Synthesis and Biological Evaluation of Spirocyclic Chromane Derivatives as a Potential Treatment of Prostate Cancer

As a significant co-activator involved in cell cycle and cell growth, differentiation and development, p300/CBP has shown extraordinary potential target in cancer therapy. Herein we designed new compounds from the lead compound A-485 based on molecular dynamic simulations. A series of new spirocycli...

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Detalles Bibliográficos
Autores principales: Feng, Li, Yu, Shujia, Wang, Hai, Yang, Shengwei, Li, Xue, Dai, Hongjuan, Zhao, Liwen, Jiang, Cheng, Wang, Yazhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198214/
https://www.ncbi.nlm.nih.gov/pubmed/34070610
http://dx.doi.org/10.3390/molecules26113162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198214/
https://www.ncbi.nlm.nih.gov/pubmed/34070610
http://dx.doi.org/10.3390/molecules26113162

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