Cargando…

Circumventing Drug Treatment? Intrinsic Lethal Effects of Polyethyleneimine (PEI)-Functionalized Nanoparticles on Glioblastoma Cells Cultured in Stem Cell Conditions

SIMPLE SUMMARY: Glioblastoma (GB) is the most frequent brain cancer that is highly difficult to treat. As with many cancer types, associated cancer stem cells can act as a reservoir of cancer-initiating cells, constituting a major hurdle for successful therapy. Herein, we report on a discovery of th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Prabhakar, Neeraj, Merisaari, Joni, Le Joncour, Vadim, Peurla, Markus, Karaman, Didem Şen, Casals, Eudald, Laakkonen, Pirjo, Westermarck, Jukka, Rosenholm, Jessica M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198814/ https://www.ncbi.nlm.nih.gov/pubmed/34071918 http://dx.doi.org/10.3390/cancers13112631

Ejemplares similares

Stimuli-responsive hybrid nanocarriers developed by controllable integration of hyperbranched PEI with mesoporous silica nanoparticles for sustained intracellular siRNA delivery
por: Prabhakar, Neeraj, et al.
Publicado: (2016)

Monotherapy efficacy of blood–brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma
por: Merisaari, Joni, et al.
Publicado: (2020)

Targeted modulation of cell differentiation in distinct regions of the gastrointestinal tract via oral administration of differently PEG-PEI functionalized mesoporous silica nanoparticles
por: Desai, Diti, et al.
Publicado: (2016)

Fluorescent and Electron-Dense Green Color Emitting Nanodiamonds for Single-Cell Correlative Microscopy
por: Prabhakar, Neeraj, et al.
Publicado: (2020)

Polyethyleneimine (PEI) as a Polymer-Based Co-Delivery System for Breast Cancer Therapy
por: Fahira, Alistia Ilmiah, et al.
Publicado: (2022)

Stabilization of Candida antarctica Lipase B (CALB) Immobilized on Octyl Agarose by Treatment with Polyethyleneimine (PEI)
por: Peirce, Sara, et al.
Publicado: (2016)

Immobilization of Polyethyleneimine (PEI) on Flat Surfaces and Nanoparticles Affects Its Ability to Disrupt Bacterial Membranes
por: Andoy, Nesha May Octavio, et al.
Publicado: (2021)

Polyethyleneimine (PEI) Mediated siRNA Gene Silencing in the Schistosoma mansoni Snail Host, Biomphalaria glabrata
por: Knight, Matty, et al.
Publicado: (2011)

Circumventing Zygotic Lethality to Generate Maternal Mutants in Zebrafish
por: Shi, De-Li
Publicado: (2022)

Gene expression analyses of primary melanomas reveal CTHRC1 as an important player in melanoma progression
por: Eriksson, Johanna, et al.
Publicado: (2016)

Intracellular Trafficking of Fluorescent Nanodiamonds and Regulation of Their Cellular Toxicity
por: Prabhakar, Neeraj, et al.
Publicado: (2017)

Prolyl 4‐hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls
por: Eriksson, Johanna, et al.
Publicado: (2020)

N-Heterocyclic Carbene-Polyethyleneimine (PEI) Platinum Complexes Inducing Human Cancer Cell Death: Polymer Carrier Impact
por: Wantz, May, et al.
Publicado: (2018)

Cell Volume (3D) Correlative Microscopy Facilitated by Intracellular Fluorescent Nanodiamonds as Multi-Modal Probes
por: Prabhakar, Neeraj, et al.
Publicado: (2020)

(2S, 4R)-4-[(18)F]Fluoroglutamine for In vivo PET Imaging of Glioma Xenografts in Mice: an Evaluation of Multiple Pharmacokinetic Models
por: Miner, Maxwell WG, et al.
Publicado: (2020)

Characterization of modified mesoporous silica nanoparticles as vectors for siRNA delivery
por: Slita, Anna, et al.
Publicado: (2018)

The effects of transfection reagent polyethyleneimine (PEI) and non-targeting control siRNAs on global gene expression in human aortic smooth muscle cells
por: Raof, Nurazhani A., et al.
Publicado: (2016)

