Supramolecular Chromatographic Separation of C(60) and C(70) Fullerenes: Flash Column Chromatography vs. High Pressure Liquid Chromatography

A silica-bound C-butylpyrogallol[4]arene chromatographic stationary phase was prepared and characterised by thermogravimetric analysis, scanning electron microscopy, NMR and mass spectrometry. The chromatographic performance was investigated by using C(60) and C(70) fullerenes in reverse phase mode...

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Detalles Bibliográficos
Autores principales: Mekapothula, Subbareddy, Wonanke, A. D. Dinga, Addicoat, Matthew A., Boocock, David J., Wallis, John D., Cave, Gareth W. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198677/
https://www.ncbi.nlm.nih.gov/pubmed/34072234
http://dx.doi.org/10.3390/ijms22115726
Descripción
Sumario:A silica-bound C-butylpyrogallol[4]arene chromatographic stationary phase was prepared and characterised by thermogravimetric analysis, scanning electron microscopy, NMR and mass spectrometry. The chromatographic performance was investigated by using C(60) and C(70) fullerenes in reverse phase mode via flash column and high-pressure liquid chromatography (HPLC). The resulting new stationary phase was observed to demonstrate size-selective molecular recognition as postulated from our in-silico studies. The silica-bound C-butylpyrogallol[4]arene flash and HPLC stationary phases were able to separate a C(60)- and C(70)-fullerene mixture more effectively than an RP-C(18) stationary phase. The presence of toluene in the mobile phase plays a significant role in achieving symmetrical peaks in flash column chromatography.

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