Cargando…

OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses

Background: optical coherence tomography (OCT) might allow identifying lesion features reportedly associated with plaque vulnerability and increased risk of clinical events. Previous studies on correlation between OCT and functional lesion significance indices reported contradictory results, yet int...

Descripción completa

Detalles Bibliográficos
Autores principales: Tomaniak, Mariusz, Ochijewicz, Dorota, Kołtowski, Łukasz, Rdzanek, Adam, Pietrasik, Arkadiusz, Jąkała, Jacek, Slezak, Magdalena, Malinowski, Krzysztof P., Zaleska, Martyna, Maksym, Jakub, Barus, Piotr, Roleder, Tomasz, Filipiak, Krzysztof J., Opolski, Grzegorz, Kochman, Janusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197966/
https://www.ncbi.nlm.nih.gov/pubmed/34071299
http://dx.doi.org/10.3390/jcm10112379
_version_ 1783707025286365184
author Tomaniak, Mariusz
Ochijewicz, Dorota
Kołtowski, Łukasz
Rdzanek, Adam
Pietrasik, Arkadiusz
Jąkała, Jacek
Slezak, Magdalena
Malinowski, Krzysztof P.
Zaleska, Martyna
Maksym, Jakub
Barus, Piotr
Roleder, Tomasz
Filipiak, Krzysztof J.
Opolski, Grzegorz
Kochman, Janusz
author_facet Tomaniak, Mariusz
Ochijewicz, Dorota
Kołtowski, Łukasz
Rdzanek, Adam
Pietrasik, Arkadiusz
Jąkała, Jacek
Slezak, Magdalena
Malinowski, Krzysztof P.
Zaleska, Martyna
Maksym, Jakub
Barus, Piotr
Roleder, Tomasz
Filipiak, Krzysztof J.
Opolski, Grzegorz
Kochman, Janusz
author_sort Tomaniak, Mariusz
collection PubMed
description Background: optical coherence tomography (OCT) might allow identifying lesion features reportedly associated with plaque vulnerability and increased risk of clinical events. Previous studies on correlation between OCT and functional lesion significance indices reported contradictory results, yet integration of complementary information from both modalities is gaining increased interest. The aim of the study was to compare plaque morphology using OCT in hemodynamically relevant vs. non-relevant lesions by fractional flow reserve (FFR). Methods: consecutive patients with intermediate grade coronary stenoses by angiography were evaluated by both FFR and OCT in this single-center study. Stenoses were labeled hemodynamically relevant in case of the FFR ≤ 0.80. Minimal lumen area (MLA), fibrous cap thickness (FCT), minimal cap thickness over the calcium, angle of the calcium, and necrotic core within the lesions were evaluated. Results: a total of 105 patients (124 vessels) were analyzed. Of them, 65 patients were identified with at least one lesion identified as hemodynamically relevant by FFR (72 vessels, 58.1%). Lesions with FFR ≤0.80 presented with lower mean and minimal lumen area (3.46 ± 1.29 vs. 4.65 ± 2.19, p =0.001 and 1.84 ± 0.97 vs. 2.66 ± 1.40, p = 0.001) compared to patients with FFR > 0.80. No differences were found between groups in the mean and minimal FCT, mean, and maximal necrotic core, calcium angle, as well as the overall rate of calcified and lipid plaques. Conclusion: hemodynamic relevance of intermediate grade lesions correlated moderately with the luminal assessment by OCT. No differences were identified in the plaque morphology between relevant and non-relevant coronary stenoses by FFR.
format Online
Article
Text
id pubmed-8197966
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81979662021-06-14 OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses Tomaniak, Mariusz Ochijewicz, Dorota Kołtowski, Łukasz Rdzanek, Adam Pietrasik, Arkadiusz Jąkała, Jacek Slezak, Magdalena Malinowski, Krzysztof P. Zaleska, Martyna Maksym, Jakub Barus, Piotr Roleder, Tomasz Filipiak, Krzysztof J. Opolski, Grzegorz Kochman, Janusz J Clin Med Article Background: optical coherence tomography (OCT) might allow identifying lesion features reportedly associated with plaque vulnerability and increased risk of clinical events. Previous studies on correlation between OCT and functional lesion significance indices reported contradictory results, yet integration of complementary information from both modalities is gaining increased interest. The aim of the