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Comparison of Non-Tumoral Portal Vein Thrombosis Management in Cirrhotic Patients: TIPS Versus Anticoagulation Versus No Treatment
Background: There is a lack of consensus in optimal management of portal vein thrombosis (PVT) in patients with cirrhosis. The purpose of this study is to compare the safety and thrombosis burden change for cirrhotic patients with non-tumoral PVT managed by transjugular intrahepatic portosystemic sh...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198761/ https://www.ncbi.nlm.nih.gov/pubmed/34073236 http://dx.doi.org/10.3390/jcm10112316 |
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author | Zhan, Chenyang Prabhu, Vinay Kang, Stella K. Li, Clayton Zhu, Yuli Kim, Sooah Olsen, Sonja Jacobson, Ira M. Dagher, Nabil N. Carney, Brendan Hickey, Ryan M. Taslakian, Bedros |
author_facet | Zhan, Chenyang Prabhu, Vinay Kang, Stella K. Li, Clayton Zhu, Yuli Kim, Sooah Olsen, Sonja Jacobson, Ira M. Dagher, Nabil N. Carney, Brendan Hickey, Ryan M. Taslakian, Bedros |
author_sort | Zhan, Chenyang |
collection | PubMed |
description | Background: There is a lack of consensus in optimal management of portal vein thrombosis (PVT) in patients with cirrhosis. The purpose of this study is to compare the safety and thrombosis burden change for cirrhotic patients with non-tumoral PVT managed by transjugular intrahepatic portosystemic shunt (TIPS) only, anticoagulation only, or no treatment. Methods: This single-center retrospective study evaluated 52 patients with cirrhosis and non-tumoral PVT managed by TIPS only (14), anticoagulation only (11), or no treatment (27). The demographic, clinical, and imaging data for patients were collected. The portomesenteric thrombosis burden and liver function tests at early follow-up (6–9 months) and late follow-up (9–16 months) were compared to the baseline. Adverse events including bleeding and encephalopathy were recorded. Results: The overall portomesenteric thrombosis burden improved in eight (72%) TIPS patients, three (27%) anticoagulated patients, and two (10%) untreated patients at early follow-up (p = 0.001) and in seven (78%) TIPS patients, two (29%) anticoagulated patients, and three (17%) untreated patients in late follow-up (p = 0.007). No bleeding complications attributable to anticoagulation were observed. Conclusion: TIPS decreased portomesenteric thrombus burden compared to anticoagulation or no treatment for cirrhotic patients with PVT. Both TIPS and anticoagulation were safe therapies. |
format | Online Article Text |
id | pubmed-8198761 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81987612021-06-14 Comparison of Non-Tumoral Portal Vein Thrombosis Management in Cirrhotic Patients: TIPS Versus Anticoagulation Versus No Treatment Zhan, Chenyang Prabhu, Vinay Kang, Stella K. Li, Clayton Zhu, Yuli Kim, Sooah Olsen, Sonja Jacobson, Ira M. Dagher, Nabil N. Carney, Brendan Hickey, Ryan M. Taslakian, Bedros J Clin Med Article Background: There is a lack of consensus in optimal management of portal vein thrombosis (PVT) in patients with cirrhosis. The purpose of this study is to compare the safety and thrombosis burden change for cirrhotic patients with non-tumoral PVT managed by transjugular intrahepatic portosystemic shunt (TIPS) only, anticoagulation only, or no treatment. Methods: This single-center retrospective study evaluated 52 patients with cirrhosis and non-tumoral PVT managed by TIPS only (14), anticoagulation only (11), or no treatment (27). The demographic, clinical, and imaging data for patients were collected. The portomesenteric thrombosis burden and liver function tests at early follow-up (6–9 months) and late follow-up (9–16 months) were compared to the baseline. Adverse events including bleeding and encephalopathy were recorded. Results: The overall portomesenteric thrombosis burden improved in eight (72%) TIPS patients, three (27%) anticoagulated patients, and two (10%) untreated patients at early follow-up (p = 0.001) and in seven (78%) TIPS patients, two (29%) anticoagulated patients, and three (17%) untreated patients in late follow-up (p = 0.007). No bleeding complications attributable to anticoagulation were observed. Conclusion: TIPS decreased portomesenteric thrombus burden compared to anticoagulation or no treatment for cirrhotic patients with PVT. Both TIPS and anticoagulation were safe therapies. MDPI 2021-05-26 /pmc/articles/PMC8198761/ /pubmed/34073236 http://dx.doi.org/10.3390/jcm10112316 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhan, Chenyang Prabhu, Vinay Kang, Stella K. Li, Clayton Zhu, Yuli Kim, Sooah Olsen, Sonja Jacobson, Ira M. Dagher, Nabil N. Carney, Brendan Hickey, Ryan M. Taslakian, Bedros Comparison of Non-Tumoral Portal Vein Thrombosis Management in Cirrhotic Patients: TIPS Versus Anticoagulation Versus No Treatment |
title | Comparison of Non-Tumoral Portal Vein Thrombosis Management in Cirrhotic Patients: TIPS Versus Anticoagulation Versus No Treatment |
title_full | Comparison of Non-Tumoral Portal Vein Thrombosis Management in Cirrhotic Patients: TIPS Versus Anticoagulation Versus No Treatment |
title_fullStr | Comparison of Non-Tumoral Portal Vein Thrombosis Management in Cirrhotic Patients: TIPS Versus Anticoagulation Versus No Treatment |
title_full_unstemmed | Comparison of Non-Tumoral Portal Vein Thrombosis Management in Cirrhotic Patients: TIPS Versus Anticoagulation Versus No Treatment |
title_short | Comparison of Non-Tumoral Portal Vein Thrombosis Management in Cirrhotic Patients: TIPS Versus Anticoagulation Versus No Treatment |
title_sort | comparison of non-tumoral portal vein thrombosis management in cirrhotic patients: tips versus anticoagulation versus no treatment |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198761/ https://www.ncbi.nlm.nih.gov/pubmed/34073236 http://dx.doi.org/10.3390/jcm10112316 |
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