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Evaluation of Effects of Diabetes Mellitus, Hypercholesterolemia and Hypertension on Bell’s Palsy
The aim of this study is to evaluate the effects of diabetes mellitus, hypertension and hypercholesterolemia on the clinical presentation and outcome of Bell’s palsy. The study (comorbidity) group consisted of 50 patients with Bell’s palsy associated with diabetes, hypertension, or hypercholesterole...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198958/ https://www.ncbi.nlm.nih.gov/pubmed/34072018 http://dx.doi.org/10.3390/jcm10112357 |
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author | Psillas, George Dimas, Grigorios G. Sarafidou, Anastasia Didangelos, Triantafyllos Perifanis, Vasilios Kaiafa, Georgia Mirkopoulou, Daphne Tegos, Thomas Savopoulos, Christos Constantinidis, Jiannis |
author_facet | Psillas, George Dimas, Grigorios G. Sarafidou, Anastasia Didangelos, Triantafyllos Perifanis, Vasilios Kaiafa, Georgia Mirkopoulou, Daphne Tegos, Thomas Savopoulos, Christos Constantinidis, Jiannis |
author_sort | Psillas, George |
collection | PubMed |
description | The aim of this study is to evaluate the effects of diabetes mellitus, hypertension and hypercholesterolemia on the clinical presentation and outcome of Bell’s palsy. The study (comorbidity) group consisted of 50 patients with Bell’s palsy associated with diabetes, hypertension, or hypercholesterolemia; the control group included 46 patients with Bell’s palsy, but without comorbid diseases. The House–Brackmann grading system (I to VI) was used in order to assess the initial and final facial functions. Both groups of patients were treated with steroids and the antiviral agent acyclovir. The mean severity of initial facial paralysis was more significant in diabetes, hypercholesterolemia, and hypertension, in comparison to the control group. Patients suffering from Bell’s palsy and concomitant comorbidities have a poorer prognosis (HB III-VI) compared to patients without comorbidities. Increased glycosylated hemoglobin A1c levels (>6.7%) were significantly correlated with unsatisfactory facial recovery. The pathogenetic mechanisms by which diabetes, hypercholesterolemia, and hypertension affect the vasa nervosum of facial nerve have been described. |
format | Online Article Text |
id | pubmed-8198958 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81989582021-06-14 Evaluation of Effects of Diabetes Mellitus, Hypercholesterolemia and Hypertension on Bell’s Palsy Psillas, George Dimas, Grigorios G. Sarafidou, Anastasia Didangelos, Triantafyllos Perifanis, Vasilios Kaiafa, Georgia Mirkopoulou, Daphne Tegos, Thomas Savopoulos, Christos Constantinidis, Jiannis J Clin Med Article The aim of this study is to evaluate the effects of diabetes mellitus, hypertension and hypercholesterolemia on the clinical presentation and outcome of Bell’s palsy. The study (comorbidity) group consisted of 50 patients with Bell’s palsy associated with diabetes, hypertension, or hypercholesterolemia; the control group included 46 patients with Bell’s palsy, but without comorbid diseases. The House–Brackmann grading system (I to VI) was used in order to assess the initial and final facial functions. Both groups of patients were treated with steroids and the antiviral agent acyclovir. The mean severity of initial facial paralysis was more significant in diabetes, hypercholesterolemia, and hypertension, in comparison to the control group. Patients suffering from Bell’s palsy and concomitant comorbidities have a poorer prognosis (HB III-VI) compared to patients without comorbidities. Increased glycosylated hemoglobin A1c levels (>6.7%) were significantly correlated with unsatisfactory facial recovery. The pathogenetic mechanisms by which diabetes, hypercholesterolemia, and hypertension affect the vasa nervosum of facial nerve have been described. MDPI 2021-05-27 /pmc/articles/PMC8198958/ /pubmed/34072018 http://dx.doi.org/10.3390/jcm10112357 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Psillas, George Dimas, Grigorios G. Sarafidou, Anastasia Didangelos, Triantafyllos Perifanis, Vasilios Kaiafa, Georgia Mirkopoulou, Daphne Tegos, Thomas Savopoulos, Christos Constantinidis, Jiannis Evaluation of Effects of Diabetes Mellitus, Hypercholesterolemia and Hypertension on Bell’s Palsy |
title | Evaluation of Effects of Diabetes Mellitus, Hypercholesterolemia and Hypertension on Bell’s Palsy |
title_full | Evaluation of Effects of Diabetes Mellitus, Hypercholesterolemia and Hypertension on Bell’s Palsy |
title_fullStr | Evaluation of Effects of Diabetes Mellitus, Hypercholesterolemia and Hypertension on Bell’s Palsy |
title_full_unstemmed | Evaluation of Effects of Diabetes Mellitus, Hypercholesterolemia and Hypertension on Bell’s Palsy |
title_short | Evaluation of Effects of Diabetes Mellitus, Hypercholesterolemia and Hypertension on Bell’s Palsy |
title_sort | evaluation of effects of diabetes mellitus, hypercholesterolemia and hypertension on bell’s palsy |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198958/ https://www.ncbi.nlm.nih.gov/pubmed/34072018 http://dx.doi.org/10.3390/jcm10112357 |
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