Combination Treatment of OSI-906 with Aurora B Inhibitor Reduces Cell Viability via Cyclin B1 Degradation-Induced Mitotic Slippage

Insulin-like growth factor 1 receptor (IGF1R), a receptor-type tyrosine kinase, transduces signals related to cell proliferation, survival, and differentiation. We recently reported that OSI-906, an IGF1R inhibitor, in combination with the Aurora B inhibitor ZM447439 suppresses cell proliferation. H...

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Detalles Bibliográficos
Autores principales: Ikeda, Yuki, Yasutake, Ryuji, Yuki, Ryuzaburo, Saito, Youhei, Nakayama, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197973/
https://www.ncbi.nlm.nih.gov/pubmed/34071893
http://dx.doi.org/10.3390/ijms22115706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197973/
https://www.ncbi.nlm.nih.gov/pubmed/34071893
http://dx.doi.org/10.3390/ijms22115706

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