Cargando…
Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer
Four new ligands and four new copper (II) coordination compounds were prepared and characterized by chemical, elemental analysis, cytotoxicity, and FTIR spectroscopy (Fourier transform infrared spectroscopy). The nature of metal–ligand coordination was investigated. The thermal properties of complex...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198142/ https://www.ncbi.nlm.nih.gov/pubmed/34070886 http://dx.doi.org/10.3390/ma14112958 |
_version_ | 1783707067261911040 |
---|---|
author | Raducka, Anita Czylkowska, Agnieszka Gobis, Katarzyna Czarnecka, Kamila Szymański, Paweł Świątkowski, Marcin |
author_facet | Raducka, Anita Czylkowska, Agnieszka Gobis, Katarzyna Czarnecka, Kamila Szymański, Paweł Świątkowski, Marcin |
author_sort | Raducka, Anita |
collection | PubMed |
description | Four new ligands and four new copper (II) coordination compounds were prepared and characterized by chemical, elemental analysis, cytotoxicity, and FTIR spectroscopy (Fourier transform infrared spectroscopy). The nature of metal–ligand coordination was investigated. The thermal properties of complexes in the solid state were studied using TG-MS techniques (thermogravimetric analysis coupled with mass spectrometry) under dynamic flowing air atmosphere to analyze the principal volatile thermal decomposition and fragmentation products that evolved during thermolysis. The intermediate and final solid thermolysis products were also determined. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide) assay was used to evaluate active metabolic cells as an IC(50) (half maximal inhibitory concentration). The relationship between antitumor activity and the position of nitrogen atoms in the organic ligand has been shown. |
format | Online Article Text |
id | pubmed-8198142 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81981422021-06-14 Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer Raducka, Anita Czylkowska, Agnieszka Gobis, Katarzyna Czarnecka, Kamila Szymański, Paweł Świątkowski, Marcin Materials (Basel) Communication Four new ligands and four new copper (II) coordination compounds were prepared and characterized by chemical, elemental analysis, cytotoxicity, and FTIR spectroscopy (Fourier transform infrared spectroscopy). The nature of metal–ligand coordination was investigated. The thermal properties of complexes in the solid state were studied using TG-MS techniques (thermogravimetric analysis coupled with mass spectrometry) under dynamic flowing air atmosphere to analyze the principal volatile thermal decomposition and fragmentation products that evolved during thermolysis. The intermediate and final solid thermolysis products were also determined. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide) assay was used to evaluate active metabolic cells as an IC(50) (half maximal inhibitory concentration). The relationship between antitumor activity and the position of nitrogen atoms in the organic ligand has been shown. MDPI 2021-05-30 /pmc/articles/PMC8198142/ /pubmed/34070886 http://dx.doi.org/10.3390/ma14112958 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Raducka, Anita Czylkowska, Agnieszka Gobis, Katarzyna Czarnecka, Kamila Szymański, Paweł Świątkowski, Marcin Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer |
title | Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer |
title_full | Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer |
title_fullStr | Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer |
title_full_unstemmed | Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer |
title_short | Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer |
title_sort | characterization of metal-bound benzimidazole derivatives, effects on tumor cells of lung cancer |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198142/ https://www.ncbi.nlm.nih.gov/pubmed/34070886 http://dx.doi.org/10.3390/ma14112958 |
work_keys_str_mv | AT raduckaanita characterizationofmetalboundbenzimidazolederivativeseffectsontumorcellsoflungcancer AT czylkowskaagnieszka characterizationofmetalboundbenzimidazolederivativeseffectsontumorcellsoflungcancer AT gobiskatarzyna characterizationofmetalboundbenzimidazolederivativeseffectsontumorcellsoflungcancer AT czarneckakamila characterizationofmetalboundbenzimidazolederivativeseffectsontumorcellsoflungcancer AT szymanskipaweł characterizationofmetalboundbenzimidazolederivativeseffectsontumorcellsoflungcancer AT swiatkowskimarcin characterizationofmetalboundbenzimidazolederivativeseffectsontumorcellsoflungcancer |