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MiR-126 Is an Independent Predictor of Long-Term All-Cause Mortality in Patients with Type 2 Diabetes Mellitus

MicroRNAs are endogenous non-coding RNAs that are involved in numerous biological processes through regulation of gene expression. The aim of our study was to determine the ability of several miRNAs to predict mortality and response to antiplatelet treatment among T2DM patients. Two hundred fifty-tw...

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Autores principales: Pordzik, Justyna, Eyileten-Postuła, Ceren, Jakubik, Daniel, Czajka, Pamela, Nowak, Anna, De Rosa, Salvatore, Gąsecka, Aleksandra, Cieślicka-Kapłon, Agnieszka, Sulikowski, Piotr, Filipiak, Krzysztof J., Mirowska-Guzel, Dagmara, Siller-Matula, Jolanta M., Postuła, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198825/
https://www.ncbi.nlm.nih.gov/pubmed/34071189
http://dx.doi.org/10.3390/jcm10112371
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author Pordzik, Justyna
Eyileten-Postuła, Ceren
Jakubik, Daniel
Czajka, Pamela
Nowak, Anna
De Rosa, Salvatore
Gąsecka, Aleksandra
Cieślicka-Kapłon, Agnieszka
Sulikowski, Piotr
Filipiak, Krzysztof J.
Mirowska-Guzel, Dagmara
Siller-Matula, Jolanta M.
Postuła, Marek
author_facet Pordzik, Justyna
Eyileten-Postuła, Ceren
Jakubik, Daniel
Czajka, Pamela
Nowak, Anna
De Rosa, Salvatore
Gąsecka, Aleksandra
Cieślicka-Kapłon, Agnieszka
Sulikowski, Piotr
Filipiak, Krzysztof J.
Mirowska-Guzel, Dagmara
Siller-Matula, Jolanta M.
Postuła, Marek
author_sort Pordzik, Justyna
collection PubMed
description MicroRNAs are endogenous non-coding RNAs that are involved in numerous biological processes through regulation of gene expression. The aim of our study was to determine the ability of several miRNAs to predict mortality and response to antiplatelet treatment among T2DM patients. Two hundred fifty-two patients with diabetes were enrolled in the study. Among the patients included, 26 (10.3%) patients died within a median observation time of 5.9 years. The patients were receiving either acetylsalicylic acid (ASA) 75 mg (65%), ASA 150 mg (15%) or clopidogrel (19%). Plasma miR-126, miR-223, miR-125a-3p and Let-7e expressions were assessed by quantitative real time PCR and compared between the patients who survived and those who died. Adjusted Cox-regression analysis was used for prediction of mortality. Differential miRNA expression due to different antiplatelet treatment was analyzed. After including all miRNAs into one multivariate Cox regression model, only miR-126 was predictive of future occurrence of long-term all-cause death (HR = 5.82, 95% CI: 1.3–24.9; p = 0.024). Furthermore, miR-126, Let-7e and miR-223 expressions in the clopidogrel group were significantly higher than in the ASA group (p = 0.014; p = 0.013; p = 0.028, respectively). To conclude, miR-126 expression is a strong and independent predictor of long-term all-cause mortality among patients with T2DM. Moreover, miR-223, miR-126 and Let-7e present significant interactions with antiplatelet treatment regimens and clinical outcomes.
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spelling pubmed-81988252021-06-14 MiR-126 Is an Independent Predictor of Long-Term All-Cause Mortality in Patients with Type 2 Diabetes Mellitus Pordzik, Justyna Eyileten-Postuła, Ceren Jakubik, Daniel Czajka, Pamela Nowak, Anna De Rosa, Salvatore Gąsecka, Aleksandra Cieślicka-Kapłon, Agnieszka Sulikowski, Piotr Filipiak, Krzysztof J. Mirowska-Guzel, Dagmara Siller-Matula, Jolanta M. Postuła, Marek J Clin Med Article MicroRNAs are endogenous non-coding RNAs that are involved in numerous biological processes through regulation of gene expression. The aim of our study was to determine the ability of several miRNAs to predict mortality and response to antiplatelet treatment among T2DM patients. Two hundred fifty-two patients with diabetes were enrolled in the study. Among the patients included, 26 (10.3%) patients died within a median observation time of 5.9 years. The patients were receiving either acetylsalicylic acid (ASA) 75 mg (65%), ASA 150 mg (15%) or clopidogrel (19%). Plasma miR-126, miR-223, miR-125a-3p and Let-7e expressions were assessed by quantitative real time PCR and compared between the patients who survived and those who died. Adjusted Cox-regression analysis was used for prediction of mortality. Differential miRNA expression due to different antiplatelet treatment was analyzed. After including all miRNAs into one multivariate Cox regression model, only miR-126 was predictive of future occurrence of long-term all-cause death (HR = 5.82, 95% CI: 1.3–24.9; p = 0.024). Furthermore, miR-126, Let-7e and miR-223 expressions in the clopidogrel group were significantly higher than in the ASA group (p = 0.014; p = 0.013; p = 0.028, respectively). To conclude, miR-126 expression is a strong and independent predictor of long-term all-cause mortality among patients with T2DM. Moreover, miR-223, miR-126 and Let-7e present significant interactions with antiplatelet treatment regimens and clinical outcomes. MDPI 2021-05-28 /pmc/articles/PMC8198825/ /pubmed/34071189 http://dx.doi.org/10.3390/jcm10112371 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pordzik, Justyna
Eyileten-Postuła, Ceren
Jakubik, Daniel
Czajka, Pamela
Nowak, Anna
De Rosa, Salvatore
Gąsecka, Aleksandra
Cieślicka-Kapłon, Agnieszka
Sulikowski, Piotr
Filipiak, Krzysztof J.
Mirowska-Guzel, Dagmara
Siller-Matula, Jolanta M.
Postuła, Marek
MiR-126 Is an Independent Predictor of Long-Term All-Cause Mortality in Patients with Type 2 Diabetes Mellitus
title MiR-126 Is an Independent Predictor of Long-Term All-Cause Mortality in Patients with Type 2 Diabetes Mellitus
title_full MiR-126 Is an Independent Predictor of Long-Term All-Cause Mortality in Patients with Type 2 Diabetes Mellitus
title_fullStr MiR-126 Is an Independent Predictor of Long-Term All-Cause Mortality in Patients with Type 2 Diabetes Mellitus
title_full_unstemmed MiR-126 Is an Independent Predictor of Long-Term All-Cause Mortality in Patients with Type 2 Diabetes Mellitus
title_short MiR-126 Is an Independent Predictor of Long-Term All-Cause Mortality in Patients with Type 2 Diabetes Mellitus
title_sort mir-126 is an independent predictor of long-term all-cause mortality in patients with type 2 diabetes mellitus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198825/
https://www.ncbi.nlm.nih.gov/pubmed/34071189
http://dx.doi.org/10.3390/jcm10112371
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