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Piperlongumine Analogs Promote A549 Cell Apoptosis through Enhancing ROS Generation

Chemotherapeutic agents, which contain the Michael acceptor, are potent anticancer molecules by promoting intracellular reactive oxygen species (ROS) generation. In this study, we synthesized a panel of PL (piperlongumine) analogs with chlorine attaching at C2 and an electron-withdrawing/electron-do...

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Detalles Bibliográficos
Autores principales:	Sun, Ai-Ling, Mu, Wen-Wen, Li, Yan-Mo, Sun, Ya-Lei, Li, Peng-Xiao, Liu, Ren-Min, Yang, Jie, Liu, Guo-Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198376/ https://www.ncbi.nlm.nih.gov/pubmed/34071298 http://dx.doi.org/10.3390/molecules26113243

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