study was to compare plaque morphology using OCT in hemodynamically relevant vs. non-relevant lesions by fractional flow reserve (FFR). Methods: consecutive patients with intermediate grade coronary stenoses by angiography were evaluated by both FFR and OCT in this single-center study. Stenoses were labeled hemodynamically relevant in case of the FFR ≤ 0.80. Minimal lumen area (MLA), fibrous cap thickness (FCT), minimal cap thickness over the calcium, angle of the calcium, and necrotic core within the lesions were evaluated. Results: a total of 105 patients (124 vessels) were analyzed. Of them, 65 patients were identified with at least one lesion identified as hemodynamically relevant by FFR (72 vessels, 58.1%). Lesions with FFR ≤0.80 presented with lower mean and minimal lumen area (3.46 ± 1.29 vs. 4.65 ± 2.19, p =0.001 and 1.84 ± 0.97 vs. 2.66 ± 1.40, p = 0.001) compared to patients with FFR > 0.80. No differences were found between groups in the mean and minimal FCT, mean, and maximal necrotic core, calcium angle, as well as the overall rate of calcified and lipid plaques. Conclusion: hemodynamic relevance of intermediate grade lesions correlated moderately with the luminal assessment by OCT. No differences were identified in the plaque morphology between relevant and non-relevant coronary stenoses by FFR. MDPI 2021-05-28 /pmc/articles/PMC8197966/ /pubmed/34071299 http://dx.doi.org/10.3390/jcm10112379 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tomaniak, Mariusz
Ochijewicz, Dorota
Kołtowski, Łukasz
Rdzanek, Adam
Pietrasik, Arkadiusz
Jąkała, Jacek
Slezak, Magdalena
Malinowski, Krzysztof P.
Zaleska, Martyna
Maksym, Jakub
Barus, Piotr
Roleder, Tomasz
Filipiak, Krzysztof J.
Opolski, Grzegorz
Kochman, Janusz
OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses
title OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses
title_full OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses
title_fullStr OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses
title_full_unstemmed OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses
title_short OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses
title_sort oct-derived plaque morphology and ffr-determined hemodynamic relevance in intermediate coronary stenoses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197966/
https://www.ncbi.nlm.nih.gov/pubmed/34071299
http://dx.doi.org/10.3390/jcm10112379
work_keys_str_mv AT tomaniakmariusz octderivedplaquemorphologyandffrdeterminedhemodynamicrelevanceinintermediatecoronarystenoses
AT ochijewiczdorota octderivedplaquemorphologyandffrdeterminedhemodynamicrelevanceinintermediatecoronarystenoses
AT kołtowskiłukasz octderivedplaquemorphologyandffrdeterminedhemodynamicrelevanceinintermediatecoronarystenoses
AT rdzanekadam octderivedplaquemorphologyandffrdeterminedhemodynamicrelevanceinintermediatecoronarystenoses
AT pietrasikarkadiusz octderivedplaquemorphologyandffrdeterminedhemodynamicrelevanceinintermediatecoronarystenoses
AT jakałajacek octderivedplaquemorphologyandffrdeterminedhemodynamicrelevanceinintermediatecoronarystenoses
AT slezakmagdalena octderivedplaquemorphologyandffrdeterminedhemodynamicrelevanceinintermediatecoronarystenoses
AT malinowskikrzysztofp octderivedplaquemorphologyandffrdeterminedhemodynamicrelevanceinintermediatecoronarystenoses
AT zaleskamartyna octderivedplaquemorphologyandffrdeterminedhemodynamicrelevanceinintermediatecoronarystenoses
AT maksymjakub octderivedplaquemorphologyandffrdeterminedhemodynamicrelevanceinintermediatecoronarystenoses
AT baruspiotr octderivedplaquemorphologyandffrdeterminedhemodynamicrelevanceinintermediatecoronarystenoses
AT roledertomasz octderivedplaquemorphologyandffrdeterminedhemodynamicrelevanceinintermediatecoronarystenoses
AT filipiakkrzysztofj octderivedplaquemorphologyandffrdeterminedhemodynamicrelevanceinintermediatecoronarystenoses
AT opolskigrzegorz octderivedplaquemorphologyandffrdeterminedhemodynamicrelevanceinintermediatecoronarystenoses
AT kochmanjanusz octderivedplaquemorphologyandffrdeterminedhemodynamicrelevanceinintermediatecoronarystenoses