiuan, Tang, Chih-Yung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197790/ https://www.ncbi.nlm.nih.gov/pubmed/34070744 http://dx.doi.org/10.3390/ijms22115859

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