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Adverse Health Effects in Women Farmers Indirectly Exposed to Pesticides
Farmers are among the most vulnerable populations because of the exposure to low levels of pesticides. Acetylcholinesterase and butyrylcholinesterase activities are considered as biomarkers of pesticides poisoning. However, biomarkers of oxidative stress are also playing an important role in toxicit...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198255/ https://www.ncbi.nlm.nih.gov/pubmed/34072924 http://dx.doi.org/10.3390/ijerph18115909 |
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author | Martin-Reina, Jose Casanova, Alfredo G. Dahiri, Bouchra Fernández, Isaías Fernández-Palacín, Ana Bautista, Juan Morales, Ana I. Moreno, Isabel |
author_facet | Martin-Reina, Jose Casanova, Alfredo G. Dahiri, Bouchra Fernández, Isaías Fernández-Palacín, Ana Bautista, Juan Morales, Ana I. Moreno, Isabel |
author_sort | Martin-Reina, Jose |
collection | PubMed |
description | Farmers are among the most vulnerable populations because of the exposure to low levels of pesticides. Acetylcholinesterase and butyrylcholinesterase activities are considered as biomarkers of pesticides poisoning. However, biomarkers of oxidative stress are also playing an important role in toxicity of these contaminants. Further, increased activities of gamma-glutamyltransferase, alanine aminotransferase, urea and creatinine have been linked with hepatic and nephrotoxic cell damage, respectively. The aim of this study was to ascertain if the indirect exposure to pesticides leads to some biochemical parameter changes. Thus, cholinesterase activities, oxidative stress status (lipid and protein oxidation), hepatic function (AST and ALT levels), hormonal function (TSH, T4, FSH, LH and AMH), renal function (serum creatinine and urea), as well as possible subclinical kidney damage (urinary proteins and biomarkers of early kidney damage) were evaluated in farmer women who collect fruits and vegetables comparing with a group of women non-occupational exposed to pesticides but living in the same rural environment. Samples were taken periodically along one year to relate the observed effects to a chronic exposure. Our main results showed for the first time a subclinical kidney damage in a rural setting with indirect chronic exposure to pesticides. |
format | Online Article Text |
id | pubmed-8198255 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81982552021-06-14 Adverse Health Effects in Women Farmers Indirectly Exposed to Pesticides Martin-Reina, Jose Casanova, Alfredo G. Dahiri, Bouchra Fernández, Isaías Fernández-Palacín, Ana Bautista, Juan Morales, Ana I. Moreno, Isabel Int J Environ Res Public Health Article Farmers are among the most vulnerable populations because of the exposure to low levels of pesticides. Acetylcholinesterase and butyrylcholinesterase activities are considered as biomarkers of pesticides poisoning. However, biomarkers of oxidative stress are also playing an important role in toxicity of these contaminants. Further, increased activities of gamma-glutamyltransferase, alanine aminotransferase, urea and creatinine have been linked with hepatic and nephrotoxic cell damage, respectively. The aim of this study was to ascertain if the indirect exposure to pesticides leads to some biochemical parameter changes. Thus, cholinesterase activities, oxidative stress status (lipid and protein oxidation), hepatic function (AST and ALT levels), hormonal function (TSH, T4, FSH, LH and AMH), renal function (serum creatinine and urea), as well as possible subclinical kidney damage (urinary proteins and biomarkers of early kidney damage) were evaluated in farmer women who collect fruits and vegetables comparing with a group of women non-occupational exposed to pesticides but living in the same rural environment. Samples were taken periodically along one year to relate the observed effects to a chronic exposure. Our main results showed for the first time a subclinical kidney damage in a rural setting with indirect chronic exposure to pesticides. MDPI 2021-05-31 /pmc/articles/PMC8198255/ /pubmed/34072924 http://dx.doi.org/10.3390/ijerph18115909 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Martin-Reina, Jose Casanova, Alfredo G. Dahiri, Bouchra Fernández, Isaías Fernández-Palacín, Ana Bautista, Juan Morales, Ana I. Moreno, Isabel Adverse Health Effects in Women Farmers Indirectly Exposed to Pesticides |
title | Adverse Health Effects in Women Farmers Indirectly Exposed to Pesticides |
title_full | Adverse Health Effects in Women Farmers Indirectly Exposed to Pesticides |
title_fullStr | Adverse Health Effects in Women Farmers Indirectly Exposed to Pesticides |
title_full_unstemmed | Adverse Health Effects in Women Farmers Indirectly Exposed to Pesticides |
title_short | Adverse Health Effects in Women Farmers Indirectly Exposed to Pesticides |
title_sort | adverse health effects in women farmers indirectly exposed to pesticides |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198255/ https://www.ncbi.nlm.nih.gov/pubmed/34072924 http://dx.doi.org/10.3390/ijerph18115909 |
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