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Combination Treatment of OSI-906 with Aurora B Inhibitor Reduces Cell Viability via Cyclin B1 Degradation-Induced Mitotic Slippage

Insulin-like growth factor 1 receptor (IGF1R), a receptor-type tyrosine kinase, transduces signals related to cell proliferation, survival, and differentiation. We recently reported that OSI-906, an IGF1R inhibitor, in combination with the Aurora B inhibitor ZM447439 suppresses cell proliferation. H...

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Detalles Bibliográficos
Autores principales:	Ikeda, Yuki, Yasutake, Ryuji, Yuki, Ryuzaburo, Saito, Youhei, Nakayama, Yuji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8197973/ https://www.ncbi.nlm.nih.gov/pubmed/34071893 http://dx.doi.org/10.3390/ijms22115706

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