Cationic Polyethyleneimine (PEI)–Gold Nanocomposites Modulate Macrophage Activation and Reprogram Mouse Breast Triple-Negative MET-1 Tumor Immunological Microenvironment
por: Mulens-Arias, Vladimir, et al.
Publicado: (2022)

Analyses in zebrafish embryos reveal that nanotoxicity profiles are dependent on surface-functionalization controlled penetrance of biological membranes
por: Paatero, Ilkka, et al.
Publicado: (2017)

Bivalent EGFR-Targeting DARPin-MMAE Conjugates
por: Karsten, Lennard, et al.
Publicado: (2022)

CD109-GP130 interaction drives glioblastoma stem cell plasticity and chemoresistance through STAT3 activity
por: Filppu, Pauliina, et al.
Publicado: (2021)

Circumventing the Greatwall
por: Short, Ben
Publicado: (2014)

Development of actionable targets of multi-kinase inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cells
por: Denisova, Oxana V., et al.
Publicado: (2022)

A novel Poly(ε-caprolactone)-Pluronic-Poly(ε-caprolactone) grafted Polyethyleneimine(PCFC-g-PEI), Part 1, synthesis, cytotoxicity, and in vitro transfection study
por: Shi, Shuai, et al.
Publicado: (2009)

Prostate‐specific membrane antigen expression in the vasculature of primary lung carcinomas associates with faster metastatic dissemination to the brain
por: Tanjore Ramanathan, Jayendrakishore, et al.
Publicado: (2020)

Two Major Archaeal Pseudomurein Endoisopeptidases: PeiW and PeiP
por: Visweswaran, Ganesh Ram R., et al.
Publicado: (2010)

Recent Advances in the Use of Mesoporous Silica Nanoparticles for the Diagnosis of Bacterial Infections
por: Şen Karaman, Didem, et al.
Publicado: (2021)

Cephem‐Pyrazinoic Acid Conjugates: Circumventing Resistance in Mycobacterium tuberculosis
por: Cole, Malcolm S., et al.
Publicado: (2022)

Biochemical Characterisation of Phage Pseudomurein Endoisopeptidases PeiW and PeiP Using Synthetic Peptides
por: Schofield, Linley R., et al.
Publicado: (2015)

Inhibition of adaptive therapy tolerance in cancer: is triplet mitochondrial targeting the key?
por: Westermarck, Jukka
Publicado: (2023)

Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization
por: Le Joncour, Vadim, et al.
Publicado: (2019)

I. M. Pei : a profile in american architecture
por: Wiseman, Carter
Publicado: (1990)

Intrinsic and Extrinsic Properties Affecting Innate Immune Responses to Nanoparticles: The Case of Cerium Oxide
por: Casals, Eudald, et al.
Publicado: (2017)

2D Fluorinated Graphene Oxide (FGO)-Polyethyleneimine (PEI) Based 3D Porous Nanoplatform for Effective Removal of Forever Toxic Chemicals, Pharmaceutical Toxins, and Waterborne Pathogens from Environmental Water Samples
por: Pramanik, Avijit, et al.
Publicado: (2023)

Corrigendum: Intrinsic and Extrinsic Properties Affecting Innate Immune Responses to Nanoparticles: The Case of Cerium Oxide
por: Casals, Eudald, et al.
Publicado: (2017)

Core-Shell Structures of Upconversion Nanocrystals Coated with Silica for Near Infrared Light Enabled Optical Imaging of Cancer Cells
por: Lingeshwar Reddy, Kumbam, et al.
Publicado: (2018)

Conversations with I.M. Pei : light is the key /
por: Boehm, Gero von, 1954-
Publicado: (2000)

Octreotide Conjugates for Tumor Targeting and Imaging
por: Figueras, Eduard, et al.
Publicado: (2019)

Peptide-Based Strategies for Targeted Tumor Treatment and Imaging
por: Ayo, Abiodun, et al.
Publicado: (2021)

CRISPR Screens in Synthetic Lethality and Combinatorial Therapies for Cancer
por: Castells-Roca, Laia, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_g0ahljr2cgp6762l731eu0ot7d