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Malaria Temporal Variation and Modelling Using Time-Series in Sussundenga District, Mozambique
Malaria is one of the leading causes of morbidity and mortality in Mozambique, which has the fifth highest prevalence in the world. Sussundenga District in Manica Province has documented high P. falciparum incidence at the local rural health center (RHC). This study’s objective was to analyze the P....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198511/ https://www.ncbi.nlm.nih.gov/pubmed/34073319 http://dx.doi.org/10.3390/ijerph18115692 |
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author | Ferrão, João L. Earland, Dominique Novela, Anísio Mendes, Roberto Tungadza, Alberto Searle, Kelly M. |
author_facet | Ferrão, João L. Earland, Dominique Novela, Anísio Mendes, Roberto Tungadza, Alberto Searle, Kelly M. |
author_sort | Ferrão, João L. |
collection | PubMed |
description | Malaria is one of the leading causes of morbidity and mortality in Mozambique, which has the fifth highest prevalence in the world. Sussundenga District in Manica Province has documented high P. falciparum incidence at the local rural health center (RHC). This study’s objective was to analyze the P. falciparum temporal variation and model its pattern in Sussundenga District, Mozambique. Data from weekly epidemiological bulletins (BES) was collected from 2015 to 2019 and a time-series analysis was applied. For temporal modeling, a Box-Jenkins method was used with an autoregressive integrated moving average (ARIMA). Over the study period, 372,498 cases of P. falciparum were recorded in Sussundenga. There were weekly and yearly variations in incidence overall (p < 0.001). Children under five years had decreased malaria tendency, while patients over five years had an increased tendency. The ARIMA (2,2,1) (1,1,1) (52) model presented the least Root Mean Square being the most appropriate for forecasting. The goodness of fit was 68.15% for malaria patients less than five years old and 73.2% for malaria patients over five years old. The findings indicate that cases are decreasing among individuals less than five years and are increasing slightly in those older than five years. The P. falciparum case occurrence has a weekly temporal pattern peaking during the wet season. Based on the spatial and temporal distribution using ARIMA modelling, more efficient strategies that target this seasonality can be implemented to reduce the overall malaria burden in both Sussundenga District and regionally. |
format | Online Article Text |
id | pubmed-8198511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81985112021-06-14 Malaria Temporal Variation and Modelling Using Time-Series in Sussundenga District, Mozambique Ferrão, João L. Earland, Dominique Novela, Anísio Mendes, Roberto Tungadza, Alberto Searle, Kelly M. Int J Environ Res Public Health Article Malaria is one of the leading causes of morbidity and mortality in Mozambique, which has the fifth highest prevalence in the world. Sussundenga District in Manica Province has documented high P. falciparum incidence at the local rural health center (RHC). This study’s objective was to analyze the P. falciparum temporal variation and model its pattern in Sussundenga District, Mozambique. Data from weekly epidemiological bulletins (BES) was collected from 2015 to 2019 and a time-series analysis was applied. For temporal modeling, a Box-Jenkins method was used with an autoregressive integrated moving average (ARIMA). Over the study period, 372,498 cases of P. falciparum were recorded in Sussundenga. There were weekly and yearly variations in incidence overall (p < 0.001). Children under five years had decreased malaria tendency, while patients over five years had an increased tendency. The ARIMA (2,2,1) (1,1,1) (52) model presented the least Root Mean Square being the most appropriate for forecasting. The goodness of fit was 68.15% for malaria patients less than five years old and 73.2% for malaria patients over five years old. The findings indicate that cases are decreasing among individuals less than five years and are increasing slightly in those older than five years. The P. falciparum case occurrence has a weekly temporal pattern peaking during the wet season. Based on the spatial and temporal distribution using ARIMA modelling, more efficient strategies that target this seasonality can be implemented to reduce the overall malaria burden in both Sussundenga District and regionally. MDPI 2021-05-26 /pmc/articles/PMC8198511/ /pubmed/34073319 http://dx.doi.org/10.3390/ijerph18115692 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ferrão, João L. Earland, Dominique Novela, Anísio Mendes, Roberto Tungadza, Alberto Searle, Kelly M. Malaria Temporal Variation and Modelling Using Time-Series in Sussundenga District, Mozambique |
title | Malaria Temporal Variation and Modelling Using Time-Series in Sussundenga District, Mozambique |
title_full | Malaria Temporal Variation and Modelling Using Time-Series in Sussundenga District, Mozambique |
title_fullStr | Malaria Temporal Variation and Modelling Using Time-Series in Sussundenga District, Mozambique |
title_full_unstemmed | Malaria Temporal Variation and Modelling Using Time-Series in Sussundenga District, Mozambique |
title_short | Malaria Temporal Variation and Modelling Using Time-Series in Sussundenga District, Mozambique |
title_sort | malaria temporal variation and modelling using time-series in sussundenga district, mozambique |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198511/ https://www.ncbi.nlm.nih.gov/pubmed/34073319 http://dx.doi.org/10.3390/ijerph18115692 |
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