Cargando…

IgA Vasculitis and IgA Nephropathy: Same Disease?

Many authors suggested that IgA Vasculitis (IgAV) and IgA Nephropathy (IgAN) would be two clinical manifestations of the same disease; in particular, that IgAV would be the systemic form of the IgAN. A limited number of studies have included sufficient children or adults with IgAN or IgAV (with or w...

Descripción completa

Detalles Bibliográficos
Autor principal: Pillebout, Evangeline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197792/
https://www.ncbi.nlm.nih.gov/pubmed/34070665
http://dx.doi.org/10.3390/jcm10112310
_version_ 1783706986016145408
author Pillebout, Evangeline
author_facet Pillebout, Evangeline
author_sort Pillebout, Evangeline
collection PubMed
description Many authors suggested that IgA Vasculitis (IgAV) and IgA Nephropathy (IgAN) would be two clinical manifestations of the same disease; in particular, that IgAV would be the systemic form of the IgAN. A limited number of studies have included sufficient children or adults with IgAN or IgAV (with or without nephropathy) and followed long enough to conclude on differences or similarities in terms of clinical, biological or histological presentation, physiopathology, genetics or prognosis. All therapeutic trials available on IgAN excluded patients with vasculitis. IgAV and IgAN could represent different extremities of a continuous spectrum of the same disease. Due to skin rash, patients with IgAV are diagnosed precociously. Conversely, because of the absence of any clinical signs, a renal biopsy is practiced for patients with an IgAN to confirm nephropathy at any time of the evolution of the disease, which could explain the frequent chronic lesions at diagnosis. Nevertheless, the question that remains unsolved is why do patients with IgAN not have skin lesions and some patients with IgAV not have nephropathy? Larger clinical studies are needed, including both diseases, with a common histological classification, and stratified on age and genetic background to assess renal prognosis and therapeutic strategies.
format Online
Article
Text
id pubmed-8197792
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81977922021-06-14 IgA Vasculitis and IgA Nephropathy: Same Disease? Pillebout, Evangeline J Clin Med Review Many authors suggested that IgA Vasculitis (IgAV) and IgA Nephropathy (IgAN) would be two clinical manifestations of the same disease; in particular, that IgAV would be the systemic form of the IgAN. A limited number of studies have included sufficient children or adults with IgAN or IgAV (with or without nephropathy) and followed long enough to conclude on differences or similarities in terms of clinical, biological or histological presentation, physiopathology, genetics or prognosis. All therapeutic trials available on IgAN excluded patients with vasculitis. IgAV and IgAN could represent different extremities of a continuous spectrum of the same disease. Due to skin rash, patients with IgAV are diagnosed precociously. Conversely, because of the absence of any clinical signs, a renal biopsy is practiced for patients with an IgAN to confirm nephropathy at any time of the evolution of the disease, which could explain the frequent chronic lesions at diagnosis. Nevertheless, the question that remains unsolved is why do patients with IgAN not have skin lesions and some patients with IgAV not have nephropathy? Larger clinical studies are needed, including both diseases, with a common histological classification, and stratified on age and genetic background to assess renal prognosis and therapeutic strategies. MDPI 2021-05-25 /pmc/articles/PMC8197792/ /pubmed/34070665 http://dx.doi.org/10.3390/jcm10112310 Text en © 2021 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pillebout, Evangeline
IgA Vasculitis and IgA Nephropathy: Same Disease?
title IgA Vasculitis and IgA Nephropathy: Same Disease?
title_full IgA Vasculitis and IgA Nephropathy: Same Disease?
title_fullStr IgA Vasculitis and IgA Nephropathy: Same Disease?
title_full_unstemmed IgA Vasculitis and IgA Nephropathy: Same Disease?
title_short IgA Vasculitis and IgA Nephropathy: Same Disease?
title_sort iga vasculitis and iga nephropathy: same disease?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197792/
https://www.ncbi.nlm.nih.gov/pubmed/34070665
http://dx.doi.org/10.3390/jcm10112310
work_keys_str_mv AT pilleboutevangeline igavasculitisandiganephropathysamedisease