Cargando…
Safety, Efficacy, and Outcomes of N-Butyl Cyanoacrylate Glue Injection through the Endoscopic or Radiologic Route for Variceal Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis
We performed a systematic review and meta-analysis of published studies to assess the efficacy, safety, and outcomes of N-butyl cyanoacrylate (NBCA) injection for the treatment of variceal gastrointestinal bleeding (GIB). The MEDLINE/PubMed, EMBASE, and SCOPUS databases were searched for English-lan...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198169/ https://www.ncbi.nlm.nih.gov/pubmed/34070534 http://dx.doi.org/10.3390/jcm10112298 |
_version_ | 1783707073704361984 |
---|---|
author | Chevallier, Olivier Guillen, Kévin Comby, Pierre-Olivier Mouillot, Thomas Falvo, Nicolas Bardou, Marc Midulla, Marco Aho-Glélé, Ludwig-Serge Loffroy, Romaric |
author_facet | Chevallier, Olivier Guillen, Kévin Comby, Pierre-Olivier Mouillot, Thomas Falvo, Nicolas Bardou, Marc Midulla, Marco Aho-Glélé, Ludwig-Serge Loffroy, Romaric |
author_sort | Chevallier, Olivier |
collection | PubMed |
description | We performed a systematic review and meta-analysis of published studies to assess the efficacy, safety, and outcomes of N-butyl cyanoacrylate (NBCA) injection for the treatment of variceal gastrointestinal bleeding (GIB). The MEDLINE/PubMed, EMBASE, and SCOPUS databases were searched for English-language studies published from January 1980 to December 2019 and including patients who had injection of NBCA for variceal GIB. Two independent reviewers extracted and evaluated the data from eligible studies. Exclusion criteria were sample size < 5, article reporting the use of NBCA with other embolic agents, no extractable data, and duplicate reports. NBCA was injected during endoscopy in 42 studies and through a direct percutaneous approach for stomal varices in 1 study. The study’s endpoints were: Technical success, 30-day rebleeding, and 30-day overall and major complications. The estimated overall rates were computed with 95% confidence intervals, based on each study rate, weighted by the number of patients involved in each study. In total, 43 studies with 3484 patients were included. The technical success rate was 94.1% (95% CI: 91.6–96.1%), the 30-day rebleeding rate was 24.2% (18.9–29.9%), and 30-day overall and major complications occurred in 15.9% (11.2–21.3%) and 5.3% (3.3–7.8%) of patients, respectively. For treating variceal GIB, NBCA injection is a safe and effective method that demonstrates high technical success rate and very low major complication rate. |
format | Online Article Text |
id | pubmed-8198169 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81981692021-06-14 Safety, Efficacy, and Outcomes of N-Butyl Cyanoacrylate Glue Injection through the Endoscopic or Radiologic Route for Variceal Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis Chevallier, Olivier Guillen, Kévin Comby, Pierre-Olivier Mouillot, Thomas Falvo, Nicolas Bardou, Marc Midulla, Marco Aho-Glélé, Ludwig-Serge Loffroy, Romaric J Clin Med Review We performed a systematic review and meta-analysis of published studies to assess the efficacy, safety, and outcomes of N-butyl cyanoacrylate (NBCA) injection for the treatment of variceal gastrointestinal bleeding (GIB). The MEDLINE/PubMed, EMBASE, and SCOPUS databases were searched for English-language studies published from January 1980 to December 2019 and including patients who had injection of NBCA for variceal GIB. Two independent reviewers extracted and evaluated the data from eligible studies. Exclusion criteria were sample size < 5, article reporting the use of NBCA with other embolic agents, no extractable data, and duplicate reports. NBCA was injected during endoscopy in 42 studies and through a direct percutaneous approach for stomal varices in 1 study. The study’s endpoints were: Technical success, 30-day rebleeding, and 30-day overall and major complications. The estimated overall rates were computed with 95% confidence