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OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses
Background: optical coherence tomography (OCT) might allow identifying lesion features reportedly associated with plaque vulnerability and increased risk of clinical events. Previous studies on correlation between OCT and functional lesion significance indices reported contradictory results, yet int...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197966/ https://www.ncbi.nlm.nih.gov/pubmed/34071299 http://dx.doi.org/10.3390/jcm10112379 |
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author | Tomaniak, Mariusz Ochijewicz, Dorota Kołtowski, Łukasz Rdzanek, Adam Pietrasik, Arkadiusz Jąkała, Jacek Slezak, Magdalena Malinowski, Krzysztof P. Zaleska, Martyna Maksym, Jakub Barus, Piotr Roleder, Tomasz Filipiak, Krzysztof J. Opolski, Grzegorz Kochman, Janusz |
author_facet | Tomaniak, Mariusz Ochijewicz, Dorota Kołtowski, Łukasz Rdzanek, Adam Pietrasik, Arkadiusz Jąkała, Jacek Slezak, Magdalena Malinowski, Krzysztof P. Zaleska, Martyna Maksym, Jakub Barus, Piotr Roleder, Tomasz Filipiak, Krzysztof J. Opolski, Grzegorz Kochman, Janusz |
author_sort | Tomaniak, Mariusz |
collection | PubMed |
description | Background: optical coherence tomography (OCT) might allow identifying lesion features reportedly associated with plaque vulnerability and increased risk of clinical events. Previous studies on correlation between OCT and functional lesion significance indices reported contradictory results, yet integration of complementary information from both modalities is gaining increased interest. The aim of the study was to compare plaque morphology using OCT in hemodynamically relevant vs. non-relevant lesions by fractional flow reserve (FFR). Methods: consecutive patients with intermediate grade coronary stenoses by angiography were evaluated by both FFR and OCT in this single-center study. Stenoses were labeled hemodynamically relevant in case of the FFR ≤ 0.80. Minimal lumen area (MLA), fibrous cap thickness (FCT), minimal cap thickness over the calcium, angle of the calcium, and necrotic core within the lesions were evaluated. Results: a total of 105 patients (124 vessels) were analyzed. Of them, 65 patients were identified with at least one lesion identified as hemodynamically relevant by FFR (72 vessels, 58.1%). Lesions with FFR ≤0.80 presented with lower mean and minimal lumen area (3.46 ± 1.29 vs. 4.65 ± 2.19, p =0.001 and 1.84 ± 0.97 vs. 2.66 ± 1.40, p = 0.001) compared to patients with FFR > 0.80. No differences were found between groups in the mean and minimal FCT, mean, and maximal necrotic core, calcium angle, as well as the overall rate of calcified and lipid plaques. Conclusion: hemodynamic relevance of intermediate grade lesions correlated moderately with the luminal assessment by OCT. No differences were identified in the plaque morphology between relevant and non-relevant coronary stenoses by FFR. |
format | Online Article Text |
id | pubmed-8197966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81979662021-06-14 OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses Tomaniak, Mariusz Ochijewicz, Dorota Kołtowski, Łukasz Rdzanek, Adam Pietrasik, Arkadiusz Jąkała, Jacek Slezak, Magdalena Malinowski, Krzysztof P. Zaleska, Martyna Maksym, Jakub Barus, Piotr Roleder, Tomasz Filipiak, Krzysztof J. Opolski, Grzegorz Kochman, Janusz J Clin Med Article Background: optical coherence tomography (OCT) might allow identifying lesion features reportedly associated with plaque vulnerability and increased risk of clinical events. Previous studies on correlation between OCT and functional lesion significance indices reported contradictory results, yet integration of complementary information from both modalities is gaining increased interest. The aim of the study was to compare plaque morphology using OCT in hemodynamically relevant vs. non-relevant lesions by fractional flow reserve (FFR). Methods: consecutive patients with intermediate grade coronary stenoses by angiography were evaluated by both FFR and OCT in this single-center study. Stenoses were labeled hemodynamically relevant in case of the FFR ≤ 0.80. Minimal lumen area (MLA), fibrous cap thickness (FCT), minimal cap thickness over the calcium, angle of the calcium, and necrotic core within the lesions were evaluated. Results: a total of 105 patients (124 vessels) were analyzed. Of them, 65 patients were identified with at least one lesion identified as hemodynamically relevant by FFR (72 vessels, 58.1%). Lesions with FFR ≤0.80 presented with lower mean and minimal lumen area (3.46 ± 1.29 vs. 4.65 ± 2.19, p =0.001 and 1.84 ± 0.97 vs. 2.66 ± 1.40, p = 0.001) compared to patients with FFR > 0.80. No differences were found between groups in the mean and minimal FCT, mean, and maximal necrotic core, calcium angle, as well as the overall rate of calcified and lipid plaques. Conclusion: hemodynamic relevance of intermediate grade lesions correlated moderately with the luminal assessment by OCT. No differences were identified in the plaque morphology between relevant and non-relevant coronary stenoses by FFR. MDPI 2021-05-28 /pmc/articles/PMC8197966/ /pubmed/34071299 http://dx.doi.org/10.3390/jcm10112379 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tomaniak, Mariusz Ochijewicz, Dorota Kołtowski, Łukasz Rdzanek, Adam Pietrasik, Arkadiusz Jąkała, Jacek Slezak, Magdalena Malinowski, Krzysztof P. Zaleska, Martyna Maksym, Jakub Barus, Piotr Roleder, Tomasz Filipiak, Krzysztof J. Opolski, Grzegorz Kochman, Janusz OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses |
title | OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses |
title_full | OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses |
title_fullStr | OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses |
title_full_unstemmed | OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses |
title_short | OCT-Derived Plaque Morphology and FFR-Determined Hemodynamic Relevance in Intermediate Coronary Stenoses |
title_sort | oct-derived plaque morphology and ffr-determined hemodynamic relevance in intermediate coronary stenoses |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197966/ https://www.ncbi.nlm.nih.gov/pubmed/34071299 http://dx.doi.org/10.3390/jcm10112379 |
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