Cargando…

Investigating the Antifungal Mechanism of Action of Polygodial by Phenotypic Screening in Saccharomyces cerevisiae

Polygodial is a “hot” peppery-tasting sesquiterpenoid that was first described for its anti-feedant activity against African armyworms. Using the haploid deletion mutant library of Saccharomyces cerevisiae, a genome-wide mutant screen was performed to shed more light on polygodial’s antifungal mecha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kipanga, Purity N., Demuyser, Liesbeth, Vrijdag, Johannes, Eskes, Elja, D’hooge, Petra, Matasyoh, Josphat, Callewaert, Geert, Winderickx, Joris, Van Dijck, Patrick, Luyten, Walter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198865/ https://www.ncbi.nlm.nih.gov/pubmed/34071169 http://dx.doi.org/10.3390/ijms22115756

Ejemplares similares

Decreased Vacuolar Ca(2+) Storage and Disrupted Vesicle Trafficking Underlie Alpha-Synuclein-Induced Ca(2+) Dysregulation in S. cerevisiae
por: Callewaert, Geert, et al.
Publicado: (2020)

Mitochondrial Cochaperone Mge1 Is Involved in Regulating Susceptibility to Fluconazole in Saccharomyces cerevisiae and Candida Species
por: Demuyser, Liesbeth, et al.
Publicado: (2017)

pH homeostasis in yeast; the phosphate perspective
por: Eskes, Elja, et al.
Publicado: (2017)

pH homeostasis links the nutrient sensing PKA/TORC1/Sch9 ménage-à-trois to stress tolerance and longevity
por: Deprez, Marie-Anne, et al.
Publicado: (2018)

Antifungal Effect of Polygodial on Botrytis cinerea, a Fungal Pathogen Affecting Table Grapes
por: Carrasco, Héctor, et al.
Publicado: (2017)

Molecular Elucidation of Riboflavin Production and Regulation in Candida albicans, toward a Novel Antifungal Drug Target
por: Demuyser, Liesbeth, et al.
Publicado: (2020)

Rim15 and the crossroads of nutrient signalling pathways in Saccharomyces cerevisiae
por: Swinnen, Erwin, et al.
Publicado: (2006)

Polygodial and Ophiobolin A Analogues for Covalent Crosslinking of Anticancer Targets
por: Maslivetc, Vladimir, et al.
Publicado: (2021)

Systematic Prediction of Antifungal Drug Synergy by Chemogenomic Screening in Saccharomyces cerevisiae
por: Gaikani, Hamid, et al.
Publicado: (2021)

The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae
por: Swinnen, Erwin, et al.
Publicado: (2014)

Fluorescent toys ‘n’ tools lighting the way in fungal research
por: Van Genechten, Wouter, et al.
Publicado: (2021)

A genome-wide imaging-based screening to identify genes involved in synphilin-1 inclusion formation in Saccharomyces cerevisiae
por: Zhao, Lei, et al.
Publicado: (2016)

Identification and Characterization of Antifungal Compounds Using a Saccharomyces cerevisiae Reporter Bioassay
por: Tebbets, Brad, et al.
Publicado: (2012)

The antifungal effect of cellobiose lipid on the cells of Saccharomyces cerevisiae depends on carbon source
por: Trilisenko, Ludmila V, et al.
Publicado: (2012)

Saccharomyces cerevisiae biofilm tolerance towards systemic antifungals depends on growth phase
por: Bojsen, Rasmus, et al.
Publicado: (2014)

The splicing mutant of the human tumor suppressor protein DFNA5 induces programmed cell death when expressed in the yeast Saccharomyces cerevisiae
por: Van Rossom, Sofie, et al.
Publicado: (2012)

Presenting a codon-optimized palette of fluorescent proteins for use in Candida albicans
por: Van Genechten, Wouter, et al.
Publicado: (2020)

