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Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6

Dietary phenolic compounds possess potent bioactivity against inflammatory pathways of chronic inflammatory conditions, such as type 2 diabetes. Here, the phenolic profile and bioactivity of Italian red wines Gaglioppo, Magliocco, and Nerello Mascalese were characterized. NMR, HPLC/UV-Vis and spectr...

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Autores principales: D’Onofrio, Nunzia, Martino, Elisa, Chianese, Giuseppina, Coppola, Francesca, Picariello, Luigi, Moio, Luigi, Balestrieri, Maria Luisa, Gambuti, Angelita, Forino, Martino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198779/
https://www.ncbi.nlm.nih.gov/pubmed/34073604
http://dx.doi.org/10.3390/ijms22115677
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author D’Onofrio, Nunzia
Martino, Elisa
Chianese, Giuseppina
Coppola, Francesca
Picariello, Luigi
Moio, Luigi
Balestrieri, Maria Luisa
Gambuti, Angelita
Forino, Martino
author_facet D’Onofrio, Nunzia
Martino, Elisa
Chianese, Giuseppina
Coppola, Francesca
Picariello, Luigi
Moio, Luigi
Balestrieri, Maria Luisa
Gambuti, Angelita
Forino, Martino
author_sort D’Onofrio, Nunzia
collection PubMed
description Dietary phenolic compounds possess potent bioactivity against inflammatory pathways of chronic inflammatory conditions, such as type 2 diabetes. Here, the phenolic profile and bioactivity of Italian red wines Gaglioppo, Magliocco, and Nerello Mascalese were characterized. NMR, HPLC/UV-Vis and spectrophotometric characterization showed that Magliocco was the richest wine in monomeric anthocyanins (two-fold), catechins, and low molecular weight phenolics (LMWP). A positive correlation was observed between the polyphenolic content and antioxidant capacity (p < 0.05), with Magliocco displaying the highest antioxidant capacity (p < 0.01). In vitro evidence on the endothelial cell models of insulin resistance and hyperglycemia showed the ability of Magliocco to reduce reactive oxygen species (ROS) (p < 0.01) and cytokine release (p < 0.01) and to upregulate SIRT1 and SIRT6 (p < 0.01). On the whole, the results indicated that the quantitative and qualitative phenolic profiles of red wines influence their in vitro beneficial effects on oxidative and proinflammatory milieu in endothelial cells, showing a positive modulation of SIRT1 and SIRT6, both implied in vascular aging.
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spelling pubmed-81987792021-06-14 Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6 D’Onofrio, Nunzia Martino, Elisa Chianese, Giuseppina Coppola, Francesca Picariello, Luigi Moio, Luigi Balestrieri, Maria Luisa Gambuti, Angelita Forino, Martino Int J Mol Sci Article Dietary phenolic compounds possess potent bioactivity against inflammatory pathways of chronic inflammatory conditions, such as type 2 diabetes. Here, the phenolic profile and bioactivity of Italian red wines Gaglioppo, Magliocco, and Nerello Mascalese were characterized. NMR, HPLC/UV-Vis and spectrophotometric characterization showed that Magliocco was the richest wine in monomeric anthocyanins (two-fold), catechins, and low molecular weight phenolics (LMWP). A positive correlation was observed between the polyphenolic content and antioxidant capacity (p < 0.05), with Magliocco displaying the highest antioxidant capacity (p < 0.01). In vitro evidence on the endothelial cell models of insulin resistance and hyperglycemia showed the ability of Magliocco to reduce reactive oxygen species (ROS) (p < 0.01) and cytokine release (p < 0.01) and to upregulate SIRT1 and SIRT6 (p < 0.01). On the whole, the results indicated that the quantitative and qualitative phenolic profiles of red wines influence their in vitro beneficial effects on oxidative and proinflammatory milieu in endothelial cells, showing a positive modulation of SIRT1 and SIRT6, both implied in vascular aging. MDPI 2021-05-26 /pmc/articles/PMC8198779/ /pubmed/34073604 http://dx.doi.org/10.3390/ijms22115677 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
D’Onofrio, Nunzia
Martino, Elisa
Chianese, Giuseppina
Coppola, Francesca
Picariello, Luigi
Moio, Luigi
Balestrieri, Maria Luisa
Gambuti, Angelita
Forino, Martino
Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6
title Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6
title_full Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6
title_fullStr Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6
title_full_unstemmed Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6
title_short Phenolic Profiles of Red Wine Relate to Vascular Endothelial Benefits Mediated by SIRT1 and SIRT6
title_sort phenolic profiles of red wine relate to vascular endothelial benefits mediated by sirt1 and sirt6
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198779/
https://www.ncbi.nlm.nih.gov/pubmed/34073604
http://dx.doi.org/10.3390/ijms22115677
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