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Conductive Hearing Loss with Age—A Histologic and Audiometric Evaluation

A retrospective analysis to quantify age-related changes of the incudo-malleolar joint (IMJ) and incudo-stapedial joint (ISJ), and to analyse changes in the air-bone gap (ABG) with age, was performed. Defined histologic parameters of 153 IMJ and 106 ISJ from subjects aged from birth to 70 years were...

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Autores principales: Dobrev, Ivo, Dillinger, Daniel, Meier, Letizia, Veraguth, Dorothe, Pfiffner, Flurin, Probst, Rudolf, Röösli, Christof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198280/
https://www.ncbi.nlm.nih.gov/pubmed/34071847
http://dx.doi.org/10.3390/jcm10112341
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author Dobrev, Ivo
Dillinger, Daniel
Meier, Letizia
Veraguth, Dorothe
Pfiffner, Flurin
Probst, Rudolf
Röösli, Christof
author_facet Dobrev, Ivo
Dillinger, Daniel
Meier, Letizia
Veraguth, Dorothe
Pfiffner, Flurin
Probst, Rudolf
Röösli, Christof
author_sort Dobrev, Ivo
collection PubMed
description A retrospective analysis to quantify age-related changes of the incudo-malleolar joint (IMJ) and incudo-stapedial joint (ISJ), and to analyse changes in the air-bone gap (ABG) with age, was performed. Defined histologic parameters of 153 IMJ and 106 ISJ from subjects aged from birth to 70 years were correlated to age. Additionally, audiograms of 1760 ears of 974 other subjects aged 20 to 80 years were retrospectively analysed and the ABG was correlated to age. The joint space (age group from 0 to 10 compared to 61 to 70 years) became significantly wider with age (IMJ: from a mean of 44 µm to 100 µm, p < 0.001; ISJ: from a mean of 28 µm to 69 µm, p < 0.009. The thickness of cartilage of the incus decreased in the first 20 years of life (IMJ, from a mean of 88 µm to 65 µm, p < 0.01; ISJ: from a mean of 44 µm to 35 µm, p < 0.01). The ABGs of younger ears (20–40 years) was significantly larger at 500 Hz compared to older ears (60–80 years) by 2–4 dB, while it was significantly smaller by 3–5 dB at 4000 Hz (p < 0.0017). Interindividual variations in all age groups were large for both analyses. The increased joint spaces could potentially reduce the stiffness in the joints and explain the increase in ABG at 4000 Hz and the drop at 500 Hz. While the average change is small and of minimal clinical relevance, a larger increase of ABG with age is seen in some subjects.
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spelling pubmed-81982802021-06-14 Conductive Hearing Loss with Age—A Histologic and Audiometric Evaluation Dobrev, Ivo Dillinger, Daniel Meier, Letizia Veraguth, Dorothe Pfiffner, Flurin Probst, Rudolf Röösli, Christof J Clin Med Article A retrospective analysis to quantify age-related changes of the incudo-malleolar joint (IMJ) and incudo-stapedial joint (ISJ), and to analyse changes in the air-bone gap (ABG) with age, was performed. Defined histologic parameters of 153 IMJ and 106 ISJ from subjects aged from birth to 70 years were correlated to age. Additionally, audiograms of 1760 ears of 974 other subjects aged 20 to 80 years were retrospectively analysed and the ABG was correlated to age. The joint space (age group from 0 to 10 compared to 61 to 70 years) became significantly wider with age (IMJ: from a mean of 44 µm to 100 µm, p < 0.001; ISJ: from a mean of 28 µm to 69 µm, p < 0.009. The thickness of cartilage of the incus decreased in the first 20 years of life (IMJ, from a mean of 88 µm to 65 µm, p < 0.01; ISJ: from a mean of 44 µm to 35 µm, p < 0.01). The ABGs of younger ears (20–40 years) was significantly larger at 500 Hz compared to older ears (60–80 years) by 2–4 dB, while it was significantly smaller by 3–5 dB at 4000 Hz (p < 0.0017). Interindividual variations in all age groups were large for both analyses. The increased joint spaces could potentially reduce the stiffness in the joints and explain the increase in ABG at 4000 Hz and the drop at 500 Hz. While the average change is small and of minimal clinical relevance, a larger increase of ABG with age is seen in some subjects. MDPI 2021-05-27 /pmc/articles/PMC8198280/ /pubmed/34071847 http://dx.doi.org/10.3390/jcm10112341 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dobrev, Ivo
Dillinger, Daniel
Meier, Letizia
Veraguth, Dorothe
Pfiffner, Flurin
Probst, Rudolf
Röösli, Christof
Conductive Hearing Loss with Age—A Histologic and Audiometric Evaluation
title Conductive Hearing Loss with Age—A Histologic and Audiometric Evaluation
title_full Conductive Hearing Loss with Age—A Histologic and Audiometric Evaluation
title_fullStr Conductive Hearing Loss with Age—A Histologic and Audiometric Evaluation
title_full_unstemmed Conductive Hearing Loss with Age—A Histologic and Audiometric Evaluation
title_short Conductive Hearing Loss with Age—A Histologic and Audiometric Evaluation
title_sort conductive hearing loss with age—a histologic and audiometric evaluation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198280/
https://www.ncbi.nlm.nih.gov/pubmed/34071847
http://dx.doi.org/10.3390/jcm10112341
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