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Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer

Four new ligands and four new copper (II) coordination compounds were prepared and characterized by chemical, elemental analysis, cytotoxicity, and FTIR spectroscopy (Fourier transform infrared spectroscopy). The nature of metal–ligand coordination was investigated. The thermal properties of complex...

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Detalles Bibliográficos
Autores principales: Raducka, Anita, Czylkowska, Agnieszka, Gobis, Katarzyna, Czarnecka, Kamila, Szymański, Paweł, Świątkowski, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198142/
https://www.ncbi.nlm.nih.gov/pubmed/34070886
http://dx.doi.org/10.3390/ma14112958
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author Raducka, Anita
Czylkowska, Agnieszka
Gobis, Katarzyna
Czarnecka, Kamila
Szymański, Paweł
Świątkowski, Marcin
author_facet Raducka, Anita
Czylkowska, Agnieszka
Gobis, Katarzyna
Czarnecka, Kamila
Szymański, Paweł
Świątkowski, Marcin
author_sort Raducka, Anita
collection PubMed
description Four new ligands and four new copper (II) coordination compounds were prepared and characterized by chemical, elemental analysis, cytotoxicity, and FTIR spectroscopy (Fourier transform infrared spectroscopy). The nature of metal–ligand coordination was investigated. The thermal properties of complexes in the solid state were studied using TG-MS techniques (thermogravimetric analysis coupled with mass spectrometry) under dynamic flowing air atmosphere to analyze the principal volatile thermal decomposition and fragmentation products that evolved during thermolysis. The intermediate and final solid thermolysis products were also determined. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide) assay was used to evaluate active metabolic cells as an IC(50) (half maximal inhibitory concentration). The relationship between antitumor activity and the position of nitrogen atoms in the organic ligand has been shown.
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spelling pubmed-81981422021-06-14 Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer Raducka, Anita Czylkowska, Agnieszka Gobis, Katarzyna Czarnecka, Kamila Szymański, Paweł Świątkowski, Marcin Materials (Basel) Communication Four new ligands and four new copper (II) coordination compounds were prepared and characterized by chemical, elemental analysis, cytotoxicity, and FTIR spectroscopy (Fourier transform infrared spectroscopy). The nature of metal–ligand coordination was investigated. The thermal properties of complexes in the solid state were studied using TG-MS techniques (thermogravimetric analysis coupled with mass spectrometry) under dynamic flowing air atmosphere to analyze the principal volatile thermal decomposition and fragmentation products that evolved during thermolysis. The intermediate and final solid thermolysis products were also determined. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazoliumbromide) assay was used to evaluate active metabolic cells as an IC(50) (half maximal inhibitory concentration). The relationship between antitumor activity and the position of nitrogen atoms in the organic ligand has been shown. MDPI 2021-05-30 /pmc/articles/PMC8198142/ /pubmed/34070886 http://dx.doi.org/10.3390/ma14112958 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Raducka, Anita
Czylkowska, Agnieszka
Gobis, Katarzyna
Czarnecka, Kamila
Szymański, Paweł
Świątkowski, Marcin
Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer
title Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer
title_full Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer
title_fullStr Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer
title_full_unstemmed Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer
title_short Characterization of Metal-Bound Benzimidazole Derivatives, Effects on Tumor Cells of Lung Cancer
title_sort characterization of metal-bound benzimidazole derivatives, effects on tumor cells of lung cancer
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198142/
https://www.ncbi.nlm.nih.gov/pubmed/34070886
http://dx.doi.org/10.3390/ma14112958
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