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Exploration of Potential Genetic Biomarkers for Heart Failure: A Systematic Review

Patients with heart failure (HF) often present with signs and symptoms that are often nonspecific and with a wide differential diagnosis, making diagnosis and prognosis of HF by clinical presentation alone challenging. Our knowledge on genetic diversity is rapidly evolving with high-throughput DNA s...

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Autores principales: Chair, Sek-Ying, Chan, Judy-Yuet-Wa, Waye, Mary-Miu-Yee, Liu, Ting, Law, Bernard-Man-Hin, Chien, Wai-Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198957/
https://www.ncbi.nlm.nih.gov/pubmed/34072866
http://dx.doi.org/10.3390/ijerph18115904
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author Chair, Sek-Ying
Chan, Judy-Yuet-Wa
Waye, Mary-Miu-Yee
Liu, Ting
Law, Bernard-Man-Hin
Chien, Wai-Tong
author_facet Chair, Sek-Ying
Chan, Judy-Yuet-Wa
Waye, Mary-Miu-Yee
Liu, Ting
Law, Bernard-Man-Hin
Chien, Wai-Tong
author_sort Chair, Sek-Ying
collection PubMed
description Patients with heart failure (HF) often present with signs and symptoms that are often nonspecific and with a wide differential diagnosis, making diagnosis and prognosis of HF by clinical presentation alone challenging. Our knowledge on genetic diversity is rapidly evolving with high-throughput DNA sequencing technology, which makes a great potential for genetic biomarker development. The present review attempts to provide a comprehensive review on the modification of major genetic components in HF patients and to explore the potential application of these components as clinical biomarkers in the diagnosis and in monitoring the progress of HF. The literature search was conducted using six databases, resulting in the inclusion of eighteen studies in the review. The findings of these studies were summarized narratively. An appraisal of the reporting quality of the included studies was conducted using a twelve-item checklist adapted from the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist. The findings showed that changes in genetic components in patients with HF compared to healthy controls could be noninvasive diagnostic or prognostic tools for HF with higher specificity and sensitivity in comparison with the traditional biomarkers. This review provided evidence for the potential of developing genetic biomarkers of HF.
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spelling pubmed-81989572021-06-14 Exploration of Potential Genetic Biomarkers for Heart Failure: A Systematic Review Chair, Sek-Ying Chan, Judy-Yuet-Wa Waye, Mary-Miu-Yee Liu, Ting Law, Bernard-Man-Hin Chien, Wai-Tong Int J Environ Res Public Health Review Patients with heart failure (HF) often present with signs and symptoms that are often nonspecific and with a wide differential diagnosis, making diagnosis and prognosis of HF by clinical presentation alone challenging. Our knowledge on genetic diversity is rapidly evolving with high-throughput DNA sequencing technology, which makes a great potential for genetic biomarker development. The present review attempts to provide a comprehensive review on the modification of major genetic components in HF patients and to explore the potential application of these components as clinical biomarkers in the diagnosis and in monitoring the progress of HF. The literature search was conducted using six databases, resulting in the inclusion of eighteen studies in the review. The findings of these studies were summarized narratively. An appraisal of the reporting quality of the included studies was conducted using a twelve-item checklist adapted from the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist. The findings showed that changes in genetic components in patients with HF compared to healthy controls could be noninvasive diagnostic or prognostic tools for HF with higher specificity and sensitivity in comparison with the traditional biomarkers. This review provided evidence for the potential of developing genetic biomarkers of HF. MDPI 2021-05-31 /pmc/articles/PMC8198957/ /pubmed/34072866 http://dx.doi.org/10.3390/ijerph18115904 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Chair, Sek-Ying
Chan, Judy-Yuet-Wa
Waye, Mary-Miu-Yee
Liu, Ting
Law, Bernard-Man-Hin
Chien, Wai-Tong
Exploration of Potential Genetic Biomarkers for Heart Failure: A Systematic Review
title Exploration of Potential Genetic Biomarkers for Heart Failure: A Systematic Review
title_full Exploration of Potential Genetic Biomarkers for Heart Failure: A Systematic Review
title_fullStr Exploration of Potential Genetic Biomarkers for Heart Failure: A Systematic Review
title_full_unstemmed Exploration of Potential Genetic Biomarkers for Heart Failure: A Systematic Review
title_short Exploration of Potential Genetic Biomarkers for Heart Failure: A Systematic Review
title_sort exploration of potential genetic biomarkers for heart failure: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198957/
https://www.ncbi.nlm.nih.gov/pubmed/34072866
http://dx.doi.org/10.3390/ijerph18115904
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