Drug-dependent growth curve reshaping reveals mechanisms of antifungal resistance in Saccharomyces cerevisiae
por: Guinn, Lesia, et al.
Publicado: (2022)

Endophytes as Producers of Peptides: An Overview About the Recently Discovered Peptides from Endophytic Microbes
por: Abdalla, Muna Ali, et al.
Publicado: (2014)

In Vitro Assessment of Azole and Amphotericin B Susceptibilities of Malassezia spp. Isolated from Healthy and Lesioned Skin
por: Chebil, Wissal, et al.
Publicado: (2022)

Synergistic and antagonistic effects of immunomodulatory drugs on the action of antifungals against Candida glabrata and Saccharomyces cerevisiae
por: Tome, Miha, et al.
Publicado: (2018)

Ctt1 catalase activity potentiates antifungal azoles in the emerging opportunistic pathogen Saccharomyces cerevisiae
por: Martins, Dorival, et al.
Publicado: (2019)

The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability
por: Wilms, Tobias, et al.
Publicado: (2017)

Author Correction: Drug-dependent growth curve reshaping reveals mechanisms of antifungal resistance in Saccharomyces cerevisiae
por: Guinn, Lesia, et al.
Publicado: (2022)

Novel findings about the mode of action of the antifungal protein PeAfpA against Saccharomyces cerevisiae
por: Giner-Llorca, Moisés, et al.
Publicado: (2023)

High-resolution melting analysis reveals low Plasmodium parasitaemia infections among microscopically negative febrile patients in western Kenya
por: Kipanga, Purity N, et al.
Publicado: (2014)

Polygodial, a Sesquiterpene Dialdehyde, Activates Apoptotic Signaling in Castration-Resistant Prostate Cancer Cell Lines by Inducing Oxidative Stress
por: Venkatesan, Reshmii, et al.
Publicado: (2022)

The nutrient-responsive CDK Pho85 primes the Sch9 kinase for its activation by TORC1
por: Deprez, Marie-Anne, et al.
Publicado: (2023)

The Role of Fatty Acid Metabolites in Vaginal Health and Disease: Application to Candidiasis
por: Baldewijns, Silke, et al.
Publicado: (2021)

Chemical Composition and Flavor Characteristics of Cider Fermented with Saccharomyces cerevisiae and Non-Saccharomyces cerevisiae
por: Wu, Yuzheng, et al.
Publicado: (2023)

Larvicidal activity of metabolites from the endophytic Podospora sp. against the malaria vector Anopheles gambiae
por: Matasyoh, Josphat C., et al.
Publicado: (2010)

Photochromic Fluorophores Enable Imaging of Lowly Expressed Proteins in the Autofluorescent Fungus Candida albicans
por: Van Genechten, Wouter, et al.
Publicado: (2021)

The flavoproteome of the yeast Saccharomyces cerevisiae()
por: Gudipati, Venugopal, et al.
Publicado: (2014)

Mobilomics in Saccharomyces cerevisiae strains
por: Menconi, Giulia, et al.
Publicado: (2013)

Glucose repression in Saccharomyces cerevisiae
por: Kayikci, Ömur, et al.
Publicado: (2015)

Chromosome Duplication in Saccharomyces cerevisiae
por: Bell, Stephen P., et al.
Publicado: (2016)

The subcellular organisation of Saccharomyces cerevisiae
por: Nightingale, Daniel JH, et al.
Publicado: (2019)

Expansion Microscopy on Saccharomyces cerevisiae
por: Korovesi, Artemis G., et al.
Publicado: (2022)

Novel polygodial analogs P3 and P27: Efficacious therapeutic agents disrupting mitochondrial function in oral squamous cell carcinoma
por: De La Chapa, Jorge, et al.
Publicado: (2018)

Novel polygodial analogs P3 and P27: Efficacious therapeutic agents disrupting mitochondrial function in oral squamous cell carcinoma
por: De La Chapa, Jorge, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_95lctkgiju3lollmgocmqe9eaf