Cargando…
Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6
Dietary phenolic compounds possess potent bioactivity against inflammatory pathways of chronic inflammatory conditions, such as type 2 diabetes. Here, the phenolic profile and bioactivity of Italian red wines Gaglioppo, Magliocco, and Nerello Mascalese were characterized. NMR, HPLC/UV-Vis and spectr...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198779/ https://www.ncbi.nlm.nih.gov/pubmed/34073604 http://dx.doi.org/10.3390/ijms22115677 |
_version_ | 1783707220009025536 |
---|---|
author | D’Onofrio, Nunzia Martino, Elisa Chianese, Giuseppina Coppola, Francesca Picariello, Luigi Moio, Luigi Balestrieri, Maria Luisa Gambuti, Angelita Forino, Martino |
author_facet | D’Onofrio, Nunzia Martino, Elisa Chianese, Giuseppina Coppola, Francesca Picariello, Luigi Moio, Luigi Balestrieri, Maria Luisa Gambuti, Angelita Forino, Martino |
author_sort | D’Onofrio, Nunzia |
collection | PubMed |
description | Dietary phenolic compounds possess potent bioactivity against inflammatory pathways of chronic inflammatory conditions, such as type 2 diabetes. Here, the phenolic profile and bioactivity of Italian red wines Gaglioppo, Magliocco, and Nerello Mascalese were characterized. NMR, HPLC/UV-Vis and spectrophotometric characterization showed that Magliocco was the richest wine in monomeric anthocyanins (two-fold), catechins, and low molecular weight phenolics (LMWP). A positive correlation was observed between the polyphenolic content and antioxidant capacity (p < 0.05), with Magliocco displaying the highest antioxidant capacity (p < 0.01). In vitro evidence on the endothelial cell models of insulin resistance and hyperglycemia showed the ability of Magliocco to reduce reactive oxygen species (ROS) (p < 0.01) and cytokine release (p < 0.01) and to upregulate SIRT1 and SIRT6 (p < 0.01). On the whole, the results indicated that the quantitative and qualitative phenolic profiles of red wines influence their in vitro beneficial effects on oxidative and proinflammatory milieu in endothelial cells, showing a positive modulation of SIRT1 and SIRT6, both implied in vascular aging. |
format | Online Article Text |
id | pubmed-8198779 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81987792021-06-14 Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6 D’Onofrio, Nunzia Martino, Elisa Chianese, Giuseppina Coppola, Francesca Picariello, Luigi Moio, Luigi Balestrieri, Maria Luisa Gambuti, Angelita Forino, Martino Int J Mol Sci Article Dietary phenolic compounds possess potent bioactivity against inflammatory pathways of chronic inflammatory conditions, such as type 2 diabetes. Here, the phenolic profile and bioactivity of Italian red wines Gaglioppo, Magliocco, and Nerello Mascalese were characterized. NMR, HPLC/UV-Vis and spectrophotometric characterization showed that Magliocco was the richest wine in monomeric anthocyanins (two-fold), catechins, and low molecular weight phenolics (LMWP). A positive correlation was observed between the polyphenolic content and antioxidant capacity (p < 0.05), with Magliocco displaying the highest antioxidant capacity (p < 0.01). In vitro evidence on the endothelial cell models of insulin resistance and hyperglycemia showed the ability of Magliocco to reduce reactive oxygen species (ROS) (p < 0.01) and cytokine release (p < 0.01) and to upregulate SIRT1 and SIRT6 (p < 0.01). On the whole, the results indicated that the quantitative and qualitative phenolic profiles of red wines influence their in vitro beneficial effects on oxidative and proinflammatory milieu in endothelial cells, showing a positive modulation of SIRT1 and SIRT6, both implied in vascular aging. MDPI 2021-05-26 /pmc/articles/PMC8198779/ /pubmed/34073604 http://dx.doi.org/10.3390/ijms22115677 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article D’Onofrio, Nunzia Martino, Elisa Chianese, Giuseppina Coppola, Francesca Picariello, Luigi Moio, Luigi Balestrieri, Maria Luisa Gambuti, Angelita Forino, Martino Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6 |
title | Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6 |
title_full | Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6 |
title_fullStr | Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6 |
title_full_unstemmed | Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6 |
title_short | Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6 |
title_sort | phenolic profiles of red wine relate to vascular endothelial benefits mediated by sirt1 and sirt6 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198779/ https://www.ncbi.nlm.nih.gov/pubmed/34073604 http://dx.doi.org/10.3390/ijms22115677 |
work_keys_str_mv | AT donofrionunzia phenolicprofilesofredwinerelatetovascularendothelialbenefitsmediatedbysirt1andsirt6 AT martinoelisa phenolicprofilesofredwinerelatetovascularendothelialbenefitsmediatedbysirt1andsirt6 AT chianesegiuseppina phenolicprofilesofredwinerelatetovascularendothelialbenefitsmediatedbysirt1andsirt6 AT coppolafrancesca phenolicprofilesofredwinerelatetovascularendothelialbenefitsmediatedbysirt1andsirt6 AT picarielloluigi phenolicprofilesofredwinerelatetovascularendothelialbenefitsmediatedbysirt1andsirt6 AT moioluigi phenolicprofilesofredwinerelatetovascularendothelialbenefitsmediatedbysirt1andsirt6 AT balestrierimarialuisa phenolicprofilesofredwinerelatetovascularendothelialbenefitsmediatedbysirt1andsirt6 AT gambutiangelita phenolicprofilesofredwinerelatetovascularendothelialbenefitsmediatedbysirt1andsirt6 AT forinomartino phenolicprofilesofredwinerelatetovascularendothelialbenefitsmediatedbysirt1andsirt6 |