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Synthesis and Biological Evaluation of Spirocyclic Chromane Derivatives as a Potential Treatment of Prostate Cancer
As a significant co-activator involved in cell cycle and cell growth, differentiation and development, p300/CBP has shown extraordinary potential target in cancer therapy. Herein we designed new compounds from the lead compound A-485 based on molecular dynamic simulations. A series of new spirocycli...
Autores principales: | Feng, Li, Yu, Shujia, Wang, Hai, Yang, Shengwei, Li, Xue, Dai, Hongjuan, Zhao, Liwen, Jiang, Cheng, Wang, Yazhou |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198214/ https://www.ncbi.nlm.nih.gov/pubmed/34070610 http://dx.doi.org/10.3390/molecules26113162 |
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