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Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System
Rapid growth of the geriatric population has been made possible with advancements in pharmaceutical and health sciences. Hence, age-associated diseases are becoming more common. Aging encompasses deterioration of the immune system, known as immunosenescence. Dysregulation of the immune cell producti...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198707/ https://www.ncbi.nlm.nih.gov/pubmed/34072224 http://dx.doi.org/10.3390/ijms22115749 |
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author | Yeo, Genieve Ee Chia Ng, Min Hwei Nordin, Fazlina Binti Law, Jia Xian |
author_facet | Yeo, Genieve Ee Chia Ng, Min Hwei Nordin, Fazlina Binti Law, Jia Xian |
author_sort | Yeo, Genieve Ee Chia |
collection | PubMed |
description | Rapid growth of the geriatric population has been made possible with advancements in pharmaceutical and health sciences. Hence, age-associated diseases are becoming more common. Aging encompasses deterioration of the immune system, known as immunosenescence. Dysregulation of the immune cell production, differentiation, and functioning lead to a chronic subclinical inflammatory state termed inflammaging. The hallmarks of the aging immune system are decreased naïve cells, increased memory cells, and increased serum levels of pro-inflammatory cytokines. Mesenchymal stem cell (MSC) transplantation is a promising solution to halt immunosenescence as the cells have excellent immunomodulatory functions and low immunogenicity. This review compiles the present knowledge of the causes and changes of the aging immune system and the potential of MSC transplantation as a regenerative therapy for immunosenescence. |
format | Online Article Text |
id | pubmed-8198707 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81987072021-06-14 Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System Yeo, Genieve Ee Chia Ng, Min Hwei Nordin, Fazlina Binti Law, Jia Xian Int J Mol Sci Review Rapid growth of the geriatric population has been made possible with advancements in pharmaceutical and health sciences. Hence, age-associated diseases are becoming more common. Aging encompasses deterioration of the immune system, known as immunosenescence. Dysregulation of the immune cell production, differentiation, and functioning lead to a chronic subclinical inflammatory state termed inflammaging. The hallmarks of the aging immune system are decreased naïve cells, increased memory cells, and increased serum levels of pro-inflammatory cytokines. Mesenchymal stem cell (MSC) transplantation is a promising solution to halt immunosenescence as the cells have excellent immunomodulatory functions and low immunogenicity. This review compiles the present knowledge of the causes and changes of the aging immune system and the potential of MSC transplantation as a regenerative therapy for immunosenescence. MDPI 2021-05-27 /pmc/articles/PMC8198707/ /pubmed/34072224 http://dx.doi.org/10.3390/ijms22115749 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yeo, Genieve Ee Chia Ng, Min Hwei Nordin, Fazlina Binti Law, Jia Xian Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System |
title | Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System |
title_full | Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System |
title_fullStr | Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System |
title_full_unstemmed | Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System |
title_short | Potential of Mesenchymal Stem Cells in the Rejuvenation of the Aging Immune System |
title_sort | potential of mesenchymal stem cells in the rejuvenation of the aging immune system |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198707/ https://www.ncbi.nlm.nih.gov/pubmed/34072224 http://dx.doi.org/10.3390/ijms22115749 |
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