Cargando…

Structural Basis for the Diminished Ligand Binding and Catalytic Ability of Human Fetal-Specific CYP3A7

Cytochrome P450 3A7 (CYP3A7) is a fetal/neonatal liver enzyme that participates in estriol synthesis, clearance of all-trans retinoic acid, and xenobiotic metabolism. Compared to the closely related major drug-metabolizing enzyme in adult liver, CYP3A4, the ligand binding and catalytic capacity of C...

Descripción completa

Detalles Bibliográficos
Autor principal:	Sevrioukova, Irina F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198134/ https://www.ncbi.nlm.nih.gov/pubmed/34072457 http://dx.doi.org/10.3390/ijms22115831

Ejemplares similares

Crystal Structure of CYP3A4 Complexed with Fluorol Identifies the Substrate Access Channel as a High-Affinity Ligand Binding Site
por: Sevrioukova, Irina F.
Publicado: (2022)

Interaction of CYP3A4 with caffeine: First insights into multiple substrate binding
por: Sevrioukova, Irina F.
Publicado: (2023)

Rational Design of CYP3A4 Inhibitors: A One-Atom Linker Elongation in Ritonavir-Like Compounds Leads to a Marked Improvement in the Binding Strength
por: Samuels, Eric R., et al.
Publicado: (2021)

Structural Insights into the Interaction of Cytochrome P450 3A4 with Suicide Substrates: Mibefradil, Azamulin and 6′,7′-Dihydroxybergamottin
por: Sevrioukova, Irina F.
Publicado: (2019)

Interaction of CYP3A4 with Rationally Designed Ritonavir Analogues: Impact of Steric Constraints Imposed on the Heme-Ligating Group and the End-Pyridine Attachment
por: Samuels, Eric R., et al.
Publicado: (2022)

Structural basis of ligand binding modes of human EAAT2
por: Zhang, Zhenglai, et al.
Publicado: (2022)

Structural basis for ligand binding to the guanidine-II riboswitch
por: Reiss, Caroline W., et al.
Publicado: (2017)

Structural basis for ligand binding modes of CTP synthase
por: Zhou, Xian, et al.
Publicado: (2021)

Molecular basis for the substrate specificity and catalytic mechanism of thymine-7-hydroxylase in fungi
por: Li, Wenjing, et al.
Publicado: (2015)

Structural basis for human ZBTB7A action at the fetal globin promoter
por: Yang, Yang, et al.
Publicado: (2021)

Structural basis of the ligand binding and signaling mechanism of melatonin receptors
por: Wang, Qinggong, et al.
Publicado: (2022)

Structural basis of catalytic activation in human splicing
por: Schmitzová, Jana, et al.
Publicado: (2023)

Structural Basis of Specific Glucoimidazole and Mannoimidazole Binding by Os3BGlu7
por: Nutho, Bodee, et al.
Publicado: (2020)

Structural basis of ligand binding modes at the human formyl peptide receptor 2
por: Chen, Tong, et al.
Publicado: (2020)

Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7
por: Jaeger, Kathrin, et al.
Publicado: (2019)

Structural basis of CXC chemokine receptor 1 ligand binding and activation
por: Ishimoto, Naito, et al.
Publicado: (2023)

Tyrosine Nitroxidation Does Not Affect the Ability of α-Synuclein to Bind Anionic Micelles, but It Diminishes Its Ability to Bind and Assemble Synaptic-like Vesicles
por: Uceda, Ana Belén, et al.
Publicado: (2023)

Structural basis for conformational equilibrium of the catalytic spliceosome
por: Wilkinson, Max E., et al.
Publicado: (2021)

The catalytic and structural basis of archaeal glycerophospholipid biosynthesis
por: de Kok, Niels A. W., et al.
Publicado: (2022)

Computational Elucidation of Structural Basis for Ligand Binding with Leishmania donovani Adenosine Kinase
por: Kar, Rajiv K., et al.
Publicado: (2013)

Structural basis of ligand binding modes at the neuropeptide Y Y(1) receptor
por: Yang, Zhenlin, et al.
Publicado: (2018)

Structural basis of hydroxycarboxylic acid receptor signaling mechanisms through ligand binding
por: Suzuki, Shota, et al.
Publicado: (2023)

Structural basis of peroxidase catalytic cycle of human Prdx6
por: Chowhan, Rimpy Kaur, et al.
Publicado: (2020)

Structural basis for the substrate specificity and catalytic features of pseudouridine kinase from Arabidopsis thaliana
por: Kim, Sang-Hoon, et al.
Publicado: (2020)

Fetal intraperitoneal injection of immunoglobulin diminishes alloimmune hemolysis
por: Matsuda, H, et al.
Publicado: (2011)

Ant Homing Ability Is Not Diminished When Traveling Backwards
por: Ardin, Paul B., et al.
Publicado: (2016)

Structural basis for substrate binding and catalytic mechanism of a human RNA:m(5)C methyltransferase NSun6
por: Liu, Ru-Juan, et al.
Publicado: (2017)

Crystal structure of an atypical cobalamin riboswitch reveals RNA structural adaptability as basis for promiscuous ligand binding
por: Chan, Clarence W, et al.
Publicado: (2020)

Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface
por: Heo, Yunseok, et al.
Publicado: (2022)

Structural basis of ligand interaction with atypical chemokine receptor 3
por: Gustavsson, Martin, et al.
Publicado: (2017)

Structural Basis for Variant-Specific Neuroligin-Binding by α-Neurexin
por: Tanaka, Hiroki, et al.
Publicado: (2011)

Structural basis for the ligand recognition and signaling of free fatty acid receptors
por: Zhang, Xuan, et al.
Publicado: (2023)

Structural basis of steroid binding and oxidation by the cytochrome P450 CYP109E1 from Bacillus megaterium
por: Jóźwik, Ilona K., et al.
Publicado: (2016)

Structural basis for PPAR partial or full activation revealed by a novel ligand binding mode
por: Capelli, Davide, et al.
Publicado: (2016)

Structural basis for the ligand promiscuity of the neofunctionalized, carotenoid-binding fasciclin domain protein AstaP
por: Kornilov, Fedor D., et al.
Publicado: (2023)

Mechanism of Selective VEGF-A Binding by Neuropilin-1 Reveals a Basis for Specific Ligand Inhibition
por: Parker, Matthew W., et al.
Publicado: (2012)

Structural Basis of VSIG3: The Ligand for VISTA
por: Xie, Xiaoxue, et al.
Publicado: (2021)

Hesperetin—Between the Ability to Diminish Mono- and Polymicrobial Biofilms and Toxicity
por: Carević, Tamara, et al.
Publicado: (2022)

Structural basis for the activation and ligand recognition of the human oxytocin receptor
por: Waltenspühl, Yann, et al.
Publicado: (2022)

The Molecular Basis for Specificity at the Level of the Protein Kinase a Catalytic Subunit
por: Søberg, Kristoffer, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ovc1ouhu8vn3jfo10pudh135pv