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Role of Receptor Protein Tyrosine Phosphatases (RPTPs) in Insulin Signaling and Secretion

Changes in lifestyle in developed countries have triggered the prevalence of obesity and type 2 diabetes mellitus (T2DM) in the latest years. Consequently, these metabolic diseases associated to insulin resistance, and the morbidity associated with them, accounts for enormous costs for the health sy...

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Autores principales: Sevillano, Julio, Sánchez-Alonso, María Gracia, Pizarro-Delgado, Javier, Ramos-Álvarez, María del Pilar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198922/
https://www.ncbi.nlm.nih.gov/pubmed/34071721
http://dx.doi.org/10.3390/ijms22115812
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author Sevillano, Julio
Sánchez-Alonso, María Gracia
Pizarro-Delgado, Javier
Ramos-Álvarez, María del Pilar
author_facet Sevillano, Julio
Sánchez-Alonso, María Gracia
Pizarro-Delgado, Javier
Ramos-Álvarez, María del Pilar
author_sort Sevillano, Julio
collection PubMed
description Changes in lifestyle in developed countries have triggered the prevalence of obesity and type 2 diabetes mellitus (T2DM) in the latest years. Consequently, these metabolic diseases associated to insulin resistance, and the morbidity associated with them, accounts for enormous costs for the health systems. The best way to face this problem is to identify potential therapeutic targets and/or early biomarkers to help in the treatment and in the early detection. In the insulin receptor signaling cascade, the activities of protein tyrosine kinases and phosphatases are coordinated, thus, protein tyrosine kinases amplify the insulin signaling response, whereas phosphatases are required for the regulation of the rate and duration of that response. The focus of this review is to summarize the impact of transmembrane receptor protein tyrosine phosphatase (RPTPs) in the insulin signaling cascade and secretion, and their implication in metabolic diseases such as obesity and T2DM.
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spelling pubmed-81989222021-06-14 Role of Receptor Protein Tyrosine Phosphatases (RPTPs) in Insulin Signaling and Secretion Sevillano, Julio Sánchez-Alonso, María Gracia Pizarro-Delgado, Javier Ramos-Álvarez, María del Pilar Int J Mol Sci Review Changes in lifestyle in developed countries have triggered the prevalence of obesity and type 2 diabetes mellitus (T2DM) in the latest years. Consequently, these metabolic diseases associated to insulin resistance, and the morbidity associated with them, accounts for enormous costs for the health systems. The best way to face this problem is to identify potential therapeutic targets and/or early biomarkers to help in the treatment and in the early detection. In the insulin receptor signaling cascade, the activities of protein tyrosine kinases and phosphatases are coordinated, thus, protein tyrosine kinases amplify the insulin signaling response, whereas phosphatases are required for the regulation of the rate and duration of that response. The focus of this review is to summarize the impact of transmembrane receptor protein tyrosine phosphatase (RPTPs) in the insulin signaling cascade and secretion, and their implication in metabolic diseases such as obesity and T2DM. MDPI 2021-05-28 /pmc/articles/PMC8198922/ /pubmed/34071721 http://dx.doi.org/10.3390/ijms22115812 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sevillano, Julio
Sánchez-Alonso, María Gracia
Pizarro-Delgado, Javier
Ramos-Álvarez, María del Pilar
Role of Receptor Protein Tyrosine Phosphatases (RPTPs) in Insulin Signaling and Secretion
title Role of Receptor Protein Tyrosine Phosphatases (RPTPs) in Insulin Signaling and Secretion
title_full Role of Receptor Protein Tyrosine Phosphatases (RPTPs) in Insulin Signaling and Secretion
title_fullStr Role of Receptor Protein Tyrosine Phosphatases (RPTPs) in Insulin Signaling and Secretion
title_full_unstemmed Role of Receptor Protein Tyrosine Phosphatases (RPTPs) in Insulin Signaling and Secretion
title_short Role of Receptor Protein Tyrosine Phosphatases (RPTPs) in Insulin Signaling and Secretion
title_sort role of receptor protein tyrosine phosphatases (rptps) in insulin signaling and secretion
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198922/
https://www.ncbi.nlm.nih.gov/pubmed/34071721
http://dx.doi.org/10.3390/ijms22115812
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