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Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study

(1) Background: We investigated the role of [11C]-methionine PET in a cohort of newly diagnosed glioblastoma multiforme (GBM) patients to evaluate whether it could modify the extent of surgical resection and improve radiation therapy volume delineation. (2) Methods: Newly diagnosed GBM patients, age...

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Autores principales: Pessina, Federico, Navarria, Pierina, Clerici, Elena, Bellu, Luisa, Franzini, Andrea, Milani, Davide, Simonelli, Matteo, Persico, Pasquale, Politi, Letterio S., Casarotti, Alessandra, Fernandes, Bethania, Olei, Simone, Sollini, Martina, Chiti, Arturo, Scorsetti, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198980/
https://www.ncbi.nlm.nih.gov/pubmed/34070698
http://dx.doi.org/10.3390/jcm10112313
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author Pessina, Federico
Navarria, Pierina
Clerici, Elena
Bellu, Luisa
Franzini, Andrea
Milani, Davide
Simonelli, Matteo
Persico, Pasquale
Politi, Letterio S.
Casarotti, Alessandra
Fernandes, Bethania
Olei, Simone
Sollini, Martina
Chiti, Arturo
Scorsetti, Marta
author_facet Pessina, Federico
Navarria, Pierina
Clerici, Elena
Bellu, Luisa
Franzini, Andrea
Milani, Davide
Simonelli, Matteo
Persico, Pasquale
Politi, Letterio S.
Casarotti, Alessandra
Fernandes, Bethania
Olei, Simone
Sollini, Martina
Chiti, Arturo
Scorsetti, Marta
author_sort Pessina, Federico
collection PubMed
description (1) Background: We investigated the role of [11C]-methionine PET in a cohort of newly diagnosed glioblastoma multiforme (GBM) patients to evaluate whether it could modify the extent of surgical resection and improve radiation therapy volume delineation. (2) Methods: Newly diagnosed GBM patients, ages 18–70, with a Karnofsky performance scale (KPS) ≥ 70 with available MRI and [11C]-methionine PET were included. Patients were treated with different amounts of surgical resection followed by radio-chemotherapy. The role of [11C]-methionine PET in surgical and RT planning was analyzed. A threshold of SUVmax was searched. (3) Results: From August 2013 to April 2016, 93 patients were treated and included in this analysis. Residual tumor volume was detected in 63 cases on MRI and in 78 on [11C]-methionine PET, including 15 receiving gross total resection. The location of uptake was mainly observed in FLAIR abnormalities. [11C]-methionine uptake changed RT volume in 11% of patients. The presence of [11C]-methionine uptake in patients receiving GTR proved to influence survival (p = 0.029). The threshold of the SUVmax conditioning outcome was five. (4) Conclusions: [11C]-methionine PET allowed to detect areas at higher risk of recurrence located in FLAIR abnormalities in patients affected by GBM. A challenging issue is represented by integrating morphological and functional imaging to better define the extent of surgical resection to perform.
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spelling pubmed-81989802021-06-14 Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study Pessina, Federico Navarria, Pierina Clerici, Elena Bellu, Luisa Franzini, Andrea Milani, Davide Simonelli, Matteo Persico, Pasquale Politi, Letterio S. Casarotti, Alessandra Fernandes, Bethania Olei, Simone Sollini, Martina Chiti, Arturo Scorsetti, Marta J Clin Med Article (1) Background: We investigated the role of [11C]-methionine PET in a cohort of newly diagnosed glioblastoma multiforme (GBM) patients to evaluate whether it could modify the extent of surgical resection and improve radiation therapy volume delineation. (2) Methods: Newly diagnosed GBM patients, ages 18–70, with a Karnofsky performance scale (KPS) ≥ 70 with available MRI and [11C]-methionine PET were included. Patients were treated with different amounts of surgical resection followed by radio-chemotherapy. The role of [11C]-methionine PET in surgical and RT planning was analyzed. A threshold of SUVmax was searched. (3) Results: From August 2013 to April 2016, 93 patients were treated and included in this analysis. Residual tumor volume was detected in 63 cases on MRI and in 78 on [11C]-methionine PET, including 15 receiving gross total resection. The location of uptake was mainly observed in FLAIR abnormalities. [11C]-methionine uptake changed RT volume in 11% of patients. The presence of [11C]-methionine uptake in patients receiving GTR proved to influence survival (p = 0.029). The threshold of the SUVmax conditioning outcome was five. (4) Conclusions: [11C]-methionine PET allowed to detect areas at higher risk of recurrence located in FLAIR abnormalities in patients affected by GBM. A challenging issue is represented by integrating morphological and functional imaging to better define the extent of surgical resection to perform. MDPI 2021-05-25 /pmc/articles/PMC8198980/ /pubmed/34070698 http://dx.doi.org/10.3390/jcm10112313 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pessina, Federico
Navarria, Pierina
Clerici, Elena
Bellu, Luisa
Franzini, Andrea
Milani, Davide
Simonelli, Matteo
Persico, Pasquale
Politi, Letterio S.
Casarotti, Alessandra
Fernandes, Bethania
Olei, Simone
Sollini, Martina
Chiti, Arturo
Scorsetti, Marta
Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study
title Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study
title_full Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study
title_fullStr Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study
title_full_unstemmed Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study
title_short Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study
title_sort role of 11c methionine positron emission tomography (11cmetpet) for surgery and radiation therapy planning in newly diagnosed glioblastoma patients enrolled into a phase ii clinical study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198980/
https://www.ncbi.nlm.nih.gov/pubmed/34070698
http://dx.doi.org/10.3390/jcm10112313
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