The Multifaceted Nature of Nucleobindin-2 in Carcinogenesis

Nucb2 is a multifunctional protein associated with a variety of biological processes. Multiple studies have revealed that Nucb2, and its derivative nesfatin-1, are involved in carcinogenesis. Interestingly, the role of Nucb2/nesfatin-1 in tumorigenesis seems to be dual—both pro-metastatic and anti-m...

Descripción completa

Detalles Bibliográficos
Autores principales: Skorupska, Anna, Lenda, Rafał, Ożyhar, Andrzej, Bystranowska, Dominika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198689/
https://www.ncbi.nlm.nih.gov/pubmed/34073612
http://dx.doi.org/10.3390/ijms22115687
_version_ 1783707198957813760
author Skorupska, Anna
Lenda, Rafał
Ożyhar, Andrzej
Bystranowska, Dominika
author_facet Skorupska, Anna
Lenda, Rafał
Ożyhar, Andrzej
Bystranowska, Dominika
author_sort Skorupska, Anna
collection PubMed
description Nucb2 is a multifunctional protein associated with a variety of biological processes. Multiple studies have revealed that Nucb2, and its derivative nesfatin-1, are involved in carcinogenesis. Interestingly, the role of Nucb2/nesfatin-1 in tumorigenesis seems to be dual—both pro-metastatic and anti-metastatic. The implication of Nucb2/nesfatin-1 in carcinogenesis seems to be tissue dependent. Herein, we review the role of Nucb2/nesfatin-1 in both carcinogenesis and the apoptosis process, and we also highlight the multifaceted nature of Nucb2/nesfatin-1.
format Online
Article
Text
id pubmed-8198689
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-81986892021-06-14 The Multifaceted Nature of Nucleobindin-2 in Carcinogenesis Skorupska, Anna Lenda, Rafał Ożyhar, Andrzej Bystranowska, Dominika Int J Mol Sci Review Nucb2 is a multifunctional protein associated with a variety of biological processes. Multiple studies have revealed that Nucb2, and its derivative nesfatin-1, are involved in carcinogenesis. Interestingly, the role of Nucb2/nesfatin-1 in tumorigenesis seems to be dual—both pro-metastatic and anti-metastatic. The implication of Nucb2/nesfatin-1 in carcinogenesis seems to be tissue dependent. Herein, we review the role of Nucb2/nesfatin-1 in both carcinogenesis and the apoptosis process, and we also highlight the multifaceted nature of Nucb2/nesfatin-1. MDPI 2021-05-26 /pmc/articles/PMC8198689/ /pubmed/34073612 http://dx.doi.org/10.3390/ijms22115687 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Skorupska, Anna
Lenda, Rafał
Ożyhar, Andrzej
Bystranowska, Dominika
The Multifaceted Nature of Nucleobindin-2 in Carcinogenesis
title The Multifaceted Nature of Nucleobindin-2 in Carcinogenesis
title_full The Multifaceted Nature of Nucleobindin-2 in Carcinogenesis
title_fullStr The Multifaceted Nature of Nucleobindin-2 in Carcinogenesis
title_full_unstemmed The Multifaceted Nature of Nucleobindin-2 in Carcinogenesis
title_short The Multifaceted Nature of Nucleobindin-2 in Carcinogenesis
title_sort multifaceted nature of nucleobindin-2 in carcinogenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198689/
https://www.ncbi.nlm.nih.gov/pubmed/34073612
http://dx.doi.org/10.3390/ijms22115687
work_keys_str_mv AT skorupskaanna themultifacetednatureofnucleobindin2incarcinogenesis
AT lendarafał themultifacetednatureofnucleobindin2incarcinogenesis
AT ozyharandrzej themultifacetednatureofnucleobindin2incarcinogenesis
AT bystranowskadominika themultifacetednatureofnucleobindin2incarcinogenesis
AT skorupskaanna multifacetednatureofnucleobindin2incarcinogenesis
AT lendarafał multifacetednatureofnucleobindin2incarcinogenesis
AT ozyharandrzej multifacetednatureofnucleobindin2incarcinogenesis
AT bystranowskadominika multifacetednatureofnucleobindin2incarcinogenesis

Ejemplares similares