PDS5A and PDS5B in Cohesin Function and Human Disease

Precocious dissociation of sisters 5 (PDS5) is an associate protein of cohesin that is conserved from yeast to humans. It acts as a regulator of the cohesin complex and plays important roles in various cellular processes, such as sister chromatid cohesion, DNA damage repair, gene transcription, and...

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Detalles Bibliográficos
Autores principales: Zhang, Nenggang, Coutinho, Luiza E., Pati, Debananda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198109/
https://www.ncbi.nlm.nih.gov/pubmed/34070827
http://dx.doi.org/10.3390/ijms22115868
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author Zhang, Nenggang
Coutinho, Luiza E.
Pati, Debananda
author_facet Zhang, Nenggang
Coutinho, Luiza E.
Pati, Debananda
author_sort Zhang, Nenggang
collection PubMed
description Precocious dissociation of sisters 5 (PDS5) is an associate protein of cohesin that is conserved from yeast to humans. It acts as a regulator of the cohesin complex and plays important roles in various cellular processes, such as sister chromatid cohesion, DNA damage repair, gene transcription, and DNA replication. Vertebrates have two paralogs of PDS5, PDS5A and PDS5B, which have redundant and unique roles in regulating cohesin functions. Herein, we discuss the molecular characteristics and functions of PDS5, as well as the effects of its mutations in the development of diseases and their relevance for novel therapeutic strategies.
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spelling pubmed-81981092021-06-14 PDS5A and PDS5B in Cohesin Function and Human Disease Zhang, Nenggang Coutinho, Luiza E. Pati, Debananda Int J Mol Sci Review Precocious dissociation of sisters 5 (PDS5) is an associate protein of cohesin that is conserved from yeast to humans. It acts as a regulator of the cohesin complex and plays important roles in various cellular processes, such as sister chromatid cohesion, DNA damage repair, gene transcription, and DNA replication. Vertebrates have two paralogs of PDS5, PDS5A and PDS5B, which have redundant and unique roles in regulating cohesin functions. Herein, we discuss the molecular characteristics and functions of PDS5, as well as the effects of its mutations in the development of diseases and their relevance for novel therapeutic strategies. MDPI 2021-05-30 /pmc/articles/PMC8198109/ /pubmed/34070827 http://dx.doi.org/10.3390/ijms22115868 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Nenggang
Coutinho, Luiza E.
Pati, Debananda
PDS5A and PDS5B in Cohesin Function and Human Disease
title PDS5A and PDS5B in Cohesin Function and Human Disease
title_full PDS5A and PDS5B in Cohesin Function and Human Disease
title_fullStr PDS5A and PDS5B in Cohesin Function and Human Disease
title_full_unstemmed PDS5A and PDS5B in Cohesin Function and Human Disease
title_short PDS5A and PDS5B in Cohesin Function and Human Disease
title_sort pds5a and pds5b in cohesin function and human disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198109/
https://www.ncbi.nlm.nih.gov/pubmed/34070827
http://dx.doi.org/10.3390/ijms22115868
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