intervals, based on each study rate, weighted by the number of patients involved in each study. In total, 43 studies with 3484 patients were included. The technical success rate was 94.1% (95% CI: 91.6–96.1%), the 30-day rebleeding rate was 24.2% (18.9–29.9%), and 30-day overall and major complications occurred in 15.9% (11.2–21.3%) and 5.3% (3.3–7.8%) of patients, respectively. For treating variceal GIB, NBCA injection is a safe and effective method that demonstrates high technical success rate and very low major complication rate. MDPI 2021-05-25 /pmc/articles/PMC8198169/ /pubmed/34070534 http://dx.doi.org/10.3390/jcm10112298 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chevallier, Olivier Guillen, Kévin Comby, Pierre-Olivier Mouillot, Thomas Falvo, Nicolas Bardou, Marc Midulla, Marco Aho-Glélé, Ludwig-Serge Loffroy, Romaric Safety, Efficacy, and Outcomes of N-Butyl Cyanoacrylate Glue Injection through the Endoscopic or Radiologic Route for Variceal Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis |
title | Safety, Efficacy, and Outcomes of N-Butyl Cyanoacrylate Glue Injection through the Endoscopic or Radiologic Route for Variceal Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis |
title_full | Safety, Efficacy, and Outcomes of N-Butyl Cyanoacrylate Glue Injection through the Endoscopic or Radiologic Route for Variceal Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis |
title_fullStr | Safety, Efficacy, and Outcomes of N-Butyl Cyanoacrylate Glue Injection through the Endoscopic or Radiologic Route for Variceal Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis |
title_full_unstemmed | Safety, Efficacy, and Outcomes of N-Butyl Cyanoacrylate Glue Injection through the Endoscopic or Radiologic Route for Variceal Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis |
title_short | Safety, Efficacy, and Outcomes of N-Butyl Cyanoacrylate Glue Injection through the Endoscopic or Radiologic Route for Variceal Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis |
title_sort | safety, efficacy, and outcomes of n-butyl cyanoacrylate glue injection through the endoscopic or radiologic route for variceal gastrointestinal bleeding: a systematic review and meta-analysis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198169/ https://www.ncbi.nlm.nih.gov/pubmed/34070534 http://dx.doi.org/10.3390/jcm10112298 |
work_keys_str_mv | AT chevallierolivier safetyefficacyandoutcomesofnbutylcyanoacrylateglueinjectionthroughtheendoscopicorradiologicrouteforvaricealgastrointestinalbleedingasystematicreviewandmetaanalysis AT guillenkevin safetyefficacyandoutcomesofnbutylcyanoacrylateglueinjectionthroughtheendoscopicorradiologicrouteforvaricealgastrointestinalbleedingasystematicreviewandmetaanalysis AT combypierreolivier safetyefficacyandoutcomesofnbutylcyanoacrylateglueinjectionthroughtheendoscopicorradiologicrouteforvaricealgastrointestinalbleedingasystematicreviewandmetaanalysis AT mouillotthomas safetyefficacyandoutcomesofnbutylcyanoacrylateglueinjectionthroughtheendoscopicorradiologicrouteforvaricealgastrointestinalbleedingasystematicreviewandmetaanalysis AT falvonicolas safetyefficacyandoutcomesofnbutylcyanoacrylateglueinjectionthroughtheendoscopicorradiologicrouteforvaricealgastrointestinalbleedingasystematicreviewandmetaanalysis AT bardoumarc safetyefficacyandoutcomesofnbutylcyanoacrylateglueinjectionthroughtheendoscopicorradiologicrouteforvaricealgastrointestinalbleedingasystematicreviewandmetaanalysis AT midullamarco safetyefficacyandoutcomesofnbutylcyanoacrylateglueinjectionthroughtheendoscopicorradiologicrouteforvaricealgastrointestinalbleedingasystematicreviewandmetaanalysis AT ahogleleludwigserge safetyefficacyandoutcomesofnbutylcyanoacrylateglueinjectionthroughtheendoscopicorradiologicrouteforvaricealgastrointestinalbleedingasystematicreviewandmetaanalysis AT loffroyromaric safetyefficacyandoutcomesofnbutylcyanoacrylateglueinjectionthroughtheendoscopicorradiologicrouteforvaricealgastrointestinalbleedingasystematicreviewandmetaanalysis |