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Clinical Outcomes of Pediatric Chronic Intestinal Pseudo-Obstruction
Chronic intestinal pseudo-obstruction (CIPO) is an extremely rare condition with symptoms of recurrent intestinal obstruction without any lesions. The outcomes of pediatric CIPO and predictors for the outcomes have not yet been well established. We analyzed the clinical outcomes and associated facto...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198288/ https://www.ncbi.nlm.nih.gov/pubmed/34071279 http://dx.doi.org/10.3390/jcm10112376 |
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author | Ko, Dayoung Yang, Hee-Beom Youn, Joong Kim, Hyun-Young |
author_facet | Ko, Dayoung Yang, Hee-Beom Youn, Joong Kim, Hyun-Young |
author_sort | Ko, Dayoung |
collection | PubMed |
description | Chronic intestinal pseudo-obstruction (CIPO) is an extremely rare condition with symptoms of recurrent intestinal obstruction without any lesions. The outcomes of pediatric CIPO and predictors for the outcomes have not yet been well established. We analyzed the clinical outcomes and associated factors for the outcomes of pediatric CIPO. We retrospectively reviewed 66 primary CIPO patients diagnosed between January 1985 and December 2017. We evaluated parenteral nutrition (PN) factors such as PN duration, PN use over 6 months, home PN, and mortality as outcomes. We selected onset age, presence of urologic symptoms, pathologic type, and involvement extent as predictors. The early-onset CIPO was found in 63.6%, and 21.2% of the patients presenting with urologic symptoms. Of the 66 patients, 47 and 11 had neuropathy and myopathy, respectively. The generalized involvement type accounted for 83.3% of the cases. At the last follow-up, 24.2% of the patients required home PN management. The mean duration of PN was 11.8 ± 21.0 months. The overall mortality rate of primary CIPO was 18.2%. PN factors were predicted by the urologic symptoms and extent of involvement. However, mortality was predicted by pathologic type. The onset age was not significantly associated with the outcomes. CIPO with urologic symptoms and generalized CIPO had poor PN outcomes. Myopathy is suggested as a predictor of mortality in children with primary CIPO. |
format | Online Article Text |
id | pubmed-8198288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81982882021-06-14 Clinical Outcomes of Pediatric Chronic Intestinal Pseudo-Obstruction Ko, Dayoung Yang, Hee-Beom Youn, Joong Kim, Hyun-Young J Clin Med Article Chronic intestinal pseudo-obstruction (CIPO) is an extremely rare condition with symptoms of recurrent intestinal obstruction without any lesions. The outcomes of pediatric CIPO and predictors for the outcomes have not yet been well established. We analyzed the clinical outcomes and associated factors for the outcomes of pediatric CIPO. We retrospectively reviewed 66 primary CIPO patients diagnosed between January 1985 and December 2017. We evaluated parenteral nutrition (PN) factors such as PN duration, PN use over 6 months, home PN, and mortality as outcomes. We selected onset age, presence of urologic symptoms, pathologic type, and involvement extent as predictors. The early-onset CIPO was found in 63.6%, and 21.2% of the patients presenting with urologic symptoms. Of the 66 patients, 47 and 11 had neuropathy and myopathy, respectively. The generalized involvement type accounted for 83.3% of the cases. At the last follow-up, 24.2% of the patients required home PN management. The mean duration of PN was 11.8 ± 21.0 months. The overall mortality rate of primary CIPO was 18.2%. PN factors were predicted by the urologic symptoms and extent of involvement. However, mortality was predicted by pathologic type. The onset age was not significantly associated with the outcomes. CIPO with urologic symptoms and generalized CIPO had poor PN outcomes. Myopathy is suggested as a predictor of mortality in children with primary CIPO. MDPI 2021-05-28 /pmc/articles/PMC8198288/ /pubmed/34071279 http://dx.doi.org/10.3390/jcm10112376 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ko, Dayoung Yang, Hee-Beom Youn, Joong Kim, Hyun-Young Clinical Outcomes of Pediatric Chronic Intestinal Pseudo-Obstruction |
title | Clinical Outcomes of Pediatric Chronic Intestinal Pseudo-Obstruction |
title_full | Clinical Outcomes of Pediatric Chronic Intestinal Pseudo-Obstruction |
title_fullStr | Clinical Outcomes of Pediatric Chronic Intestinal Pseudo-Obstruction |
title_full_unstemmed | Clinical Outcomes of Pediatric Chronic Intestinal Pseudo-Obstruction |
title_short | Clinical Outcomes of Pediatric Chronic Intestinal Pseudo-Obstruction |
title_sort | clinical outcomes of pediatric chronic intestinal pseudo-obstruction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198288/ https://www.ncbi.nlm.nih.gov/pubmed/34071279 http://dx.doi.org/10.3390/jcm10112376 |
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