Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma

Sulforaphane (SFN) is a natural glucosinolate found in cruciferous vegetables that acts as a chemopreventive agent, but its mechanism of action is not clear. Due to antioxidative mechanisms being thought central in preventing cancer progression, SFN could play a role in oxidative processes. Since re...

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Detalles Bibliográficos
Autores principales: Xie, Hui, Chun, Felix K.-H., Rutz, Jochen, Blaheta, Roman A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197880/
https://www.ncbi.nlm.nih.gov/pubmed/34073079
http://dx.doi.org/10.3390/ijms22115938
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author Xie, Hui
Chun, Felix K.-H.
Rutz, Jochen
Blaheta, Roman A.
author_facet Xie, Hui
Chun, Felix K.-H.
Rutz, Jochen
Blaheta, Roman A.
author_sort Xie, Hui
collection PubMed
description Sulforaphane (SFN) is a natural glucosinolate found in cruciferous vegetables that acts as a chemopreventive agent, but its mechanism of action is not clear. Due to antioxidative mechanisms being thought central in preventing cancer progression, SFN could play a role in oxidative processes. Since redox imbalance with increased levels of reactive oxygen species (ROS) is involved in the initiation and progression of bladder cancer, this mechanism might be involved when chemoresistance occurs. This review summarizes current understanding regarding the influence of SFN on ROS and ROS-related pathways and appraises a possible role of SFN in bladder cancer treatment.
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spelling pubmed-81978802021-06-14 Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma Xie, Hui Chun, Felix K.-H. Rutz, Jochen Blaheta, Roman A. Int J Mol Sci Review Sulforaphane (SFN) is a natural glucosinolate found in cruciferous vegetables that acts as a chemopreventive agent, but its mechanism of action is not clear. Due to antioxidative mechanisms being thought central in preventing cancer progression, SFN could play a role in oxidative processes. Since redox imbalance with increased levels of reactive oxygen species (ROS) is involved in the initiation and progression of bladder cancer, this mechanism might be involved when chemoresistance occurs. This review summarizes current understanding regarding the influence of SFN on ROS and ROS-related pathways and appraises a possible role of SFN in bladder cancer treatment. MDPI 2021-05-31 /pmc/articles/PMC8197880/ /pubmed/34073079 http://dx.doi.org/10.3390/ijms22115938 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Xie, Hui
Chun, Felix K.-H.
Rutz, Jochen
Blaheta, Roman A.
Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
title Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
title_full Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
title_fullStr Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
title_full_unstemmed Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
title_short Sulforaphane Impact on Reactive Oxygen Species (ROS) in Bladder Carcinoma
title_sort sulforaphane impact on reactive oxygen species (ros) in bladder carcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197880/
https://www.ncbi.nlm.nih.gov/pubmed/34073079
http://dx.doi.org/10.3390/ijms22115938
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AT rutzjochen sulforaphaneimpactonreactiveoxygenspeciesrosinbladdercarcinoma
AT blahetaromana sulforaphaneimpactonreactiveoxygenspeciesrosinbladdercarcinoma

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