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Application of Halloysite Nanotubes in Cancer Therapy—A Review

Halloysite, a nanoclay characterized by a unique, tubular structure, with oppositely charged interior and exterior, suitable, nanometric-range size, high biocompatibility, and low cost, is recently gaining more and more interest as an important and versatile component of various biomaterials and del...

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Autores principales: Karewicz, Anna, Machowska, Adrianna, Kasprzyk, Martyna, Ledwójcik, Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198791/
https://www.ncbi.nlm.nih.gov/pubmed/34072513
http://dx.doi.org/10.3390/ma14112943
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author Karewicz, Anna
Machowska, Adrianna
Kasprzyk, Martyna
Ledwójcik, Gabriela
author_facet Karewicz, Anna
Machowska, Adrianna
Kasprzyk, Martyna
Ledwójcik, Gabriela
author_sort Karewicz, Anna
collection PubMed
description Halloysite, a nanoclay characterized by a unique, tubular structure, with oppositely charged interior and exterior, suitable, nanometric-range size, high biocompatibility, and low cost, is recently gaining more and more interest as an important and versatile component of various biomaterials and delivery systems of biomedical relevance. One of the most recent, significant, and intensely studied fields in which halloysite nanotubes (HNTs) found diverse applications is cancer therapy. Even though this particular direction is mentioned in several more general reviews, it has never so far been discussed in detail. In our review, we offer an extended survey of the literature on that particular aspect of the biomedical application of HNTs. While historical perspective is also given, our paper is focused on the most recent developments in this field, including controlled delivery and release of anticancer agents and nucleic acids by HNT-based systems, targeting cancer cells using HNT as a carrier, and the capture and analysis of circulating tumor cells (CTCs) with nanostructured or magnetic HNT surfaces. The overview of the most up-to-date knowledge on the HNT interactions with cancer cells is also given.
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spelling pubmed-81987912021-06-14 Application of Halloysite Nanotubes in Cancer Therapy—A Review Karewicz, Anna Machowska, Adrianna Kasprzyk, Martyna Ledwójcik, Gabriela Materials (Basel) Review Halloysite, a nanoclay characterized by a unique, tubular structure, with oppositely charged interior and exterior, suitable, nanometric-range size, high biocompatibility, and low cost, is recently gaining more and more interest as an important and versatile component of various biomaterials and delivery systems of biomedical relevance. One of the most recent, significant, and intensely studied fields in which halloysite nanotubes (HNTs) found diverse applications is cancer therapy. Even though this particular direction is mentioned in several more general reviews, it has never so far been discussed in detail. In our review, we offer an extended survey of the literature on that particular aspect of the biomedical application of HNTs. While historical perspective is also given, our paper is focused on the most recent developments in this field, including controlled delivery and release of anticancer agents and nucleic acids by HNT-based systems, targeting cancer cells using HNT as a carrier, and the capture and analysis of circulating tumor cells (CTCs) with nanostructured or magnetic HNT surfaces. The overview of the most up-to-date knowledge on the HNT interactions with cancer cells is also given. MDPI 2021-05-29 /pmc/articles/PMC8198791/ /pubmed/34072513 http://dx.doi.org/10.3390/ma14112943 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Karewicz, Anna
Machowska, Adrianna
Kasprzyk, Martyna
Ledwójcik, Gabriela
Application of Halloysite Nanotubes in Cancer Therapy—A Review
title Application of Halloysite Nanotubes in Cancer Therapy—A Review
title_full Application of Halloysite Nanotubes in Cancer Therapy—A Review
title_fullStr Application of Halloysite Nanotubes in Cancer Therapy—A Review
title_full_unstemmed Application of Halloysite Nanotubes in Cancer Therapy—A Review
title_short Application of Halloysite Nanotubes in Cancer Therapy—A Review
title_sort application of halloysite nanotubes in cancer therapy—a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198791/
https://www.ncbi.nlm.nih.gov/pubmed/34072513
http://dx.doi.org/10.3390/ma14112943
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